Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Silvia Balbo · UNIVERSITY OF MINNESOTA · 2024 · $559,809 — Ethyl alcohol (henceforth ethanol) is a human carcinogen.1,2 Its consumption has been associated with cancers at various sites, including the oral cavity. Despite strong epidemiological evidence, the mechanisms of ethanol carcinogenicity remain unclear, hampering the ability to develop efficacious p…
Magdalena Cerda · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $998,506 — Overdose has risen sharply during the COVID-19 pandemic, highlighting an urgent need to understand the impact of disasters on overdose. We need research to identify the types of policy measures that can prevent a similar increase in overdose in future disasters. We also need to understand why certai…
Jacques E. Chelly · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $238,500 — PROJECT SUMMARY: Postoperative opioid prescription is an important contributor to the opioid epidemic, affecting ~4% of >50 million Americans undergoing surgery each year. The dose and duration of treatment with opioids in surgical patients is an established risk factor of opioid use disorder (OUD) …
Andrea Tara Obi · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $607,566 — PROJECT SUMMARY / ABSTRACT Excessive endothelial inflammation, ‘endotheliitis,’ is a hallmark pathologic feature of severe SARs-CoV2 infection. The sequalae of endotheliitis, such as microthrombosis and tissue hyperpermeability, culminate in a maladaptive host response characterized by interstitial …
Rinad Sary Beidas · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $764,545 — Firearms are now the leading cause of death for young people in the United States, with stark inequities for young people from minoritized communities (e.g., race, ethnicity, LGTBQ+ populations). Secure firearm storage programs are evidence-based, low-cost, scalable, and non-politically divisive. Cu…
Andre Hoelz · CALIFORNIA INSTITUTE OF TECHNOLOGY · 2024 · $376,883 — TITLE Molecular basis of mRNA export ABSTRACT In eukaryotes, the genetic information encoded in the chromatin is stored within the nucleus. For genetic programs to be executed, folded proteins, ribonucleic acids, and assembled macromolecular complexes must be transported across the nuclear envelope.…
Tamar Schlick · NEW YORK UNIVERSITY · 2024 · $125,000 — Bridging Disparate Structural/Functional Scales: Multiscale Modeling of Genome Organization and of Viral RNA Frameshifting Project Summary May 22, 2024 As advances in both experimental and computational biology lead to exciting discoveries in many fields of biology and biomedicine today, new avenu…
David P Miller · DIGITAL HEALTH NAVIGATION SOLUTIONS, LLC · 2024 · $938,786 — Over 30% of age-eligible Americans fail to receive recommended screening for colorectal cancer (CRC), the second leading cause of cancer death in the United States. Multilevel barriers explain why so many Americans fail to receive routine CRC screening. Patients report a lack of knowledge about the …
JACOB E KOHLMEIER · EMORY UNIVERSITY · 2024 · $640,735 — PROJECT SUMMARY / ABSTRACT Respiratory virus infection and intranasal immunization generates antigen-specific T cell and B cell memory throughout the respiratory tract. This includes a population of tissue-resident memory T cells (TRM) that are uniquely positioned within the mucosa to rapidly recogn…
Gregory Seumois · SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE · 2024 · $487,917 — Disease associated with allergies such as asthma are a rising health problem with no current curative solutions. CD4+ helper T cells (TH) that respond to common allergens play an important role in driving airway inflammation in asthma. To better understand the diversity of T cell subsets in allergy …
John Damon Chodera · SLOAN-KETTERING INST CAN RESEARCH · 2024 · $528,000 — PROJECT SUMMARY/ABSTRACT - Overall SARS-CoV-2 continues to cause severe morbidity and mortality in the ongoing pandemic. Future RNA virus epidemics and pandemics are inevitable. New clinical-trial-ready antivirals are urgently needed RNA viruses of pandemic potential. COVID-19 has further underscore…
Matthew Nassar · BROWN UNIVERSITY · 2024 · $85,484 — Project Abstract Humans display tremendous flexibility in their everyday behavior, adjusting it rapidly when appropriate (i.e. adopting mask wearing after onset of Covid-19), but not when inappropriate (i.e. continuing to drive after involvement in an unavoidable car accident). Recent work has highl…
Megan Culler Freeman · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $62,858 — Megan Freeman, MD, PhD, is a Pediatric Infectious Diseases (ID) Fellow at the University of Pittsburgh Medical Center (UPMC) Children’s Hospital of Pittsburgh (CHP). She earned MD and PhD degrees at Vanderbilt University where she investigated the cell biology and pathogenesis of coronavirus infecti…
ROBERT A BRITTON · BAYLOR COLLEGE OF MEDICINE · 2024 · $119,807 — Overall Project Summary The ability to control bacterial infections with antibiotics has been one of the most important public health advancements in human history. Before the discovery of antibiotics and vaccines, infectious disease was the leading cause of death and constituted nearly 50% of death…
Krzysztof Palczewski · UNIVERSITY OF CALIFORNIA-IRVINE · 2024 · $594,265 — SUMMARY Inherited retinal disorders are a genetically heterogeneous group of blinding diseases that have significant impact on quality of life. Therapeutic approaches have lagged significantly behind initial identification of the genetic bases for these diseases. However, there are some striking suc…
Ana Fernandez-Sesma · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $2,265,730 — SUMMARY The Viral Immunity and Vaccination (VIVA) Human Immunology Project Consortium (HIPC) will carry out a comprehensive systems immunology program to assess the dynamic human immune response to SARS-CoV- 2, seasonal influenza viruses and tetravalent and trivalent dengue vaccines and subsequent i…
REBECCA L SUDORE · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $184,569 — PROJECT ABSTRACT The aims of this proposal are to (1) enable the candidate to further develop her research program focused on improving advance care planning (ACP) and medical decision making for older adults, particularly historically marginalized individuals and persons with limited health literac…
REANNE FRANK · OHIO STATE UNIVERSITY · 2024 · $185,603 — Project Summary This project focuses on whether the COVID-19 pandemic has put the well-established Hispanic infant health advantage in peril. The U.S. Hispanic population has been one of the hardest hit by the COVID-19 pandemic with some of the highest rates of hospitalization, death, and illness, d…
Fay Kastrinos · UNIVERSITY OF CHICAGO · 2024 · $701,911 — PROJECT SUMMARY/ABSTRACT Lynch syndrome (LS), the most common inherited cause of colorectal cancer (CRC) affecting ~1.2 million Amer- icans, carries 3-8x higher lifetime CRC risk than the general population. Colonoscopy starting early in adulthood and repeated yearly or biennially is the only recomm…
Dan Li · YALE UNIVERSITY · 2024 · $52,694 — PROJECT SUMMARY/ABSTRACT While progress has been made since the onset of the COVID-19 pandemic, the spread of the virus still poses a threat to school safety. There is a significant concern regarding viral transmission in K-12 schools as a result of close social interactions between children, crowde…