Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Chawangwa Modongo · UNIVERSITY OF CALIFORNIA-IRVINE · 2024 · $565,009 — Project Summary The emergence and spread of SARS-CoV-2 variants of concern is threatening global health and our ability to prevent COVID-19 disease, raising concerns about a potential new wave of the pandemic. HIV may complicate the trajectory of the COVID-19 pandemic and efforts to eradicate the vi…
Alexander Gabriel Fiks · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $866,647 — Problem: Influenza and pneumonia is the #8 leading cause of death among children. The influenza vaccine is on the recommended schedule for children and is effective against severe disease. However, families may have different reasons they chose to vaccinate or not vaccinate their child against influ…
Michael Joseph Peluso · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $664,976 — PROJECT SUMMARY/ABSTRACT Post-acute sequelae of SARS-CoV-2 infection (PASC) can affect multiple organ systems and result in functional impairment. Neurologic PASC symptoms (neuro-PASC) including cognitive impairment, headache, and neuropathy are among the most debilitating. Structural and functional…
Gavin J Sherlock · STANFORD UNIVERSITY · 2024 · $414,751 — Project Summary/Abstract Emerging and endemic viral pathogens are a persistent threat to human health, the global economy, and national readiness. Viral proteins interact with host proteins to hijack host cells and replicate transmissible viral particles. Human-viral and viral-viral protein-protein …
Jason V Baker · UNIVERSITY OF MINNESOTA · 2024 · $671,068 — ABSTRACT Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS- CoV-2) has become a widespread global pandemic. While the predominant clinical manifestation of severe COVID-19 is respiratory failure, other organ complications such as cardiac injury are c…
Jarrod Mousa · FLORIDA STATE UNIVERSITY · 2024 · $690,023 — The goal of this research project is to further the development of a pan-Pneumovirus vaccine and to test our hypothesis that a chimeric Pneumovirus fusion (F) protein vaccine displaying immunodominant epitopes of respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) will induce broad pr…
SCOTT L NUISMER · UNIVERSITY OF IDAHO · 2024 · $335,075 — Each year, millions of people are harmed or killed by pathogens that spill over from wild or domestic animal reservoirs. A new approach to reducing the threat of spillover is to eliminate the pathogen from its animal reservoir using transmissible vaccines that move from animal to animal providing im…
JON HUIBREGTSE · UNIVERSITY OF TEXAS AT AUSTIN · 2024 · $464,326 — SUMMARY Human ISG15 is a ubiquitin-like protein (Ubl) that functions in innate immune responses, and it is remarkable for possessing three distinct biochemical activities. As a ubiquitin-like modifier it is conjugated to hundreds of cellular and viral proteins. The E1, E2, E3, and de-conjugating en…
ERIC Alfred HOFFMAN · UNIVERSITY OF IOWA · 2024 · $2,000,000 — Project Summary/Abstract This is a request to upgrade our current Siemens SOMATOM Force research energy integrating CT scanner to a newly released photon-counting CT scanner (Siemens NAEOTOM Alpha). While we have made great progress in the use of quantitative CT imaging to sub-phenotype lung disease…
Sarita U Patil · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $834,998 — Food allergy affects about 10% of the US population, and its incidence continues to grow. More than 40% of individuals with peanut allergies have experienced life-threatening anaphylaxis, which occurs when allergen binds IgE antibodies to activate allergic effector cells. Immunotherapy for food alle…
Brendesha Marie Tynes · UNIVERSITY OF SOUTHERN CALIFORNIA · 2024 · $884,714 — Traumatic online experiences have become daily stressors in the lives of adolescents. A number of adolescents average 5.2 incidents of negative experiences due to their social position per day, with those occurring online as most frequent. Examples include witnessing calls for genocide, mock lynchin…
NATASHA Bassam HALASA · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $1,234,285 — PROJECT SUMMARY - Mandatory Component A Acute respiratory illness (ARI) and acute gastroenteritis (AGE) are the leading causes of death worldwide in young children. Established leading viral etiologies of AGE are rotavirus and norovirus and respiratory syncytial virus (RSV) and influenza virus for A…
Marc Ghany · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · 2024 · $502,831 — Summary: Chronic infection with the hepatitis C virus (HCV) is a major cause of cirrhosis, decompensated liver disease and hepatocellular carcinoma (HCC) worldwide. Globally there are an estimated 58 million persons with HCV. In the United States (U.S.), 1% of the general population or 2.7 million …
Connie Schmaljohn · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $58,051,257 — The Integrated Research Facility - Frederick (IRF-Frederick) plays a central role in the U.S. Government’s high-containment research on emerging infectious diseases. In FY2024, the IRF-Frederick continued support for COVID-19 research and initiated multiple research studies focused on agents requiri…
michele k evans · NATIONAL INSTITUTE ON AGING · 2024 · $718,611 — The biological and behavioral health disparities research focuses on the HANDLS study. Our work has focused on biological aging and weathering, frailty, biomarkers of aging, mortality, and inflammation. However, our most important recent work has identified Early onset frailty as a surrogate for wea…
Weidong Wang · NATIONAL INSTITUTE ON AGING · 2024 · $180,474 — Our group has discovered Top3b as the first dual-activity topoisomerase in eukaryotes(Xu et al., Nat. Neurosci., 2013). This discovery has greatly expanded the topoisomerase field, because it suggests that not only DNA, but also RNA, may have topological problems that require topoisomerases to solve…
ELEANOR Marie SIMONSICK · NATIONAL INSTITUTE ON AGING · 2024 · $8,568,920 — The Baltimore Longitudinal Study of Aging (BLSA), the major research program on human aging supported by the Intramural Research Program of the NIA, was established in 1958 and conducted at the Gerontology Research Center through 2003. Beginning in 2003 a new research unit was established at Harbor…
Philippe Youkharibache · DIVISION OF BASIC SCIENCES - NCI · 2024 · $42,813 — A significant part of my recent research efforts is focused on studying self-association determinants of molecular systems as revealed by their structural symmetries at several levels: from proteins assemblies to their protein supersecondary structures constituents (protodomains) [Youkharibache 2019…
Augustin Luna · NATIONAL LIBRARY OF MEDICINE · 2024 · $882,387 — 1. Computational Analysis of Sarcoma Pharmacogenomics Sarcomas are a diverse group of rare malignancies composed of multiple different clinical and molecular subtypes. Due to their rarity and heterogeneity, basic, translational, and clinical research in sarcoma has trailed behind that of other cance…
Pamela Schwartzberg · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $29,037 — In order to evaluate human immune responses in depth, I helped initiate and coordinate one of the initial studies from the NIH Center for Human Immunology, which focused on immune responses to vaccination for influenza. This study was designed to help build a data base of normal human variation (the…