Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
MIN ZHOU · OHIO STATE UNIVERSITY · 2024 · $346,725 — Astrocytes are key players in regulating neuronal excitability and neurotransmission. We have recently shown that astrocytes participate in brain functions thrugh “team-work”. Specifically, a strong gap junction coupling, astrocytes achieve a state of syncytial isopotentiality across the brain that …
Brian Elbel · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $786,886 — PROJECT SUMMARY/ABSTRACT This project will examine the impact of taxes on sugar sweetened beverages (SSBs) utilizing detailed sales data from one of the largest fast food retailers in the U.S. Taxes on SSBs are one of the most promising solutions to reduce population-wide consumption of these unhea…
Charlie M Wray · VETERANS AFFAIRS MED CTR SAN FRANCISCO · 2024 — Background: Improving access to care is a high priority within the VA. While improvements to access have been made in recent years, gaps and inefficiencies still exist, particularly around missed clinic visits, or `no- shows'. The VA reports that approximately 15-18% of scheduled outpatient primary …
Eric Chien-Wei Liao · CHILDREN'S HOSP OF PHILADELPHIA · 2024 · $659,562 — Technical abstract Genetic study of orofacial clefts (OFC) is foundational to genetics of congenital structural birth defects. Most OFC cases are non-syndromic and involve complex genetic mechanisms that are yet to be fully elucidated. Currently, genetic diagnosis for cleft anomalies is hampered by …
Michael Moshe Yartsev · UNIVERSITY OF CALIFORNIA BERKELEY · 2024 · $409,772 — PROJECT SUMMARY Social relationships develop between individuals with a social network. Difficulties in mediating social relationships with other individuals is strongly associated with severe mental disorders ranging from depression, chronic stress, autism and other. Thus, understanding the neural …
Anne Christine Eichmann · YALE UNIVERSITY · 2024 · $548,579 — The objectives of the proposal are to determine, for the first time, how developing meningeal lymphatic vessels (MLVs) impact neuroimmune communication in early postnatal life, and if MLV- dependent neuroimmune communication can be harnessed by VEGF-C signaling in young mice at steady state and in a…
Shira Hannah Fischer · RAND CORPORATION · 2024 · $811,942 — SUMMARY/ABSTRACT During a public health emergency such as the COVID-19 pandemic, rapid dissemination of information to clinicians about emerging innovations is critical to ensuring the best outcomes for patients. However, little is known about how clinicians obtain information about innovations make…
JOHN David HERRINGTON · CHILDREN'S HOSP OF PHILADELPHIA · 2024 · $832,008 — ABSTRACT Difficulties with emotion expression and social behavior characterize multiple psychiatric conditions and negatively impact child development. However, existing measurement tools for indexing social-emotional function are imprecise and subjective, or require specialized training that is cos…
Gira Bhabha · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $134,588 — Project Summary/Abstract Microsporidia are unicellular, fungal parasites with a wide host-range, from insects to humans. They are emerging pathogens, classified as NIAID Category B opportunistic pathogens, and cause microsporidiosis in immunocompromised patients. To gain entry into a target cel…
George A. O'Toole · DARTMOUTH COLLEGE · 2024 · $387,332 — Abstract: We study the molecular mechanisms and signaling, from environmental input to physiological output, that control bacterial biofilm formation, a key bacterial lifestyle linked to host-microbe interactions and infectious disease. In particular, the capability of bacteria to sense and respond …
PRAVEEN BALLABH · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2024 · $524,745 — Abstract Intraventricular hemorrhage (IVH) remains a major neurological complication of prematurity that results in cerebral palsy, hydrocephalus, and cognitive deficits. No effective therapy exists to prevent these disorders in infants with IVH. IVH triggers inflammation in the periventricular germ…
Alison Huang · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $352,477 — PROJECT SUMMARY The goal of this Stimulating Access to Research in Residency (StARR) proposal is to recruit, train, and mentor a multidisciplinary group of exceptional UCSF postgraduate resident investigators in acquiring rigorous clinical and translational research skills, conducting high-impact an…
Priya Shirish Shah · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $548,496 — PROJECT SUMMARY/ABSTRACT Viruses that infect the developing brain, including Zika virus (ZIKV), cytomegalovirus, and rubella virus cause major birth defects. Microcephaly is one such birth defect, in which head and brain size are severely reduced, and is often accompanied by intellectual disability.…
Deniz Nesli Dolcen · STANFORD UNIVERSITY · 2024 · $97,265 — PROJECT SUMMARY My lab discovered that NNMT is a direct GR transcriptional target gene in TNBC. I then observed relatively high NNMT expression in several aggressive patient-derived TNBC cell lines. NNMT consumes the universal methyl donor S-adenosyl methionine (SAM) for methylation of nicotinamide…
Charlotte Eielson Ariyan · SLOAN-KETTERING INST CAN RESEARCH · 2024 · $348,734 — Project Summary / Abstract The Memorial Sloan Kettering Cancer Center (MSK) Summer Research Fellowship Program is a cancer education program that enables 30 first- and second-year U.S. medical students to participate in laboratory and clinical research under the mentorship of MSK’s clinical faculty.…
Floor J. Backes · OHIO STATE UNIVERSITY · 2024 · $132,015 — Project Summary/Abstract Gynecologic Cancer remains an underfunded area of research with funding to lethality scores significantly lower than other cancer sites. Endometrial cancer, the most common gynecologic cancer, is one of the few cancers that has seen an increase in incidence and mortality ove…
Daniel Harrison Craighead · UNIVERSITY OF COLORADO · 2024 · $117,375 — PROJECT SUMMARY High blood pressure (BP), particularly systolic BP (SBP), is the major modifiable risk factor for cardiovascular diseases (CVD) and related conditions such as chronic kidney disease and cognitive decline/dementia. In fact, ~60% of adults in the United States have above-normal SBP (≥1…
Katherine Louise Bottenhorn · UNIVERSITY OF SOUTHERN CALIFORNIA · 2024 · $124,169 — PROJECT SUMMARY This proposal aims to address the BRAIN Initiative goals of developing and applying technologies for innovative study of the relationships between biological processes, neural structure, and brain function, to further our understanding of how sex hormones (e.g., estradiol, testostero…
KATALIN SUSZTAK · UNIVERSITY OF PENNSYLVANIA · 2024 · $465,499 — The estimated heritability of kidney disease is around 50%. Common variants, that are almost always non-coding, account for much of the predisposition to prevalent, later-onset kidney diseases such as diabetic and hypertensive kidney disease (DKD, HKD). Genome wide association studies (GWAS) have pr…
Andrew Camilli · TUFTS UNIVERSITY BOSTON · 2024 · $465,324 — PROJECT SUMMARY Bacteriophages (phages) are viruses that specifically infect bacteria. Phages have been shown to play important roles in the life cycle of many bacterial pathogens, particularly water-borne pathogens that cause gastrointestinal tract infections. For example, the lysogenic phages, whi…