NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Philippa Clarke · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $503,447 — The COVID-19 pandemic has resulted in substantial changes to American neighborhoods in ways that are only beginning to be elucidated. There has been an excess of permanent business closures, particularly among small neighborhood businesses most vulnerable to social distancing, such as local barber s…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Jing Pan · UNIVERSITY OF FLORIDA · 2024 · $158,008 — Project Summary/Abstract Sepsis is one of the major healthcare problems in the United States with an annual patient care cost approaching $23 billion. Despite a substantial decrease in inpatient mortality over the past 15 years, the current epidemiology indicates a disturbing increase in the number…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Alina Schnake-Mahl · DREXEL UNIVERSITY · 2024 · $127,764 — PROJECT SUMMARY The purpose of this K01 proposal is to provide Alina Schnake-Mahl, ScD MPH with the protected time and resources to pursue the additional training needed to reach her long-term goal of an independent academic career in health policy and social epidemiology, focused on generating evid…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Lachlan James Smith · UNIVERSITY OF PENNSYLVANIA · 2024 · $12,410 — Abstract The Orthopaedic Research Society (ORS) Spine Section is the premier professional body devoted to basic and translational spine research, and an indispensable scientific forum for investigators at all career stages. While Spine Section Symposia have been held successfully as sub-meetings of…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Kara W Chew · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $1,435,214 — PROJECT SUMMARY/ABSTRACT This U01-supported clinical trial will test a unique T follicular helper (Tfh)-targeting vaccine approach, “s3”, that we predict will generate exceptionally broad and long-lived antigen-specific antibody responses, characteristics likely to result in resilient vaccines that …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
John Lucian Davis · YALE UNIVERSITY · 2024 · $166,091 — PROJECT SUMMARY Nearly one-third of the 10 million annual tuberculosis (TB) cases worldwide are missed each year. TB contact tracing is an evidence-based practice that is internationally recommended for finding, treating, and preventing TB among close contacts of TB patients. Contact tracing is also…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Donna L. Farber · SCRIPPS RESEARCH INSTITUTE, THE · 2024 · $884,886 — Project Summary/Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2), has exploded into a global pandemic causing significant loss of life, pronounced economic impact and significant long-term medical impacts which are still being char…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Sue Ann Soyoung Lee · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · 2024 · $526,834 — PROJECT SUMMARY/ABSTRACT Although the Individuals with Disabilities Education Act (IDEA) ensures that all children with disabilities are provided with appropriate public education, there is an increasing inequity in the provision of speech- language services across the U.S. due to the critical shor…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Melissa Wei · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $611,706 — Project Summary / Abstract Virtually all U.S. adults will develop multimorbidity (coexistence of multiple chronic conditions) by late adulthood. The sequelae are substantial: vulnerability to acute illness, disease exacerbation, hospitalization, disability, poor health-related quality of life, and m…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Seethal Jacob · INDIANA UNIVERSITY INDIANAPOLIS · 2024 · $184,130 — Sickle cell disease (SCD) is the most common inherited hematologic disease. Studies have shown that comprehensive medical care can decrease adverse outcomes associated with SCD, but such care is not easily accessed. It is estimated that less than 70% of children with SCD receive comprehensive care, …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Lorraine B Ware · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $431,046 — Sepsis with acute organ dysfunction is a common condition with high morbidity and mortality and no specific therapies other than antimicrobials. The NHLBI PETAL Network Phase 2B Acetaminophen and Ascorbate in Sepsis: Targeted Therapy to Enhance Recovery (ASTER trial) is a randomized double blind pla…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Rocio Calvo · BOSTON COLLEGE · 2024 · $572,179 — Project Summary Latinxs, particularly those with mental illness, are at higher risk of COVID-19 infection, and associated morbidity and mortality, and yet have lower rates of vaccination, than non-Latinx whites. This pattern is not unique to COVID-19; it has been observed for other infectious diseas…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
ALISON G CAHILL · UNIVERSITY OF PENNSYLVANIA · 2024 · $665,371 — PROJECT ABSTRACT More than one million women undergo labor induction in the U.S. annually and over one-third of inductions end in cesarean delivery (CD). While many factors contribute to the CD rate, shifting the start of labor induction (e.g. cervical ripening) from an inpatient to outpatient setti…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Mary Catherine Cambou · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $203,580 — PROJECT SUMMARY/ABSTRACT While the clinical spectrum of SARS-CoV-2 infection in pregnancy ranges from asymptomatic to critical disease, pregnancy itself augments the risk of severe and critical COVID-19. The leading obstetrical societies in the U.S. recommend COVID-19 messenger RNA (mRNA) vaccinatio…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
JOSIEMER MATTEI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · 2024 · $1,884,576 — PROJECT SUMMARY Access to sufficient, high-quality, and safe food and nutrition is a fundamental human right. Lacking this denotes food insecurity (FI), becoming a significant societal and public health crisis. FI increases the risk of type 2 diabetes and cardiovascular disease. Yet, there is insuf…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
DAVID H BECHHOFER · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $354,900 — PROJECT SUMMARY: Our laboratory has, for many years, studied the essential process of mRNA decay in the model Gram-positive bacterium, Bacillus subtilis. We have identified several ribonuclease (RNase) enzymes of B. subtilis and have elucidated the role they play in mRNA turnover. The viability of a…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Laura Kathleen Clary · JOHNS HOPKINS UNIVERSITY · 2024 · $655,853 — ABSTRACT. Systemic racism exposes Black and Latinx adolescents to a range of traumatic stressors, including publicized instances of police brutality toward Black people, stressful personal interactions with hostile police officers, and oppressive immigration policies. The combination of systemic rac…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Eunice Na Young Kim · STATE UNIVERSITY NEW YORK STONY BROOK · 2024 · $41,340 — PROJECT SUMMARY Airway motile cilia play an important role in mucociliary clearance, the primary innate defense mechanism of the lung, by propelling inhaled pathogens trapped in mucus up and out of the respiratory tract. Impaired ciliary function is commonly found in patients with chronic pulmonary …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Dong Liang · TEXAS SOUTHERN UNIVERSITY · 2024 · $2,333,566 — PROJECT SUMMARY Texas Southern University (TSU) is requesting continuous RCMI U54 support for the Center for Biomedical and Minority Health Research (CBMHR) formerly known as the Center for Biomedical and Health Research Excellence under the G12 mechanism. The purpose of the CBMHR is to support basi…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Abha K Rajbhandari · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $202,800 — PROJECT SUMMARY/ABSTRACT The fundamental mechanisms by which acute intense stress affects energy homeostasis via brain substrates and sexual dimorphism of these processes are poorly understood. Environmental stressors induce fight-or- flight-or-freeze response via the locus coeruleus (LC) in the bra…