Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Darrell J Irvine · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2024 · $469,443 — Project Summary/Abstract The majority of licensed vaccines are thought to elicit protection mediated by humoral immunity. A key determinant of the specificity and affinity of the antibody response is the germinal center (GC) response elicited by immunization, wherein B cells enter GCs to undergo cyc…
Steve W. C. Chang · UNIVERSITY OF ARIZONA · 2024 · $651,458 — ABSTRACT Adolescence is a time of substantial development attributed to the maturation of brain circuits that underlie the acquisition of new cognitive, emotional, and social skills. It is also a time of maximum vulnerability for mental disorders. In the past decade, the incidence of anxiety, depres…
Nitesh K Kunda · ST. JOHN'S UNIVERSITY · 2024 · $164,000 — Summary Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) is a highly infectious virus known to cause the 2019 coronavirus disease (COVID-19). The disease has been declared as a global pandemic by the World Health Organization. In the United States, as of January 20, 2021, we have more th…
Jennifer Hadlock · INSTITUTE FOR SYSTEMS BIOLOGY · 2024 · $103,762 — Project Summary Post-acute sequelae of COVID-19 (PASC), colloquially known as long covid, has been reported in 31%-69% of COVID-19 patients. The prevalence of PASC among patients, even those with mild infection, and those with prior vaccination, underscores the importance of principled approaches fo…
Nicolai Lehnert · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $481,657 — ABSTRACT Therapeutic use of nitric oxide (NO) gas has several important applications in medicine. Inhaled NO (INO) has become a mainstay of intensive care for lung failure patients. As a pulmonary vasodilator, INO is essential in neonatology, lung transplantation, and pulmonary hypertension. As an i…
Donal O'Mathuna · OHIO STATE UNIVERSITY · 2024 · $242,407 — Project Summary/Abstract One Health research is a field of international health research which recognizes the complex interconnectedness of human, animal, plant, microbial and environmental health. It takes an interdisciplinary approach to respond to global health needs in the search for causes, pre…
Robert Blair · TULANE UNIVERSITY OF LOUISIANA · 2024 · $192,001 — PROJECT SUMMARY Vaping is a serious public health concern that was associated with outbreaks of hospitalizations and deaths in 2019. These outbreaks of electronic vaping associated lung injury (EVALI) coincided with increased use of electronic vaping devices by adolescents and young adults. The rapi…
ANANT K MENON · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $470,047 — Protein glycosylation is essential in all eukaryotes, from disease-causing protists such as malaria, to yeast and mammals. Secretory proteins are N-glycosylated, O- and C-mannosylated, and/or glycosylphosphatidylinositol (GPI)-anchored as they enter the lumen of the endoplasmic reticulum (ER). Yeast…
Thomas P Giordano · BAYLOR COLLEGE OF MEDICINE · 2024 · $1,000,000 — PROJECT SUMMARY – TEXAS DEVELOPMENTAL CENTER FOR AIDS RESEARCH In 2019, the US announced a plan to End the HIV Epidemic by 2030. To be successful, strategies that improve HIV prevention and HIV treatment outcomes are needed. Only 56% of people with HIV (PWH) were virally suppressed in 2018, a critic…
Dipankar Gupta · EMOCHA MOBILE HEALTH, INC. · 2024 · $837,410 — Few interventions have proven to be successful in promoting medication adherence and impacting short- and long-term posttransplant outcomes in adolescent heart transplant (HT) recipients. Improving adherence is a persistent challenge with youth experiencing chronic health conditions, especially amon…
SAMUEL I. PARRY · UNIVERSITY OF PENNSYLVANIA · 2024 · $357,498 — Abstract The University of Pennsylvania's Department of Obstetrics and Gynecology reflects a long tradition of excellence in clinical and translational research. In this application, information is provided on the obstetrical service and proven track record for conducting clinical trials at two hosp…
ELLIOTT D CROUSER · OHIO STATE UNIVERSITY · 2024 · $494,210 — The SARS CoV-2 pandemic has resulted in >550,000 deaths in the USA alone. Therapeutic options for critically ill patients with COVID-19 are limited. Prior studies showed that development of severe hypoxemia and lung inflammation in influenza A virus-infected mice is associated with inhibition of de …
Timothy E Corcoran · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $198,750 — ABSTRACT: Ventilator associated pneumonias (VAP) are a common complication in mechanically ventilated patients, occurring more than 250,000 times annually. VAPs occur in a high percentage of mechanically ventilated patients with acute respiratory distress syndrome (ARDS, 29%) and COVID-19 (>50%). Ti…
RAYMOND T CHUNG · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $2,446,152 — Program Summary While we have learned a tremendous amount about human immune responses in recent years, many studies of human immunology examine the system in a static state of health or disease. However, to truly define how a complex system works, dissect the components that interact with each othe…
Joey H. T. Li · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $44,651 — PROJECT SUMMARY NK cells are required for antiviral immunity against viral infection in mice and humans. Patients with NK cell deficiencies display increased susceptibility to infection from human cytomegalovirus (HCMV), varicella zoster virus, and other herpesviruses. During the response to viral i…
Erik Rolando Duboue · FLORIDA ATLANTIC UNIVERSITY · 2024 · $5,000 — Project Summary/Abstract A central goal of biological research is to understand how the diversity seen throughout fauna is generated, and how changes in environment and ecology lead to phenotypic differences. Naturally occurring genetic variation has instrumental roles in driving phenotypic differen…
Megan Adkins Adams · VETERANS HEALTH ADMINISTRATION · 2024 — Background: Recently, VA underwent two unprecedented disruptive changes that fundamentally altered how care is delivered to Veterans. First, the VA MISSION Act was implemented in June 2019. Arguably the biggest policy change in VA care delivery since the "Kizer revolution,” MISSION’s purpose is to i…
Joseph Servadio · TEMPLE UNIV OF THE COMMONWEALTH · 2024 · $76,756 — PROJECT SUMMARY Influenza is a persistent viral disease worldwide, with high case counts leading to deaths and losses in productivity yearly. In temperate regions of the world, such as the United States, influenza appears in annual wintertime cycles, with the influences of changing seasons creating …
Carla J Berg · GEORGE WASHINGTON UNIVERSITY · 2024 · $454,860 — PROJECT SUMMARY A key Healthy People 2030 Tobacco-Use Objective is to eliminate state preemption of local tobacco control. However, little published research has rigorously quantified the impacts of state preemption of local tobacco control, particularly: 1) across states and over time; 2) across a …
Phuong-Uyen C Dinh · NORTH CAROLINA STATE UNIVERSITY RALEIGH · 2024 · $368,788 — PROJECT ABSTRACT Idiopathic pulmonary fibrosis (IPF) is an ultimately fatal disease whose only curative treatment is lung transplant. IPF is characterized by formation of fibrotic lesions in the lung, eventually resulting in scarring and progressive loss of lung function. Despite some newer treatmen…