Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Staci D Bilbo · DUKE UNIVERSITY · 2024 · $395,625 — The dopaminergic “reward” circuitry undergoes significant developmental plasticity during adolescence, including the refinement of dopamine D1 and D2 (D1/D2r) receptors within the nucleus accumbens (NAc). We have recently demonstrated in male rats that microglia – the primary immune cells of the CNS…
Jennifer Muszynski · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · 2024 · $680,899 — Abstract Worldwide, nearly 3 million children die each year from sepsis. Red blood cells (RBC) are transfused in ~50% of children with septic shock, with the intent to enhance oxygen delivery, help resolve shock, and prevent organ dysfunction. However, RBC transfusion has repeatedly been associated …
MICHAEL F MILES · VIRGINIA COMMONWEALTH UNIVERSITY · 2024 · $408,009 — This revised application proposes a new T32 Institutional National Research Service Award with five years of support to fund Cross-Species Multidisciplinary Training in Alcohol Research, comprising four pre-doctoral and two postdoctoral trainees. Virginia Commonwealth University (VCU) has a history …
Valerie G Press · UNIVERSITY OF CHICAGO · 2024 · $121,208 — PROJECT ABSTRACT Chronic Obstructive Pulmonary Disease (COPD) affects more than 16 million US adults, many of whom experience high rates of acute care revisits (emergency department and hospital) after initial COPD hospitalization. These frequent exacerbations, often due to transition of care (TOC) …
CHRISTOPHER P DUGGAN · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · 2024 · $602,533 — Project Summary The overall project goal is to investigate zinc supplementation in combination with standard antibiotic therapy as a simple, low-cost, and readily available intervention to improve survival and treatment outcomes for Tanzanian young infants hospitalized with ‘clinical severe infectio…
Gregg E. Trahey · DUKE UNIVERSITY · 2024 · $468,184 — Abstract Ultrasonic imaging is widely used to monitor fetal growth and development during the first and second trimester, and multiple studies document the resultant positive impacts on fetal and maternal outcomes. However, current methods fail to provide adequate visualization of key structures in …
XIAO-FAN WANG · DUKE UNIVERSITY · 2024 · $390,599 — This proposal's long-term objective is to provide a fundamental mechanistic understanding of the role of nucleus vs. mitochondria in the activation of the senescence program. Senescence is a central cellular defense mechanism that removes damaged cells to maintain tissue integrity and prevent tumori…
HONG YU · UNIVERSITY OF MASSACHUSETTS LOWELL · 2024 · $782,282 — Social and behavioral determinants of health and Alzheimer’s Disease: Cohort study of the US military veteran population Alzheimer’s Disease (AD) affects an estimated 5.8 million US adults. Veterans are particularly susceptible to AD due to demographic, clinical, and economic factors. Social determ…
SETH MICHAEL BLOOM · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $182,304 — Project Summary/Abstract The vaginal microbiome is associated with important health outcomes, including bacterial vaginosis (BV), preterm birth, HIV risk, and cervical cancer, but mechanisms for these associations are unclear and current microbiome-directed therapies have low efficacy. Metabolome al…
Raul Andino · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $848,303 — Project Summary Human enterovirus (HEV) infections primarily affect infant and adolescent populations, causing a wide range of clinical manifestations that commonly include respiratory illness and mucocutaneous lesions, or hand, foot and mouth disease. In some cases, the infection is life- threateni…
David H. Wagner · UNIVERSITY OF COLORADO DENVER · 2024 · $422,463 — Abstract: Controlling the autoimmune inflammation in type 1 diabetes (T1D) has proven difficult. Currently there are clinical trials to attempt controlling T1D that are having only marginal impact. Desired primary outcomes include increasing of C-peptide, as a marker for beta cell restoration, decre…
Kurt G Schilling · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $157,404 — Diffusion magnetic resonance imaging (MRI) enables the ability to probe both tissue microstructure and structural connectivity of the central nervous system. However, there are no validated methods to model and interrogate the pathways that connect the brain and spinal cord, which inhibits our abili…
Justin McNair Canada · VIRGINIA COMMONWEALTH UNIVERSITY · 2024 · $149,049 — PROJECT SUMMARY This K23 project will prepare the Principal Investigator, Justin M. Canada, PhD, to develop as an independent clinical/translational researcher who is expert in a novel form of cardiopulmonary exercise stress measurement – cardiovascular magnetic resonance imaging (MRI) – to identif…
Christopher A Ahern · UNIVERSITY OF IOWA · 2024 · $466,355 — Abstract Voltage-gated sodium channels (NaVs) maintain the electrical cadence in cardiac muscle tissues by selectively controlling the rapid inward passage of sodium. The NaV complex is comprised of a 260-kDa pore- forming α-subunit (encoded primarily by NaV1.5 in heart) that partners with β -subun…
FEI DU · MCLEAN HOSPITAL · 2024 · $844,822 — Project Summary Schizophrenia (SZ) is a devastating psychiatric disorder that brings heavy burden to health care systems. A large literature indicates that individuals with SZ show markers of early aging, such as faster decline in cognitive functioning, increased risk for dementia, and significantly…
Joseph M Martinez · BOSTON UNIVERSITY MEDICAL CAMPUS · 2024 · $82,180 — Project Summary The process of selecting an action, evaluating, and storing the outcome to inform future responses requires the basal ganglia (BG) and extended circuits such as the lateral habenula (LHb). Indeed, perturbed LHb activity is observed in multiple human neurological disorders where acti…
Martin Stengelin · MESO SCALE DIAGNOSTICS, LLC · 2024 · $435,526 — This industrial-academic collaboration seeks to analytically validate a highly specific and sensitive multiplexed immunoassay for glial fibrillary acid protein (GFAP) and tau in serum and/or plasma to improve treatment decisions for neonates with hypoxic-ischemic encephalopathy (HIE). HIE, which aff…
Andreas Schwingshackl · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $539,686 — PROJECT SUMMARY: Significance: Oxygen supplementation (hyperoxia; HO) is the most frequently applied therapy for hospitalized patients and the cornerstone of treatment for acute hypoxic respiratory failure (ARF). It is well known, however, that HO exposure can not only promote existing lung injury …
DAVID R BRIGSTOCK · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · 2024 · $409,839 — ABSTRACT The broad long term objective is to improve methods of disease treatment in the liver. Hepatic fibrosis is a major cause of morbidity and mortality that affects millions of people world-wide and is usually a feature of chronic liver disease such as that caused by excessive alcohol consumpti…
ROBERT H GILMAN · UNIVERSIDAD PERUANA CAYETANO HEREDIA · 2024 · $289,680 — Implementation Research in Infectious Diseases in Peru – GARCIA, Hector H. Training in Infectious Diseases in Peru – Time for Implementation Research PROJECT SUMMARY This renewal application proposes to apply the training experience built in Peru over the past 25 years with Fogarty support, and ta…