Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Bibiana Bielekova · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $1,388,137 — Neuroimmunological diseases of the central nervous system (CNS) represent a growing spectrum of diagnoses, most of which are considered rare disorders. The pathophysiology of these diseases is poorly understood, and effective therapies are sporadic. The most common immune-mediated CNS disease is mul…
Carol R Horowitz · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $1,250,000 — Since 2016, the All of Us Research Program (AoURP) has striven to build the foundation for major advancements in precision medicine. Mount Sinai will continue to maintain regulatory requirements, continue its engagement and retention efforts, and achieve EHR milestones to contribute to All of Us’ na…
Matthew Hall · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · 2024 · $500,000 — 1.The Target-Based Assays 1 (Martinez) Group has identified and prioritized viral targets amenable for therapeutic intervention via small molecule modulation, including endonucleases, exonuclease, proteases, and methyltransferases. Candidate compounds resulting from each assay will be screened in li…
Rick A Bevins · UNIVERSITY OF NEBRASKA LINCOLN · 2024 · $1,793,862 — Treatment and prevention of women’s substance use lags that of men, and interventions designed for men are often ineffective for women. Much prior work has failed to account for unique contextual factors related to young women’s substance use: relative to men, women report greater stress-induced and…
Wendy PrudhommeOMeara · DUKE UNIVERSITY · 2024 · $60,227 — ABSTRACT Plasmodium vivax has not traditionally been considered in malaria elimination strategies across Africa, due to the assumption that its transmission cannot be supported in the predominantly Duffy-negative population. Nevertheless, there is growing evidence that P.vivax is present across the …
Daiane Borges Machado · FUNDACAO OSWALDO CRUZ · 2024 · $382,592 — PROJECT SUMMARY Physical, emotional, and social changes, including exposure to poverty, abuse, or violence, increases youth vulnerability to mental illness. These factors interfere with development, limit opportunities, and hamper achievement of a fulfilling life as adults. Addressing these issues c…
Jason Knight · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $396,640 — PROJECT SUMMARY/ABSTRACT This proposed renewal of “Purinergic modulation of the autoimmune vascular phenotype” builds upon 4 years of discovery by an early stage investigator in the areas of lupus, COVID-19, and antiphospholipid syndrome (APS). Despite the routine use of traditional anticoagulants i…
Vicki Fung · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $526,296 — Many Medicaid expansion enrollees with incomes less than 138% of the federal poverty level (FPL) face greater cost-sharing and higher out-of-pocket costs when they tum 65 years old and transition to Medicare. In Medicare, there is a subsidy cliff at 100% FPL, above which beneficiaries are not eligib…
RORY A. COOPER · VETERANS HEALTH ADMINISTRATION · 2024 — Veterans who use wheelchairs are often prescribed physical activity (PA) in an effort to manage weight and improve cardiovascular health and function however few wheelchair users are currently meeting the recommended amounts of moderate to vigorous aerobic activity (3 times per week ~30 minutes per …
Z Hong ZHOU · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $456,167 — Double-stranded RNA (dsRNA) viruses comprise a large group of non-enveloped viruses characterized by their ability to transcribe their RNA within an intact capsid (i.e., endogenous RNA transcription), thus evading cellular antiviral responses to dsRNA. Among them, members of the Reoviridae family of…
Junjie Yao · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $611,361 — Abstract Thrombosis, the obstruction of blood flow due to the formation of clot in blood vessels, accounts for 1 in 4 deaths worldwide. In particular, venous thrombi occur in deep veins most often in the legs or arms and is commonly known as deep vein thrombosis (DVT). DVT and pulmonary embolism are…
Hussein Al-Khalidi · DUKE UNIVERSITY · 2024 · $1,680,466 — Project Summary: Urinary Stone Disease (USD) is an increasingly prevalent and highly recurrent condition associated with major morbidity at a rising cost to society. Thus, improved management can significantly reduce its health burden. Increasing fluid intake is recommended to all USD patients. Howe…
Bernard P. Chang · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $756,453 — Over the past year, the entire world has been upended by the COVID-19 pandemic. As of February 2021, there have been over 112 million confirmed cases and over 2.5 million deaths globally. In New York City, the initial US epicenter of the pandemic, there have been >700,000 cases, >89,000 hospitalizat…
ANEEL K. AGGARWAL · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $211,250 — Project Summary The Zika virus (ZIKV) is a member of the Flavivirus genus that includes other arthropod-borne human pathogens such as dengue virus and West Nile virus, among others. ZIKV’s link to microcephaly in newborn infants and the Guillan-Barré syndrome in adults has invigorated measures to de…
Philipp W Messer · CORNELL UNIVERSITY · 2024 · $435,571 — Project Summary. Rapid evolution lies at the core of some of the greatest challenges humanity faces today, ranging from the evolution of drug and antibiotic resistance to the rapid emergence of new Covid variants. Researchers are now envisioning even faster evolutionary dynamics brought about by CRI…
Nelson Scott Howard · CASE WESTERN RESERVE UNIVERSITY · 2024 · $188,918 — Project Summary Aerosol-generating procedures (AGPs) are medical procedures that produce aerosols that can be laden with pathogens if the patient has a viral infection, such as SARS-CoV-2 or influenza. These aerosols pose a significant risk to health care workers, as they can linger in the air for ext…
Hu Zeng · MAYO CLINIC ROCHESTER · 2024 · $470,828 — Project Summary Amino acids are crucial nutrients that are also important to support immunity. Yet, we have limited understanding with regard to how immune challenges modulate amino acid availability, and how immune cells sense amino acid and transduce the signals to execute immune reponses. Rag-GTP…
HEATHER R DESAIRE · UNIVERSITY OF KANSAS LAWRENCE · 2024 · $2,261,838 — Summary Through this new NIH-funded biomedical center at the University of Kansas (KU), we aspire to leverage big data to improve women’s health. A strong and diverse inaugural group of Research Project Leaders, spanning the laboratory sciences and social/behavioral sciences would lead the research.…
KAI ZHAO · OHIO STATE UNIVERSITY · 2024 · $506,056 — Project Summary Since its outbreak in China in December 2019, the global impact of SARS-CoV-2 infection has been extraordinary, with over 350 million cases and more than 5.5 million lives lost (WHO Coronavirus Dashboard, Jan 2022). Despite various public health measures, such as social distancing, …
Peter B. Gilbert · FRED HUTCHINSON CANCER CENTER · 2024 · $536,488 — PROJECT SUMMARY (See instructions): Safe and efficacious vaccines are needed to massively reduce the economic and human health costs of HIV-1/AIDS, dengue, malaria, and COVID-19. This goal has been hindered by the genetic diversity of the etiological pathogens. Randomized, controlled trials that rig…