NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Tao Zhou · PENNSYLVANIA STATE UNIVERSITY, THE · 2024 · $386,592 — Project Summary The objective of this proposal is to develop a soft and stretchable tissue-like bioadhesive electronic device for the treatment of resistant hypertension. Hypertension is a major burden on healthcare systems and an important contributor to global morbidity and mortality. Although a n…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Anthony T Vella · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · 2024 · $566,723 — Project Summary Type 2 diabetes mellitus (T2DM) is a primary cause of the marked increase of ASCVD, accounting for over 30% of symptomatic cases. Accordingly, the ASCVD risk in T2DM patients is 2-4 fold more than in the non-T2DM population. The concomitant increase of T2DM and ASCVD in the US prompt…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Christos Papadelis · COOK CHILDREN'S MEDICAL CENTER · 2024 · $454,820 — Project Summary For children with drug-resistant epilepsy (DRE), resective surgery is the most effective treatment to achieve seizure-freedom. Its success depends on the resection of the epileptogenic zone (EZ). The gold standard to estimate the EZ is by recording seizures with intracranial EEG (iEE…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Timothy L. Lash · EMORY UNIVERSITY · 2024 · $653,500 — PROJECT SUMMARY Surveillance for cancer incidence and mortality is crucial to cancer control and cancer research. Cancer registries are the basis for allocating public health resources as well as designing and assessing interventions to control cancer morbidity and mortality through prevention, scr…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Nicolaas E Deutz · TEXAS A&M UNIVERSITY · 2024 · $457,498 — ABSTRACT Sepsis is a potentially life-threatening complication of an infection in critically ill patients and is characterized by severe tissue breakdown, leading to long-term muscle weakness, fatigue, and reduced physical activity. Early and targeted nutritional intervention is critical in enhancin…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Aadel Chaudhuri · WASHINGTON UNIVERSITY · 2024 · $596,475 — PROJECT SUMMARY The deadliest form of advanced-stage prostate cancer is treatment-resistant metastatic castration- resistant prostate cancer (mCRPC), which occurs in ~35% of patients after exposure to androgen receptor (AR)-directed therapies such as Abiraterone and Enzalutamide, resulting in a dism…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Sean Bjorn Ostlund · UNIVERSITY OF CALIFORNIA-IRVINE · 2024 · $635,357 — PROJECT SUMMARY Situational cues that signal reward availability can exert a powerful invigorating influence over reward-seeking behavior. However, this impulse to seek out reward is not always adaptive. To conserve time and effort, cue- motivated reward seeking is regulated by homeostatic and cogni…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
M. Kristen Demoruelle · UNIVERSITY OF COLORADO DENVER · 2024 · $361,090 — PROJECT SUMMARY/ABSTRACT Formation of anti-citrullinated protein antibodies (ACPA) is an early step in the development of rheumatoid arthritis (RA). Serum ACPA are highly predictive of developing RA and can directly promote joint damage. Yet, there remains a major gap in our understanding of ACPA de…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
CHENGCHENG ZHANG · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $551,973 — Abstract T cell-centered immunotherapies, including PD-1/PD-L1 blockade, have been successful in treating some types of cancers but not others. The roles of other immune cells including immunosuppressive monocytic cells in tumor development and treatment are not well defined. A better understanding …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
FREDERICK M HUGHSON · PRINCETON UNIVERSITY · 2024 · $375,270 — PROJECT SUMMARY / ABSTRACT The traffic patterns established by transport vesicles are of fundamental importance for protein localization, modification, and function within eukaryotic cells. Cargo transported by these vesicles is delivered through the fusion of the vesicle with the membrane of a targ…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
John D Mountz · BIRMINGHAM VA MEDICAL CENTER · 2024 — The overall goal of this project is to determine if the IKAROS transcription factor regulates a program that maintains IL-4 receptor (IL-4R)-mediated B-cell quiescence to ribonuclear protein (RNP) autoantigens (autoAgs). We propose that B cell activation through the type I interferon (IFN)/TLR7 acti…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Jeffrey J. Ishizuka · YALE UNIVERSITY · 2024 · $212,878 — PROJECT SUMMARY: Immune checkpoint inhibition of the PD-1/PD-L1 pathway has demonstrated dramatic and durable clinical benefit for patients in many cancer types and is increasingly being incorporated into standard of care treatment regimens. However, in most tumor types, this strategy is effective …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Omar Beleh · UNIVERSITY OF WISCONSIN-MADISON · 2024 · $74,284 — Project Summary The overarching theme of this proposal is to apply robust and reliable reaction mechanisms to improve the efficiency of forming C–C bonds adjacent to alcohol or amine functionality. Among the most common strategies to these products is the addition of a Grignard reagent (or other car…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Eduardo Groisman · YALE UNIVERSITY · 2024 · $521,943 — PROJECT SUMMARY All pathogens require proteins to cause disease. Protein abundance reflects a delicate balance between synthesis and degradation critical for pathogenesis and antibiotic tolerance. Protein degradation must be tightly controlled because its effects are irreversible. We aim to determin…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Derek James Smith · UNIVERSITY OF CAMBRIDGE · 2024 · $513,236 — PROJECT SUMMARY Seasonal influenza virus vaccines have to be reformulated most years primarily due to immune escape caused by mutations in the surface hemagglutinin (HA) protein. The genetic variation in HA only occasionally causes change in antigenic phenotype and consequent immune escape. For exte…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
CHRISTINE M ALBERT · CEDARS-SINAI MEDICAL CENTER · 2024 · $1,491,021 — Sudden and/or arrhythmic death (SAD), which typically results from lethal ventricular arrhythmias (ventricular tachycardia and ventricular fibrillation, VT/VF) in the setting of coronary heart disease (CHD), afflicts an estimated 310,000 persons annually in the United States. Reductions in SAD have …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
MARGARET A. ROGERS · AMERICAN SPEECH-LANGUAGE-HEARING ASSN · 2024 · $39,900 — The Research Symposium in Communication Sciences and Disorders supports a full day of presentations by leading scientists in areas that are having transformational effects in the communication sciences and disorders (CSD) discipline. The Research Symposium is held at the annual Convention of the Ame…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Collin Jeffrey Popp · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $148,540 — Project Summary/Abstract Despite great strides in achieving short-term weight loss success, long-term weight loss maintenance (WLM) remains a challenge. Time-restricted eating (TRE), a form of intermittent fasting, is an untested bio-behavioral strategy for WLM. The goal of this Pathway to Independe…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Susan Anne Tuddenham · JOHNS HOPKINS UNIVERSITY · 2024 · $203,892 — Bacterial vaginosis (BV), which is characterized by a dysbiotic vaginal microbiota low in Lactobacillus species, affects nearly 30% of U.S. women; the majority (55%) are asymptomatic (aBV). Guidelines currently recommend testing and treatment only for symptomatic BV (sBV). BV (a composite variable w…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
CHRISTOPHER J KRISTICH · MEDICAL COLLEGE OF WISCONSIN · 2024 · $476,642 — PROJECT SUMMARY The continued and inevitable emergence of antibiotic resistance demands a vigorous and sustained effort to identify fundamentally new targets and strategies for innovative antimicrobial therapeutics. Antibiotic-resistant enterococci are major causes of hospital-acquired infections. E…