Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Cameron S. Carter · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $530,926 — PROJECT SUMMARY – PROJECT 5 Evidence from epidemiology implicates gestational maternal immune activation (MIA) in the pathophysiology of schizophrenia (SZ). These data, together with recent advances in our understanding of the role of immune molecules in normal brain development, have led to the ove…
Margaret Weiss · CAMBRIDGE HEALTH ALLIANCE · 2024 · $144,662 — PROJECT SUMMARY AND ABSTRACT – Cambridge Health Alliance ALACRITY for Early Screening and Treatment of High Risk Youth (eSToRY) R34 Prevention and Early Identification for High Risk Youth in School-based Clinics The proposed project aims to implement and test tools necessary to prevent transitions t…
Maryam Raeeszadeh Sarmazdeh · UNIVERSITY OF NEVADA RENO · 2024 · $187,308 — PROJECT SUMMARY/ABSTRACT We have shown that specific members of the matrix metalloproteinase family (MMP-2 and MMP-9) are overexpressed in preterm laboring myometrium and that these enzymes exacerbate contractile responses in human uterine smooth muscle. Therefore, MMP-2/9 may serve as therapeutic t…
Ira J Goldberg · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $811,326 — ABSTRACT The first steps in atherosclerosis are the transendothelial movement and subendothelial accumulation of lipoprotein lipid. Endothelial cell (EC) transcytosis of LDL involves two receptors, scavenger receptor-BI (SR-BI) and activin-like kinase 1 (ALK1). We showed that ECs also internalize un…
Wesley B Grueber · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $135,000 — PROJECT SUMMARY This application is for a competitive renewal of R25 NS076445 to fund “Summer Program for Under- represented Students (SPURS)”, to be renamed “Summer Program for Undergraduate Rising Stars (SPURS)”, through the RFA-HL-21-168 mechanism. 100% of the proposed funding will be used to sup…
MICHAEL FINLEY SUMMERS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · 2024 · $754,566 — 7. Project Summary/Abstract The overall goal of this project is to understand how the HIV-1 5′-leader RNA differentially directs diverse functions during viral replication, including intracellular trafficking, initiation of translation, recruitment of viral structural proteins (called Gag), and nucl…
Martin Paukert · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · 2024 · $193,750 — We propose to investigate a novel form of microglia Ca2+ signal that we have discovered in awake behaving mice. It is the first microglia Ca2+ signal identified so far that represents a direct response to active, vigilant behavior and neuronal activity within short latency (<10 seconds). Due to the …
Irina Matei · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $188,198 — ABSTRACT Cancer progression and metastasis account for the majority of cancer- related deaths, yet how cancer overcomes the immune system to metastasize is only beginning to be understood. The promise of immunotherapies has underscored how integral the host immune cells are in controlling cancer pro…
Emily Suzanne Gurley · JOHNS HOPKINS UNIVERSITY · 2024 · $666,608 — Abstract Until and unless we better understand and prevent spillovers of bat-borne viruses into intermediate hosts and humans, we will be severely limited in our ability to stop pandemics. Henipaviruses are bat-borne, RNA viruses that spillover through this route. Nearly half of all reported human h…
Manhattan E Charurat · UNIVERSITY OF MARYLAND BALTIMORE · 2024 · $313,674 — Abstract of research The finding that most patients with virologic failure (HIV-1 RNA >=1,000cp/mL) on second-line PI- containing regimens lack PI-resistance mutations in the protease (PR) gene is one of the main enigmas of antiretroviral drug resistance research. We hypothesized that env and gag se…
Jie Sun · UNIVERSITY OF VIRGINIA · 2024 · $569,694 — Summary/Abstract Tissue-resident memory T cells (TRM) that park within the non-lymphoid tissue provide superior immunity against a variety of pathogens including influenza virus infection. The mechanisms regulating CD8 TRM maintenance, heterogeneity, protective and pathological functions are incompl…
Mei Wan · JOHNS HOPKINS UNIVERSITY · 2024 · $409,375 — Summary To date, targeting the genes regulating intrinsic axon growth ability have produced by far the most promising results in optic nerve regeneration. Recent studies, including ours, have provided strong evidence that neuronal aging might be a key converging process underlying the loss of intrin…
Debra Parker Oliver · WASHINGTON UNIVERSITY · 2024 · $732,899 — Caregiver Speaks: A Technologically Mediated Storytelling Intervention for Family Caregivers of Individuals with Alzheimer’s Disease and Other Dementias ABSTRACT This randomized controlled trial will test an intervention for an understudied population – family caregivers of persons living with deme…
Vaithilingaraja Arumugaswami · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $520,349 — PROJECT SUMMARY: Zika virus (ZIKV) is a teratogenic human pathogen that causes congenital eye and brain diseases. Affected babies exhibit vision impairment and associated ocular pathology, including loss of foveal reflex and macular pigment mottling, chorioretinal scarring, and macular atrophy. ZIKV…
Lior Rennert · CLEMSON UNIVERSITY · 2024 · $629,335 — Project Summary Black, Hispanic, and rural Americans are twice as likely to die from Coronavirus Disease 2019 (Covid-19). These health disparities have been fueled by inadequate access to essential resources throughout the pandemic. Such inequities are not unique to Covid-19. Over the past century, …
JOANNE E. CURRAN · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · 2024 · $500,383 — PROJECT SUMMARY Type 2 diabetes is a major public health concern. Diabetes currently affects 25.8 million people in the US alone and 90-95% of all cases are type 2. There are many complications related to diabetes, including a significantly increased risk of heart disease and stroke, blindness, kidn…
Lev Becker · UNIVERSITY OF CHICAGO · 2024 · $490,784 — ABSTRACT Visceral obesity associates with insulin resistance and chronic inflammation, which are major risk factors for the metabolic syndrome, diabetes, and cardiovascular disease. Although the cellular hallmark of obesity is neutral lipid expansion in adipocytes, adipose tissue of obese mice and h…
Chenxiang Lin · YALE UNIVERSITY · 2024 · $522,742 — Project Summary This project aims to understand in molecular detail how fluid shear stress acting on endothelial cells triggers mechanical activation of signaling pathways at cell-cell junctions. Published data show that shear stress activates a PECAM1-dependent signaling pathway, Notch signaling an…
Donald M. Caspary · SOUTHERN ILLINOIS UNIVERSITY SCH OF MED · 2024 · $559,289 — PROJECT SUMMARY Age-related hearing loss (ARHL) is a complex disorder affecting between 50-70% of the United States population aged 65 or older. In public settings, seniors frequently have great difficulty understanding speech, which can lead to withdrawal from social activities, depression and cogn…
Joshua D Brody · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $368,346 — PROJECT SUMMARY: Checkpoint blockade has had tremendous impact on cancer therapy, but only a subset of patients respond. While non-response may be due to lack of tumor-associated antigen (TAA), our group and others have shown that –as important as having TAA– is the immune system’s capacity to prese…