Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Tongqing Zhou · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $317,422 — An understanding of the serum responses of virus-infected individuals and vaccinees is critical for the development of effective vaccines against HIV-1, SARS-CoV-2 and other viral pathogens. Perhaps the most important biological aspect of a serum response is its neutralizing activity, with a close s…
IRWIN M CHAIKEN · DREXEL UNIVERSITY · 2020 · $74,282 — SUMMARY HIV-1 is the causative agent of AIDS, which remains a global pandemic. The need continues for more effective and broadly active preventive strategies and anti-retroviral therapies to target infectious virus and already- infected cells. In both virus-cell and cell-to-cell infection, the metas…
IRWIN M CHAIKEN · DREXEL UNIVERSITY · 2020 · $345,500 — SUMMARY HIV-1 is the causative agent of AIDS, which remains a global pandemic. The need continues for more effective and broadly active preventive strategies and anti-retroviral therapies to target infectious virus and already- infected cells. In both virus-cell and cell-to-cell infection, the metas…
ALLAN I LEVEY · EMORY UNIVERSITY · 2020 · $1,017,042 — The Open Drug Discovery Center for AD (Open-AD) Structural Biology core aims to provide Target Enabling Packages (TEPs): a combination of experimental tools and knowledge that will allow researchers to investigate the biology of potential drug targets and to test therapeutic hypotheses. The TEPs wil…
ELLIS L REINHERZ · DANA-FARBER CANCER INST · 2020 · $1,289,808 — ABSTRACT There are only a handful of sites on the HIV-1 envelope protein that represent regions of vulnerability for elicitation of broadly neutralizing antibody (BNAbs). Four are associated with the gp120 subunit while one of the sites resides in the membrane proximal external region (MPER) of …
Jason Scott McLellan · UNIVERSITY OF TEXAS AT AUSTIN · 2019 · $613,032 — Coronaviruses have the largest genomes among known RNA viruses and are phylogenetically divided into four genera. Some betacoronaviruses, such as HKU1, circulate annually in humans and cause mild yet prevalent respiratory disease whereas others, such as SARS-CoV and the recently emerged MERS-CoV, ha…
Erik S Welf · UT SOUTHWESTERN MEDICAL CENTER · 2019 · $116,100 — DESCRIPTION (provided by applicant): A greater understanding of the mechanisms mediating melanoma metastasis is necessary for treatment of advanced disease. Because all melanoma cells must move through and survive in non-native tissue microenvironments during metastatic dissemination, the abili…
Rebecca Michelle DuBois · UNIVERSITY OF CALIFORNIA SANTA CRUZ · 2019 · $363,921 — PROJECT SUMMARY Human astroviruses (HAstV) are a leading cause of viral diarrhea in children. Divergent HAstV strains are associated with fatal human encephalitis. Currently, no vaccines or antiviral therapies exist for HAstV infections. Our goal is to identify sites of vulnerability (Achilles' heel…
MARGARET A TITUS · UNIVERSITY OF MINNESOTA · 2019 · $357,741 — Cells migrating in tissues, including cancer cells, use filopodia to guide them through the 3D environment and increased formation of filopodia correlates strongly with the metastatic potential and invasiveness of cancer cells. Filopodia are slender actin-filled projections composed of a core of cro…
Nour Al-muhtasib · YALE UNIVERSITY · 2019 · $61,226 — The overall goal of this proposal is to investigate the role of endocannabinoid (ECB) signaling in regulating distinct cortical inhibitory synapses. Physiological brain development and function are dependent on a fine-tuned balance of synaptic excitation and inhibition. As such, dysregulation of inh…
JOSHUA M KAPLAN · MASSACHUSETTS GENERAL HOSPITAL · 2019 · $588,908 — DESCRIPTION (provided by applicant): The goal of this project is to identify cellular defects that are caused by mutations in genes linked to Autism spectrum disorders (ASD), using the C. elegans neuromuscular junction as a model. In particular, we will test two prominent models for pathophysio…
Margaret M Stratton · UNIVERSITY OF MASSACHUSETTS AMHERST · 2019 · $313,765 — PROJECT SUMMARY How does a memory outlast the lifetime of the molecule that encodes it? More than two decades ago, Francis Crick had the foresight to speculate that perhaps a multimeric protein could serve as a molecular memory by sharing its activation state with newly synthesized proteins through …
Dawn Caster · UNIVERSITY OF LOUISVILLE · 2019 · $165,780 — DESCRIPTION (provided by applicant): Up to 60% of SLE patients develop clinical evidence of kidney injury, termed lupus nephritis (LN). LN is thought to be caused by glomerular immune complex deposition activating an inflammatory cascade that injures glomerular cells, leading to proteinuria and…
Gary R Whittaker · CORNELL UNIVERSITY · 2019 · $235,500 — Project Summary/Abstract We propose to develop a subunit vaccine for MERS-CoV, using a structure-based approach targeting conserved and functionally essential domains in the stalk region of the viral spike protein. MERS-CoV itself is a currently emerging virus in humans with strong links to camels, …
Veronica A Alvarez · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · 2019 · $2,446,560 — Project A: Preclinical mouse model reveals a mechanism linking two known vulnerability factors for alcohol abuse: heightened alcohol stimulation and low striatal dopamine D2 receptors (Study accepted for publication and currently under press in Cell Reports). Alcohol produces both stimulant and sed…
PETER LEON COLLINS · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2019 · $464,780 — We previously constructed a first-generation construct called HPIV3-EbovZ GP, in which the complete genome of the JS strain of HPIV3 was modified by the addition of the EBOV GP gene in the third gene position, between the HPIV3 P and M genes. The JS strain is thought to be an attenuated HPIV3, based…
Thomas Miller Gallagher · UNIVERSITY OF IOWA · 2019 · $266,291 — PROJECT SUMMARY The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a zoonotic virus that can cause fatal disease in patients with underlying comorbidities. Further recognition of this respiratory syndrome and prevention strategies will require a small animal infection model as well as an…
IRWIN M CHAIKEN · DREXEL UNIVERSITY · 2019 · $345,514 — SUMMARY HIV-1 is the causative agent of AIDS, which remains a global pandemic. The need continues for more effective and broadly active preventive strategies and anti-retroviral therapies to target infectious virus and already- infected cells. In both virus-cell and cell-to-cell infection, the metas…
RICK B MEEKER · UNIV OF NORTH CAROLINA CHAPEL HILL · 2019 · $388,750 — HIV infection of the nervous system results in chronic infection, inflammation and cognitive decline in many patients with no effective treatments. Inflammation appears early in the disease process and causes progressive neural damage due, in part, to factors released by activated microglia and macr…
David Veesler · UNIVERSITY OF WASHINGTON · 2019 · $293,325 — Enveloped viruses use specialized proteins present at the virus surface to translocate their genetic material across the host cell membrane during infection. For coronaviruses, homotrimers of the spike glycoprotein promote host cell attachment and fusion of the viral and host membranes. Although cor…