Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Peter Daszak · ECOHEALTH ALLIANCE, INC. · 2019 · $661,980 — Project Summary: Understanding the Risk of Bat Coronavirus Emergence Novel zoonotic, bat-origin CoVs are a significant threat to global health and food security, as the cause of SARS in China in 2002, the ongoing outbreak of MERS, and of a newly emerged Swine Acute Diarrhea Syndrome in China. In a p…
LESLIE B GORDON · PROGERIA RESEARCH FOUNDATION, INC. · 2019 · $243,185 — Abstract: Introduction: Hutchinson-Gilford progeria syndrome (HGPS) is a rare, fatal, autosomal dominant premature aging disease with no approved treatment. It is caused by the production of progerin, an abnormal form of the inner nuclear membrane protein, lamin A. Progerin acts as a dominant negati…
Kazutoshi Nakazawa · SOUTHERN RESEARCH INSTITUTE · 2019 · $807,074 — Abstract Abnormal neuronal synchrony at gamma range, often observed in schizophrenia, may be associated with cognitive deficits. Although evidence suggests that cortical fast-spiking interneurons targeting pyramidal cells may be involved in neuronal synchrony, cellular basis of abnormal neuronal syn…
Susan Daniel · CORNELL UNIVERSITY · 2019 · $523,463 — Project Summary / Abstract Enveloped viruses access their host cells by binding to receptors on the plasma membrane and then undergoing fusion with the host membrane. Both binding and fusion are mediated by a specific viral “spike” protein that is typically primed for fusion activation by proteolyti…
Mikhail G Kolonin · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 2019 · $368,900 — White adipose tissue (WAT) is the main lipid reservoir that becomes dysfunctional in obesity. It is important to understand how breached lipid homeostasis leads to metabolic disease. Efficient long chain fatty acid (FA) and cholesterol trafficking depends on a transmembrane transporter protein CD36.…
Bidadi Venkataram Prasad · BAYLOR COLLEGE OF MEDICINE · 2019 · $676,153 — The long-term goal of our research is to understand the structural basis of the complex processes that regulate the replication cycle of rotaviruses (RVs), which are the global pathogens causing life-threatening infantile gastroenteritis. During 2013-2016, our studies have answered several questions…
Kimberly Frances Raab-Graham · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2019 · $335,999 — PROJECT SUMMARY Overview: The project focuses on understanding the molecular basis of how disrupted calcium homeostasis leads to disrupted hippocampal network activity that results in maladaptive responses in neurons with TSC deficient signaling. Approximately 33% of children who have autism spectru…
Lanying Du · NEW YORK BLOOD CENTER · 2019 · $555,526 — DESCRIPTION (provided by applicant): The recurrent outbreak of deadly infectious diseases worldwide heightens the urgency to develop new and improved vaccines to combat their spread. Unfortunately, many of the current vaccines, or those in development, induce suboptimal immune responses and req…
David Veesler · UNIVERSITY OF WASHINGTON · 2019 · $89,600 — Enveloped viruses use specialized proteins present at the virus surface to translocate their genetic material across the host cell membrane during infection. For coronaviruses, homotrimers of the spike glycoprotein promote host cell attachment and fusion of the viral and host membranes. Although cor…
MARGARET A TITUS · UNIVERSITY OF MINNESOTA · 2019 · $40,292 — Cells migrating in tissues, including cancer cells, use filopodia to guide them through the 3D environment and increased formation of filopodia correlates strongly with the metastatic potential and invasiveness of cancer cells. Filopodia are slender actin-filled projections composed of a core of cro…
Barney Graham · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2019 · $951,522 — When the MERS CoV outbreak raised global health concerns, we initiated a program to develop a candidate vaccine. Starting from Spike glycoprotein (S) sequences, we developed an immunization strategy consisting of a full-length S DNA prime and a S1 subunit protein boost that elicited high titers of n…
Stephen Mark Tompkins · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $387,318 — Summary/Abstract Robust animal models of coronavirus infection are required for pre-clinical assessment of candidate vaccines and therapeutic antibodies to prevent coronavirus infection and disease. The goal of the Animal Model Core is to provide a central resource of animal models and virological t…
Adolfo Garcia-Sastre · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $186,142 — PROJECT SUMMARY/ABSTRACT The SYBIL Data Management and Bioinformatics Core (DMBC) will support the Center's mission at all stages of research and publication by tracking projects and experiments, facilitating reproducible analysis, developing bioinformatic tools, and ensuring access and disseminatio…
Olivier Elemento · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · 2024 · $110,787 — Data Management Core Principal Investigator: Olivier Elemento, PhD. Co-I: Zhengming Chen, PhD Abstract This Core will provide bioinformatics expertise and support with data integration and analyses. The Core will serve three main goals. First, it will provide central data storage and data management…
JOHN P. KIRWAN · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · 2024 · $479,565 — The LA CaTS Center Administrative Core has been set up to promote, support, and continually evolve the governance and administrative structure of the Center, to effectively facilitate the necessary leadership, tools and processes required to integrate and align the Cores of the Center and accomplish…
PETER MYLER · SEATTLE CHILDREN'S HOSPITAL · 2024 · $3,166,598 — To apply state-of-the-art, high-throughput structural biology technologies to experimentally characterize the three-dimensional atomic structure of targeted proteins on the NIAID priority pathogens list and organisms causing emerging and re-emerging infectious diseases. This program also supports re…
Diana Montserrat Sheehan · FLORIDA INTERNATIONAL UNIVERSITY · 2024 · $387,882 — FIU-RCMI Research Project #3 Abstract The twin pandemics of human immunodeficiency virus (HIV) and COVID-19 share uncanny similarities with respect to racial/ethnic and socioeconomic disparities in both incidence and mortality. Structural strategies for HIV and COVID-19 outcomes could augment curren…
KAREN M RIDGE · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $500,363 — PROJECT SUMMARY PROJECT 1 Severe viral pneumonia, due to influenza A virus (IAV) damages the lower respiratory tract to cause acute respiratory distress syndrome (ARDS). The persistence of respiratory failure in patients with ARDS is a consequence of persistent inflammation and the failure of normal…
Scott Alderman · DUKE UNIVERSITY · 2024 · $895,157 — ABSTRACT – BSL-3 Practices Core (Core 2) The central mission of the Regional Biocontainment Laboratory Network is to provide a location and an environment in which groundbreaking research on potentially dangerous pathogens can be performed safely. As anyone with the responsibility of managing a lead…
NATIONAL CANCER INSTITUTE · 2024 · $190,000 — In May 2020, in response to the rapidly expanding pandemic caused by the SARS-CoV-2 virus, the National Cancer Institute (NCI) and the National Institute of Biomedical Imaging and Bioengineering (NIBIB) launched a program called Digital Health Solutions for COVID-19. The goal of this initiative was …