Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Elizabeth Lane · HARVARD MEDICAL SCHOOL · 2024 · $81,892 — Summary/abstract Cystic Fibrosis (CF) is genetic disorder that effects approximately 30,000 people in the United states and more then 70,000 worldwide. CF is caused by mutations in the epithelial chloride channel CF transmembrane conductance regulator (CFTR) gene. In CF, loss-of-function mutations i…
KENNETH M KAUFMAN · CINCINNATI VA MEDICAL CENTER RESEARCH · 2024 — The new Covid-19 virus is deadly for 0.2% to 4% of people infected, with older men the most severely afflicted with this scourge, being mortal to ~15% of those infected over 80 years, making the US Veteran population especially vulnerable. It is critically important to understand the mechanisms of t…
Hongying Daisy Dai · UNIVERSITY OF NEBRASKA MEDICAL CENTER · 2024 · $236,947 — Project Summary Marijuana use among youth has been increasing, with considerably enlarged disparities across racial/ethnic groups. Racial minorities like African American (AA) adolescents are more likely to report marijuana use than their White peers. Marijuana use during adolescence can harm brain…
Arielle Hope Sheftall · UNIVERSITY OF ROCHESTER · 2024 · $156,000 — PROJECT SUMMARY/ABSTRACT Suicide is the fifth leading cause of death among U.S. children 5 to 12 years, yet limited research on childhood suicide and suicidal behavior (SB) exists. The National Institute of Mental Health (NIMH) has acknowledged this critical gap as a high research priority. A signif…
Sumati Gupta · VA SALT LAKE CITY HEALTHCARE SYSTEM · 2024 — Bladder cancer is the most common urinary tract cancer in men. The cumulative effects of smoking and deployment-related carcinogens in the aging Veteran population play a major role in the pathogenesis of bladder cancer. The recurring and progressive nature of bladder cancer poses a significant heal…
ERIC G. SMITH · EDITH NOURSE ROGERS MEMORIAL VETERANS HOSPITAL · 2024 — Background: VA use of prescribed stimulants (PS) has been skyrocketing. PS are beneficial for many Veterans but can also cause serious risks ranging from cardiac problems, psychosis, mania, substance abuse, and overdose. These risks have not been well-quantified inside or outside of the VA, and beca…
Heidi Wendell Brown · MEDICAL COLLEGE OF WISCONSIN · 2024 · $771,630 — PROJECT SUMMARY/ABSTRACT Urinary incontinence affects more than 18 million U.S. women and is associated with healthcare costs in excess of $18 billion annually, with increasing prevalence as our population ages. Incontinence limits quality of life and increases the risk of depression, falls, and ins…
ALEXA A PRAGMAN · MINNEAPOLIS VA MEDICAL CENTER · 2024 — This is an application for a Merit Award to Dr. Alexa A. Pragman, M.D., Ph.D., a Staff Physician in Infectious Disease at the Minneapolis VA and an Assistant Professor at the University of Minnesota. Dr. Pragman’s current work on the chronic obstructive pulmonary disease lung microbiota is funded by…
ROBERT A. BONOMO · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · 2024 — Gram-negative pathogens producing metallo-β-lactamases, MBLs, are a significant threat to our public health as treatment options against bacteria possessing these resistance determinants are extremely limited. In general, MBLs are the most worrisome carbapenemases, inactivating “last resort” β-lacta…
Matthew J Yousefzadeh · MAYO CLINIC ROCHESTER · 2024 · $295,223 — Title: Inves�ga�ng the Impact of Novel Senescent Microglia in Alzheimer's Disease Pathology Abstract: Alzheimer's Disease (AD) is a debilita�ng neurodegenera�ve disorder with a cri�cal need for improved therapeu�c strategies. One controversial component of AD progression is the role of microglia, th…
BHARAT GAWANDE · APTUS BIOSCIENCES LLC · 2024 · $501,200 — Rapid affordable aptamer-based diagnostic test for Hepatitis C virus Aptus Biosciences, LLC Bharat Gawande Summary Hepatitis C virus (HCV) is a global public health crisis, and an estimated 58 million people worldwide and 2 million people in the United States live with chronic HCV infection and ar…
jack ogutu · MILLERSVILLE UNIVERSITY · 2024 · $47,950 — SUMMARY OF TRANING PROPOSAL Purpose and Program Rationale: Millersville University (MU) is one of 14 universities in the Pennsylvania State System of Higher Education. Millersville University offers an undergraduate, ABET-Accredited, degree program in Occupational Safety & Environmental Health (OSEH…
Tamara Sonia Bodnar · BROCK UNIVERSITY · 2024 · $242,144 — 7. Project Summary/Abstract Studies in both animal models and human cohorts have demonstrated broad impacts of prenatal alcohol exposure (PAE) on immune function. We showed, for the first time that PAE results in a more severe and prolonged course of inflammation in response to immune challenge in …
Catherine Anne Marcinkiewcz · UNIVERSITY OF FLORIDA · 2024 · $132,737 — Project Summary / Abstract Alcohol use disorders (AUDs) are associated with neurodegeneration and cognitive dysfunction, but the impact of alcohol use on Alzheimer's disease and related dementias (ADRD) is unknown. Our work suggests that chronic alcohol can alter the activity of serotonin (5-HT) neu…
Xinzhong Dong · JOHNS HOPKINS UNIVERSITY · 2024 · $582,414 — Project Summary The goal of our research is to understand the cellular and molecular mechanisms of chronic itch, a disease that interferes with normal daily activity and can have serious clinical consequences. Many pathological conditions can lead to chronic itch such as localized skin diseases or m…
Kirby M. Sherman · TEXAS A&M UNIVERSITY · 2024 · $40,194 — Project Summary/Abstract Down Syndrome (DS) is a common birth defect caused by trisomy of human chromosome 21 (Hsa21). DS leads to a vast array of clinical abnormalities affecting most systems of the body, including delayed wound healing, and an increased risk of long bone and vertebral fractures. P…
DAVID W. OSLIN · PHILADELPHIA VA MEDICAL CENTER · 2024 — Background: In the last several years, commercial pharmacogenetic (PGx) testing for psychotropic medications has become widespread as a means of implementing “precision medicine”, with some insurers electing to cover the cost of testing. These developments have put increasing pressure on the Veteran…
OWEN T. CARMICHAEL · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · 2024 · $719,854 — Abstract Alzheimer's Disease is steadily growing in prevelance, with a devastating public health impact. The prevelance of Alzheimer's Disease is higher in African Americans compared to white Americans, thereby constituting a health disparity. Interventions that prevent Alzheimer's Disease or change…
James Thrasher · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · 2024 · $328,501 — PROJECT SUMMARY: Tobacco product labeling is a critical public health policy, and most countries around the world require health warning labels (HWLs) on cigarette pack exteriors. One labeling option is cigarette package inserts – small printed leaflets inside of cigarette packs. For over a century…
NIGEL W BUNNETT · NEW YORK UNIVERSITY · 2024 · $795,324 — PROJECT SUMMARY/ABSTRACT Pharmacologic therapy for common forms of chronic pain is ineffective and plagued with side effects. Our long- term goal is to reveal mechanisms of pain/nociceptive signaling and define drug targets. G protein-coupled receptors (GPCRs) control most patho-physiological proces…