Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Christoforos Thomas · METHODIST HOSPITAL RESEARCH INSTITUTE · 2024 · $350,960 — Abstract Inflammatory breast cancer (IBC) is the most lethal form of breast cancer with median survival of about 4 years compared with more than 10 years for other forms of breast cancer. Poor prognosis is associated with the high propensity of these tumors to develop distant metastases. Despite a h…
Daniel Bryce Landi · DUKE UNIVERSITY · 2024 · $336,734 — Abstract Brain cancer is the most common cause of cancer death in patients age 0-19. Diffuse intrinsic pontine glioma (DIPG) has a median overall survival (OS) of approximately 8 months. High grade glioma (HGG) is similarly devastating, with a median OS of 16 months, and recurrent medulloblastoma (…
Howard H Chang · EMORY UNIVERSITY · 2024 · $522,400 — PROJECT SUMMARY/ABSTRACT Recent studies suggest high ambient temperatures increase the risk of preterm birth (<37 completed weeks of gestation), a leading cause of infant mortality and long-term neurological disabilities. Infants born early term (37-38 weeks) also have more morbidity compared to ful…
Steven A John · UNIVERSITY OF MINNESOTA · 2024 · $513,542 — Biomedical HIV prevention has extended beyond pill-based strategies to now include long-acting injectable HIV pre-exposure prophylaxis (LAI-PrEP) dosing regimens, yet implementation of LAI-PrEP is suboptimal to date. LAI-PrEP has unique implications for clinical practice that will not easily fit wit…
Kira Delmore · COLUMBIA UNIV NEW YORK MORNINGSIDE · 2024 · $398,406 — PROJECT SUMMARY The overall objective of research being pursued in the Delmore lab is to understand the genetics of behavior and speciation. Behavioral traits are tightly linked to fitness, human health, and disease but knowledge of their genetic basis is limited and has been hindered by several cha…
Susan Searles Nielsen · WASHINGTON UNIVERSITY · 2024 · $299,928 — Amyotrophic lateral sclerosis (ALS) is a rapidly fatal progressive neurological disorder characterized by the degeneration of motor neurons in the brain and spinal cord. Environmental exposures likely play an important role in ALS pathogenesis. However, due to difficulty recruiting large, representa…
Lisa Wooldridge · UNIVERSITY OF PENNSYLVANIA · 2024 · $48,974 — Project Summary/Abstract Opioid Use Disorder remains a dire public health problem, but opioid agonists such as fentanyl remain a first- line therapy for several pain conditions. As in recreational use settings, prolonged use of opioid agonists in pain management can produce physical dependence and a…
Andrew Ben Stergachis · UNIVERSITY OF WASHINGTON · 2024 · $388,750 — PROJECT SUMMARY/ABSTRACT Genetic testing is rapidly emerging as a cornerstone of medicine, enabling targeted therapies for patients with both common and rare disorders, and empowering patients, families and communities with knowledge about their condition. However, despite significant advances over …
P. MICHAEL HO · KAISER FOUNDATION RESEARCH INSTITUTE · 2024 · $1,137,968 — PROJECT SUMMARY/ABSTRACT Our goal is to improve control of cardiovascular (CV) disease risk factors using a multilevel intervention leveraging cellphone-based text messages integrated within health systems to improve control of American Heart Association’s Life’s Simple 7 (LS7) lifestyle factors (bl…
DAVID E. CONROY · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $474,828 — Project Summary Kidney stones affect an estimated 8.8% of American adults and direct medical costs exceed $10 billion annually. Five-year recurrence rates for stones have been as high as 40% and a standard guideline for prevention is to increase fluid intake enough to produce > 2.5 L of urine daily.…
Srinivasa Subramaniam · FLORIDA ATLANTIC UNIVERSITY · 2024 · $119,008 — The polyglutamine expansion in the huntingtin (mHTT) causes HD. Before HD onset, striatal atrophy occurs, with subsequent loss of cortico-striatal white matter (WM) connections in layer V. As HD progresses, it affects other parts of the brain and the peripheral tissues. The mechanisms underlying the…
Tian Hong · UNIVERSITY OF TEXAS DALLAS · 2024 · $389,998 — PROJECT SUMMARY Recent advances of experimental techniques allow quantitative and systems‐wide measurements of non‐ genetic heterogeneity of mammalian cells, which serves as a crucial factor for stem cell dynamics and differentiation potentials, as well as drug resistance of cancer cells. However, i…
Eduardo Gotuzzo · UNIVERSIDAD PERUANA CAYETANO HEREDIA · 2024 · $749,874 — Project Summary/Abstract Acute febrile illness (AFI) is an important cause of morbidity and productivity loss in Latin America. Despite efforts for surveillance and advancements in diagnostic capacity, the etiology of AFI is still unknown in over 50% of cases. Our Project of Febrile Illness Surveill…
Xiao Tan · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $169,560 — Inflammatory bowel disease (IBD) affects over 1.2 million patients in the United States and causes significant morbidity and healthcare expenditures. Studies have associated the development of IBD with changes in the human gut microbiome, which together with genetic and environmental factors alter i…
JOHN M HAWDON · GEORGE WASHINGTON UNIVERSITY · 2024 · $201,652 — Abstract: Parasitic nematode (PN) infections remain a major threat to human health globally. More than 1.5 billion people are infected with PNs, with children, pregnant women, and the elderly especially susceptible to morbidity from nematode infection. Control strategies are restricted to periodic d…
Sanjeev Noel · JOHNS HOPKINS UNIVERSITY · 2024 · $481,466 — ABSTRACT/PROJECT SUMMARY Acute kidney injury (AKI) occurs at a high rate in both native kidneys and allografts and has no specific therapy available. Prior studies have established T cell activation and trafficking as an important mechanism that modulate ischemia reperfusion (IR) and nephrotoxic AKI…
Derek P Claxton · VANDERBILT UNIVERSITY · 2024 · $338,889 — Project Summary This proposal requests support for investigating the structure and enzymology of glucose-6-phosphatase catalytic subunit 1 (G6PC1), an integral membrane protein of the phosphatidic acid phosphatase type 2 (PAP2) superfamily expressed in the ER that catalyzes glucose production in th…
Sterling C Johnson · UNIVERSITY OF WISCONSIN-MADISON · 2024 · $2,617,616 — PROJECT SUMMARY / ABSTRACT This project conducts longitudinal Alzheimer’s Disease (AD) biomarker imaging on participants in the Wisconsin Registry for Alzheimer’s Prevention, a midlife observational cohort that is risk-enriched for AD due to parental history of AD dementia. We have been conducting l…
Cindy Menjivar · UNIVERSITY OF KANSAS MEDICAL CENTER · 2024 · $37,460 — PROJECT SUMMARY/ABSTRACT Bacteria require fatty acids for a variety of biological functions, including the construction of phospholipids. Staphylococcus aureus, like other bacteria, synthesize fatty acids using a fatty acid biosynthesis pathway referred to as FASII, but can also scavenge fatty acids…
SHEILA M SCHINDLER-IVENS · MARQUETTE UNIVERSITY · 2024 · $193,125 — Project Summary The goal of lower limb rehabilitation after stroke is recovery of independent walking at home and in the community. Few stroke survivors achieve this goal. Suboptimal outcomes are due to the serious and intransigent nature of movement impairments caused by stroke and the scarcity of …