NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Lindsay Kennedy Admon · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $399,999 — PROJECT SUMMARY State Medicaid programs pay for nearly half of all births in the United States (U.S.), financing over 1.6 million births in 2019. Federal law requires states to provide pregnancy-related Medicaid coverage to low-income pregnant individuals through 60 days postpartum, after which 1 in…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Robert John Wong · PALO ALTO VETERANS INSTIT FOR RESEARCH · 2024 · $633,897 — Background: Implementing timely and consistent hepatocellular carcinoma (HCC) screening among cirrhosis patients improves early tumor detection, treatment options, and overall survival. Guideline- concordant HCC screening rates are suboptimal, particularly among ethnic minorities and non-English spe…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Pamela Fitch Weiss · CHILDREN'S HOSP OF PHILADELPHIA · 2024 · $377,034 — PROJECT SUMMARY Across the world, spondyloarthritis (SpA) is the most common form of juvenile arthritis, accounting for as many as one-third of all cases. Since the introduction of biologic disease modifying agents such as tumor necrosis factor inhibitors (TNFi), inactive disease is a realistic goal…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
PETER John DONOVAN · UNIVERSITY OF CALIFORNIA-IRVINE · 2024 · $266,678 — PROJECT SUMMARY In the 21st century it has become clear that many of the major problems facing humanity will need to be addressed by biologists carrying out biomedical research. In order for the US biomedical research community to succeed in combating the major challenges facing our world, scientist…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Hallie Christine Prescott · VETERANS HEALTH ADMINISTRATION · 2024 — Background. Sepsis—life-threatening organ dysfunction triggered by infection—hospitalizes more than 25,000 Veterans each year, making it the 2nd most common reason for hospitalization in the VA. While most Veterans survive the acute episode, many suffer poor longer term outcomes. Approximately 1 in …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Julia Kay Waid-Ebbs · VETERANS HEALTH ADMINISTRATION · 2024 — Background. Over 70% of Veterans with mild traumatic brain injury (mTBI), seeking services at the Veterans’ Health Administration, suffer from comorbid post-traumatic stress disorder (PTSD). These Veterans commonly experience concomitant executive dysfunction in goal setting, concentration, and atte…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Jenna Bartley · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · 2024 · $415,416 — PROJECT SUMMARY Despite widespread vaccination, influenza (flu) remains a leading cause of death among older adults. Vaccination is the most effective way to prevent infectious disease. However, older adults have dysregulated immune responses that reduce vaccine efficacy and leave them at risk for s…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Hamideh Parhiz · FRED HUTCHINSON CANCER CENTER · 2024 · $849,858 — PROJECT SUMMARY/ABSTRACT Modification of autologous T cells with chimeric antigen receptor (CAR) molecules was first proposed nearly 30 years ago as a therapy for people living with HIV. Since then, CAR-T cells have emerged as a potent and highly successful therapy for liquid tumors, while HIV-speci…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Kathryn Edin · PRINCETON UNIVERSITY · 2024 · $1,337,632 — Project Summary/Abstract: FRAGILE FAMILIES AND CHILD WELLBEING – YOUNG ADULTHOOD The Fragile Families and Child Wellbeing Study (FFCWS) is a birth cohort study following a stratified, multistage, population-representative sample of children born in large US cities between 1998 and 2000. This proposa…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
WILLIAM M GEISLER · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2024 · $151,812 — This application is for a renewal of my K24 Midcareer Investigator Award in Patient-Oriented Research (POR) on Chlamydia trachomatis (CT) Infections. I, Dr. William Geisler, am a federally-funded physician scientist at the University of Alabama at Birmingham (UAB) with expertise in CT infections and…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Michael John Hogan · UNIVERSITY OF PENNSYLVANIA · 2024 · $160,205 — PROJECT SUMMARY The basis of cellular immunity is the recognition by T cells of foreign peptides in association with major histocompatibility complex (MHC) proteins on the cell surface. CD8 T cells, the subset most associated with cytolysis, are conventionally believed to recognize peptides bound to…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Jeremy Marston · TEXAS TECH UNIVERSITY · 2024 · $220,683 — Project summary Injectable drugs constitute a $400+ billion market worldwide, and the range of devices for delivery is expanding to improve factors such as patient compliance, reduced pain, self-administration, and delivery efficiency. Intradermal delivery is especially pertinent in this regard for …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Jamie Faro · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2024 · $162,485 — PROJECT SUMMARY Cancer survivors have 1.7-18.5-fold increased risk, and 1.3-3.6-fold increased mortality of cardiovascular disease (CVD). Physical activity has been shown to ameliorate risk, but survivors’ levels are far below the general population. Due to this, provider physical activity recommend…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
ALICE S. RYAN · SOUTH TEXAS VETERANS HEALTH CARE SYSTEM · 2024 — Findings of post-acute sequelae of Post-COVID Conditions (PCC) manifestations of fatigue, pain, dyspnea, and muscle weakness, provide a strong rationale for rehabilitation; yet few formal studies exist and the effects of severe acute respiratory syndrome coronavirus-2 infection on function are not w…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Ippolytos Andreas Kalofonos · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · 2024 — Veterans with Serious Mental Illness (SMI) struggle with social integration - participation in work, housing, and citizenship - due to symptoms, stigma, and psychosocial functioning deficits. This has a tremendous impact on mortality, comparable to that of smoking and greater than obesity and alcoho…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Irwin N. Sandler · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · 2024 · $196,250 — Abstract Parental death is one of the most stressful events of childhood and is associated with increased risk for multiple mental health problems as well as impairments in developmental competencies in childhood and adulthood. This study uses a secondary data analysis of a 15-year longitudinal stud…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
SETH D POLLAK · UNIVERSITY OF WISCONSIN-MADISON · 2024 · $230,918 — The American Academy of Pediatrics includes child poverty on its list of the most-dire health issues facing children. Child poverty is a multi-determined complex problem with well-documented correlations to profound and enduring negative effects on health and behaviors across the lifespan. Criticall…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
PHILIP J SANTANGELO · EMORY UNIVERSITY · 2024 · $709,376 — Project Summary There are over 200 viruses known to infect humans and they contribute to 6.6% of global mortality. We have approximately 91 drugs for 10 viral species and vaccines for only 16. Reassortment and antigenic changes pose challenges to vaccine efficacy; this has clearly been demonstrated …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Vijay Rathinam · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $637,370 — ABSTRACT Type I interferons (IFN) and IFN stimulated genes (ISGs) provide broad antiviral activities. However, the host protection provided by the IFN and ISGs during bacterial infections is not well defined. This proposal will define new innate immune functions of Oligoadenylate Synthetase (OAS) pr…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Rudolph c Johnson · JAMES A. HALEY VA MEDICAL CENTER · 2024 — Obesity continues to escalate as a significant public health problem and as the leading preventable cause of death. Stark data from COVID19 pandemic shows obesity is an independent risk factor of severity with 33% mortality rate. Obesity per se is not fatal but is the major health risk factor promot…