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9873 documents

Investigating the Impact of Social Isolation on Bone Metabolism

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Rebecca Mountain · MAINEHEALTH · 2024 · $127,427 — PROJECT SUMMARY Social isolation is a potent form of psychosocial stress, and a growing public health concern. Older adults, particularly those individuals isolated during the COVID-19 pandemic, are particularly vulnerable. One in four individuals over the age of 65 are estimated to be affected by s…

BLRD Research Career Scientist Award Application

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Robert Raffai · VETERANS AFFAIRS MED CTR SAN FRANCISCO · 2024 — The overall goal of this Research Career Scientist award is to foster the nominee’s ongoing research program that is focused on the study of extracellular vesicles (EVs) and their extracellular RNA (exRNA) cargo as biomarkers and effectors of human health and disease including among Veterans. Throug…

Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Sathish Venkatachalem · NORTH DAKOTA STATE UNIVERSITY · 2024 · $1,860,485 — PROJECT SUMMARY Although the survival for other cancers improved during the last ten years, the outlook for pancreatic ductal adenocarcinoma (PDAC) remains grim. The average overall 5-year survival rate for PDAC is 10.8%. The mission of the Center for Diagnostic and Therapeutic Strategies in Pancrea…

PREDICT (Precision Medicine, Education, Data Informatics and Community Translation) Institute

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Kathleen B. Kennedy · XAVIER UNIVERSITY OF LOUISIANA · 2024 · $2,000,000 — ABSTRACT Xavier University of Louisiana seeks support from the NIH National Institute on Minority Health and Health Disparities to complement the research infrastructure in the College of Pharmacy through a new initiative. The proposed initiative will establish the Precision Medicine, Education, Dat…

Deep South Center to Reduce Disparities in Chronic Diseases

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

MONICA L. BASKIN · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2024 · $4,239,524 — ABSTRACT The “Deep South,” including Alabama, Mississippi, and Louisiana, has the highest rates of obesity, diabetes and hypertension in the nation. As a result, life expectancy in the Deep South is substantially lower than other regions. The mission of the Deep South Center to Reduce Disparities in…

Advancing Transplantation Outcomes in Children

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

David M. Briscoe · BOSTON CHILDREN'S HOSPITAL · 2024 · $1,002,068 — Project Summary/Abstract Renal transplantation is widely recognized as the treatment of choice for children with end stage renal disease (ESRD). The life expectancy benefit is significant and a functioning renal transplant enables children to grow well, develop almost normally and improve their scho…

Scaling-Up Integrative Pain Management in Federally Qualified Health Centers

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Isabel Roth · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $117,118 — PROJECT SUMMARY Background: Chronic pain impacts a fifth of American adults. Integrative pain management (IPM) interventions including mindfulness-based stress reduction, yoga, and other methods have demonstrated improvements in pain and function, and are now included in clinical guidelines for chro…

Viral IncRNAs Regulate Host Genomic Transcriptional Programs Associated with Sporadic Alzheimer's Disease

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

MICHAEL G ROSENFELD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $399,310 — ABSTRACT Alzheimer’s disease (AD) presents a formidable therapeutic challenge, as current interventions have failed to slow disease progression. The majority of AD genetic risk variants identified by GWAS reside in non- coding regions of the genome, suggesting that alterations in gene expression con…

Resilience and brain health of older adults during the COVID-19 pandemic

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Breno Satler Diniz · WASHINGTON UNIVERSITY · 2024 · $1,803,334 — Abstract: Exercise and mindfulness are believed to be effective stress reduction interventions, but research to date has not been able to assess their benefits while individuals are coping with a major stressor in real time. The COVID-19 pandemic is an unwanted natural experiment in the deleterious …

Understanding and Addressing Food Insecurity and Obesity Among Infant-Parent Dyads

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Colin James Orr · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $202,941 — ABSTRACT The proposed K23 Career Development Award will enable Dr. Colin Orr to become an independent physician- researcher with expertise in food insecurity and childhood obesity prevention. Dr. Orr is a general pediatrician whose long-term goal is to design, test, and implement interventions to ad…

The role of pathogen-experienced macrophage subsets in mediating lung immunity and heterologous protection

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

William Clark Gause · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · 2024 · $773,368 — ABSTRACT: Infections of the lung significantly impact health worldwide, with non-tuberculosis lower respiratory infections causing 2.7 million deaths annually and chronic infections significantly contributing to impaired lung function and morbidity. Pulmonary macrophages are critical, front-line med…

Scaling and Sustaining COVID-19 Vaccination through Meaningful Community Engagement and Care Coordination for Underserved Communities

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Adrienn Borsika Rabin · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $543,599 — PROJECT SUMMARY/ABSTRACT COVID-19 vaccines have been inequitably distributed and vaccine uptake has lagged, particularly for immigrant, refugee, Latino, and Black, Indigenous, People of Color (BIPOC) communities. Underlying reasons for the slow and variable uptake of COVID-19 vaccines include indivi…

Detecting active tuberculosis disease: a blood-based Mycobacterium tuberculosis antigen detection asssay

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Marva Seifert · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $276,500 — Project Summary/Abstract HIV infection directly impacts both Mycobacterium tuberculosis pathogenesis and disease severity. Timely and accurate diagnosis of active tuberculosis (TB) disease is critical for people living with HIV (PLWH) as TB disease accounts for one third of all HIV-related deaths. Y…

Impact of gestational SARS-CoV-2 and maternal inflammation on child growth and neurodevelopment in a malaria-endemic setting

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Karen Blake Jacobson · KAISER FOUNDATION RESEARCH INSTITUTE · 2024 · $193,320 — PROJECT SUMMARY / ABSTRACT Since the emergence of SARS-CoV-2 in 2020, millions of pregnancies in malaria-endemic sub-Saharan Africa have been impacted by SARS-CoV-2 infection. High rates of SARS-CoV-2 and malaria co-infections during pregnancy will continue as new SARS-CoV-2 variants emerge and caus…

Biomarkers and subphenotypes predictive of clinical outcomes in patients with COVID-19 related acute respiratory distress syndrome

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Narges Alipanah-Lechner · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $46,244 — PROJECT SUMMARY/ABSTRACT Acute Respiratory Distress Syndrome (ARDS), caused by a variety of triggers including COVID-19, is a devastating critical illness without effective therapies. Despite numerous studies on COVID-19 related ARDS (CARDS), the best available treatments lead to only modest or inco…

ADAPTING AND ASSESSING THE FEASIBILITY OF A TELEHEALTH DIABETES PREVENTIONPROGRAM FOR HISPANIC ADOLESCENTS

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Erica Soltero · BAYLOR COLLEGE OF MEDICINE · 2024 · $66,012 — Project Summary Hispanic adolescents are disproportionately burdened by type 2 diabetes (T2D) and social determinants of health (SDoH), which can serve as barriers to behavior change and participation in disease prevention efforts. Telehealth is a potentially effective approach for delivering diseas…

Barriers to Screen for Domestic Violence among Women in Emergency Department

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Azade Tabaie · MEDSTAR HEALTH RESEARCH INSTITUTE · 2024 · $432,542 — PROJECT SUMMARY ABSTRACT Domestic violence (DV) includes physical and sexual violence, threats, economic, and emotional/psychological abuse, or other abusive behavior as part of a systematic pattern of control and power perpetrated by one intimate partner against another. It causes a significant bur…

Center to Advance Research Excellence (OPTIC)

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

BRADLEY D STEIN · RAND CORPORATION · 2024 · $110,475 — Abstract Federal and state policymakers, advocates, and community officials have implemented multiple strategies, policies, and initiatives to address dimensions of the rapidly evolving opioid crisis. There has been progress on many fronts, including increased access to medication treatment for opio…

Examining Pathways Between Food Insecurity and Cardiometabolic Health in Diverse Children and Adolescents

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Jerica M Berge · UNIVERSITY OF COLORADO DENVER · 2024 · $89,652 — ABSTRACT Food insecurity is known to be associated with metabolic and cardiovascular disease in adults. However, there is a gap in our knowledge; specifically a lack of studies investigating factors that influence the emergence of cardiometabolic risks from food insecurity during childhood and adole…

NCANDA: Data Analysis Resource - Upgrading Computer System

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Adolf Pfefferbaum · STANFORD UNIVERSITY · 2024 · $149,813 — PROJECT SUMMARY In response to PA-20-272, this supplement requests funds to upgrade the computer infrastructure of the Scalable Informatics for Biomedical Imaging Studies (SIBIS). SIBIS has been daily used by National Consortium on Alcohol and Neurodevelopment in Adolescence to Adulthood (NCANDA-A) …