Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Jennifer Zieba · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $390,000 — Project Summary Osteogenesis imperfecta (OI) is a genetically heterogenous disorder characterized by increased bone fragility leading to fractures and primarily results from defects in the structure and/or the amount of secreted type I collagen. While bone fragility is the primary cause of morbidity…
Hui-Kuan Lin · DUKE UNIVERSITY · 2024 · $491,137 — Non-small cell lung cancer (NSCLC) accounts for around 85% of all lung cancer. The 5- year survival rate is about 14% for stage IIIA NSCLC, while it is about 5% for stage IIIB. However, once NSCLC has reached to the stage IV and metastasized to different places, it is very difficult to treat. The 5-…
Christopher L King · CASE WESTERN RESERVE UNIVERSITY · 2024 · $697,088 — The goal of our proposal is to develop new approaches for the prevention and treatment of human malaria caused by the parasite Plasmodium vivax (P. vivax). This type of malaria, known as vivax malaria, is the most widely distributed type of malaria with 3.3 billion people at risk and at least 15 mil…
Noah Sullivan Butler · UNIVERSITY OF IOWA · 2024 · $466,500 — PROJECT SUMMARY Plasmodium infections and the disease malaria remain global health emergencies. Plasmodium parasites replicate within and cause the destruction of host red blood cells, which triggers inflammation and causes the symptoms of malarial disease. Parasite-specific antibody responses that …
Graca Duarte Almeida-Porada · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2024 · $383,921 — PROJECT SUMMARY Gene therapy (GT) clinical trials using AAV vectors are poised to fulfill the promise of a safe, affordable, lifelong correction of bleeding disorders following a single treatment. Still, clinical trials using AAV vectors to treat hemophilia A (HA) in adults have underscored the hurd…
BRIAN M WARD · UNIVERSITY OF ROCHESTER · 2024 · $385,000 — Poxviruses are a large family of DNA viruses with several members capable of infecting and causing disease in humans. Whereas the most notorious member, variola virus, is the causative agent of smallpox and was eradicated from natural infection, there are still concerns about a clandestine release d…
DARREN A NATALE · GEORGETOWN UNIVERSITY · 2024 · $446,214 — PROJECT SUMMARY Immune epitopes--the portions of an antigen that are recognized by antibodies and T-cell receptors--are key to understanding healthy and abnormal immune responses. The Immune Epitope Database (IEDB) is a freely available resource funded by the National Institute of Allergy and Infect…
Patrick Sweeney · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · 2024 · $239,039 — Proposal Summary: The increasing rates of obesity and associated metabolic syndrome pose a major public health concern. Although behavioral (diet and/or exercise), surgical, and pharmacological modalities exist for weight loss, many individuals are unable to maintain this weight loss due to behavior…
Yutao Liu · AUGUSTA UNIVERSITY · 2024 · $383,430 — Abstract The goal of this application is to determine the role of estrogen and its receptors - estrogen receptor 1 (ESR1) and G protein coupled estrogen receptor (GPER1) – in regulating intraocular pressure (IOP) through trabecular meshwork (TM) and Schlemm's canal (SC) endothelial cells. IOP is the…
SHEILA COLLINS · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $808,810 — Abstract Excess fat accumulation and deposition of ectopic lipid in visceral adipose tissue (VAT), the liver and skeletal muscles contribute substantially to the high risk for cardiometabolic disease in persons with HIV (PWH) on antiretroviral therapy (ART). While the potential for weight gain durin…
Russell T Hepple · UNIVERSITY OF FLORIDA · 2024 · $499,863 — PROJECT SUMMARY/ABSTRACT Physical frailty (hereafter simplified to “frailty”) refers to a clinical state associated with an individual’s increased risk of dependence or mortality when exposed to a stressor and has emerged as a major predictor of poor health outcomes in the elderly. Unfortunately, th…
THEODORE P ZANTO · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $524,623 — Abstract The overall goal of this project is to collect pilot feasibility and early efficacy data showing improvements in cognition and wellbeing in adults with mild cognitive impairment (MCI) through a combination treatment of non-invasive brain stimulation (transcranial alternating current stimula…
Steven Bassnett · WASHINGTON UNIVERSITY · 2024 · $477,830 — Project Summary The fibers of the ciliary zonule suspend the lens on the optical axis and transmit the forces that flatten it during disaccommodation. Mutations in genes encoding zonular proteins underlie syndromic and non-syndromic conditions that affect the eye profoundly. Common ocular phenotypes…
William James Hall · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $386,605 — Project Summary/Abstract This R01 application responds to the National Institutes of Health Notice of Special Interest in Research on the Health of Sexual and Gender Minority (SGM) Populations (NOT-MD-19-001). Sexual minority youth (SMY) face a number of mental health disparities, including high rat…
Cristina Canavesi · LIGHTOPTECH CORPORATION · 2024 · $886,898 — The cornea, the outermost window of our visual system, is vulnerable to various types of infections and diseases. Corneal disease is one of the leading causes of visual deficiency and blindness, and is considered the second major cause of blindness in developing countries. There are nearly 5 million…
Toshimitsu Kawate · CORNELL UNIVERSITY · 2024 · $327,314 — ABSTRACT Pannexins comprise a unique family of heptameric large-pore channels that are emerging as novel targets for treating common, yet hard to cure diseases such as hypertension and chronic pain. Previous studies indicate that Panx1 is activated through stimulation of structurally unrelated recep…
Mark Bryan Headley · FRED HUTCHINSON CANCER CENTER · 2024 · $204,543 — PROJECT SUMMARY/ABSTRACT Premature birth is a leading cause of infant mortality in the United States, and lung immaturity in these babies is a major cause. As the organ of gas exchange, efficient lung function is critical for the survival of the newborn. At birth, premature lungs are in the saccular…
Craig Evan Pollack · JOHNS HOPKINS UNIVERSITY · 2024 · $1,515,196 — Project Summary An estimated 41% of adults in the US and one in five of children are estimated to have obesity; over 37 million Americans have diabetes and 96 million adults have prediabetes. Racial and socioeconomic disparities in obe- sity and diabetes prevalence are well-documented, widespread, a…
Heather Burrell Ward · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $185,544 — PROJECT SUMMARY Tobacco use is the top preventable cause of early mortality in schizophrenia, leading to a 20-year decreased life expectancy compared to the general population. Current smoking cessation treatments are derived from people without psychosis and are significantly less effective for peo…
Dominic David Frank · ROCKEFELLER UNIVERSITY · 2024 · $125,902 — Project Summary Impaired social communication is a major feature of common neurodevelopmental disorders like autism spectrum disorder. Nevertheless, cellular mechanisms underlying the development of affected brain networks remain uncertain, despite the potential to inspire novel diagnostics and phar…