Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Maria Mori Brooks · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $732,050 — As patients with sickle cell disease (SCD) live to adulthood, the chronic impact of sustained hemolytic anemia and episodic vaso-occlusive events take their toll, with the progressive development of cardiopulmonary organ dysfunction. This culminates in the development of pulmonary hypertension, left…
BERT Brandon BOYER · OREGON HEALTH & SCIENCE UNIVERSITY · 2024 · $748,455 — Project Summary/Abstract Heart disease is the leading cause of death for Alaska Native men and the second leading cause of death (after cancer) among women and Alaska Native people overall. The overarching goal of the proposed multilevel, multicomponent intervention, Diet and Active Lifestyle - Yuuy…
Rajmohan Bhandari · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $1,608,204 — Project Summary To advance the development of next-generation personalized therapies for long-term seizure freedom, we urgently need technologies that improve seizure diagnostics while reducing risks associated with invasive neurosurgical procedures. Among the more than 1,000,000 Americans with unco…
Georgene W Hergenroeder · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 2024 · $1,401,149 — Project Summary/Abstract Debilitating neuropathic pain occurs in 40-70% of people who suffer from spinal cord injury (SCI). It is unknown why, with similar injuries, one person will develop neuropathic pain while another will not. There are no distinguishing characteristics to identify who will deve…
Haluk Beyenal · MAYO CLINIC ROCHESTER · 2024 · $424,176 — PROJECT SUMMARY Biofilm bacteria cause two-thirds of infections in modern clinical practice, including wound and device- related infections. Host defenses and most available antibiotics are inactive against biofilms, rendering the infections they cause challenging to treat. Given the failure of ant…
Sushanta K. Banerjee · KANSAS CITY VA MEDICAL CENTER · 2024 — The Pancreatic ductal adenocarcinoma (PDAC), mostly a mutant K-Ras driven, in which hypoxia triggers acidification of extracellular matrix, epithelial-to-mesenchymal transition (EMT)/cancer stemness (CSCs), metastasis, desmoplasia, and chemoresistance. These pathological changes grim the prognosis o…
Xiaosi Han · BIRMINGHAM VA MEDICAL CENTER · 2024 — Project Summary/Abstract Gliomas are incurable and are the number two cause for tumor mortality in adult under 40 years old. Monoallelic mutations of IDH1 and IDH2, which encode isocitrate dehydrogenases (IDH) that convert isocitrate into α-ketoglutarate (αKG), have been detected in 80% of low grade…
Suzanne Bertisch · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $590,643 — ABSTRACT Insomnia, present among 15-25% of low-income adults and other overlapping socioeconomically disadvantaged groups such as racial/ethnic minorities, is frequently undertreated, impairs quality of life, and is associated with increased risk for depression, cardiovascular disease, and premature…
Shuk-Mei Ho · CENTRAL ARKANSAS VETERANS HLTHCARE SYS · 2024 — According to the United States (US) Census Bureau, the number of veterans in the US in 2018 was around 19.9 million. Nine out of 10 were males, and 33% were between 50-69 years old, an age group that is at the highest risk for prostate cancer (PCa). The VA Central Cancer Registry consistently shows …
Saumya Reddy Bollam · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $38,598 — Project Summary Recent investigations have revealed that oncogenic mutations are not sufficient for initial stages of tumorigenesis and that the microenvironment plays a significant role in promoting neoplastic growth of a tumor. This microenvironment surrounding a mutated cell can be influenced by …
Dan Jane-Wit · VA CONNECTICUT HEALTHCARE SYSTEM · 2024 — Ischemia reperfusion injury (IRI) is a pathological process affecting solid organ allografts and occurs when a transplanted organ subjected to prolonged disruption of blood flow undergoes tissue damage following surgical implantation. IRI frequently occurs among deceased donors and predisposes to ch…
AJAY NMN RANA · JESSE BROWN VA MEDICAL CENTER · 2024 — Summary/Abstract: Pancreatic Ductal Adenocarcinoma (PDAC) remains remarkably lethal with a 5-year survival rate of less than 9%. Due to its widespread resistance to conventional therapy, PDAC is expected to be the second most common cause of cancer-related death in the United States by 2030. Oncogen…
William Maurice Shafer · VETERANS HEALTH ADMINISTRATION · 2024 — Project Summary In this competitive renewal of my Senior Research Career Scientist (SRCS) award I will continue my research, service, and teaching/mentoring efforts that have been the areas of concentration during past funding periods. My research program focuses on antibiotic resistance as it is no…
Sailesh Harwani · IOWA CITY VA MEDICAL CENTER · 2024 — Nearly half of US adults have hypertension. Hypertension is also highly prevalent in the VA Health System. Traditionally, hypertension has been thought to be a function of abnormalities in the renal, vascular, and nervous systems. In recent years, clinical and basic science data clearly demonstrate …
MARTIN J GALLAGHER · VETERANS HEALTH ADMINISTRATION · 2024 — During the recent conflicts in Iraq and Afghanistan, thousands of service personnel suffered mild traumatic brain injuries (mTBIs), those that do not cause gross anatomical damage or hemorrhage and produce only brief periods of altered awareness. Although these brain injuries are classified as “mild…
RAJU C REDDY · VETERANS HEALTH ADMINISTRATION · 2024 — Chronic obstructive pulmonary disease (COPD), usually caused by cigarette smoking, is rising in prevalence and is predicted to become the leading cause of death worldwide by mid-century. Available treatments provide only short-term benefit, and fail to stop COPD’s inexorable progression. Even smokin…
GRACE L GUO · VA NEW JERSEY HEALTH CARE SYSTEM · 2024 — PROJECT SUMMARY The prevalence of cirrhosis and decompensated liver disease has doubled, whereas the prevalence of hepatocellular carcinoma (HCC) has increased 10-fold in the veteran population. Worldwide, HCC has emerged as a major cause of cancer-related death. There is an urgent need to further …
Adolfo Ariel Jaitovich · ALBANY MEDICAL COLLEGE · 2024 · $544,301 — Project Summary: Patients with chronic obstructive pulmonary disease (COPD)/pulmonary emphysema often develop locomotor muscle dysfunction, which is associated with worse clinical outcomes including higher mortality. Retention of CO2 in the blood, or hypercapnia, is also frequent in these patients a…
Cheri Alicia Levinson · UNIVERSITY OF LOUISVILLE · 2024 · $234,750 — PROJECT SUMMARY/ABSTRACT Eating disorders (EDs) are serious mental illness, with the second highest mortality rate of any psychiatric disorder and carry high societal, personal, and economic costs. Treatment response for EDs are suboptimal, with only 50% of adults responding to evidence based treatm…
KENNETH L ROCK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2024 · $593,865 — Abstract The immune system has evolved mechanisms to recognize cell injury and in response stimulate sterile inflammation. This response contributes in important ways to both heath and disease. In this process, dying cells release Damage Associated Cell Patterns (DAMPs) that are detected by receptor…