Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Julian HENLEY · HENLEY ION, LLC · 2024 · $832,868 — PROJECT SUMMARY Many pathogens, such as severe acute respiratory coronavirus 2 (SARS-CoV-2) and Mycobacterium tuberculosis, spread via aerosol transmission and inflict global public health and economic consequences. SARS-CoV-2 has infected over 450 million people, led to over 6 million fatalities, a…
Yoko Nomura · QUEENS COLLEGE · 2024 · $727,378 — Summary/Abstract: Accumulating evidence, including our own, indicates that in utero exposure to psychosocial stress is associated with risks for elevated anxiety (ANX) and disruptive behavior (DB) symptomatology. In this application, we will build on our existing birth cohort of children exposed and…
Connie Krawczyk · VAN ANDEL RESEARCH INSTITUTE · 2024 · $249,064 — ABSTRACT Sex and gender contribute to the immune system and how we as humans respond to foreign infections. Males traditionally have an elevated risk of hospitalizations due to infections from birth to old age. Females, however, have a more protective immune system, yet have an elevated risk of auto…
Laura Pilar Gelfman · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $167,035 — ABSTRACT Persons with serious illness suffer from poor symptom control, decreased quality of life (QoL) and poor communication with their healthcare providers, especially in terms of goals of care discussions (GOCD). Palliative care, when offered alongside disease management, offers improved symptom…
Jennifer R Fonda · VA BOSTON HEALTH CARE SYSTEM · 2024 — The overall aim of this proposed study is to use machine learning prediction models to evaluate the multifaceted, additive and multiplicative interactions of known and novel risk factors for opioid use disorder (OUD) and overdose in Post-9/11 Veterans. The proposed study will also investigate the sh…
Chiara Giannarelli · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $768,169 — PROJECT SUMMARY The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remains a global health concern and despite the fast-track development of vaccines and the imminent prospective of new antiviral drugs, is expected to become ende…
John F Alcorn · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $518,055 — SUMMARY Despite intense research focus, Staphylococcus aureus has remained an important cause of both community acquired pneumonia and viral-related super-infections. The field has recently determined host mediated mechanisms induced by S. aureus that drive lung infection and injury. In the context …
GEORGE ENG · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $196,204 — Project Summary/Abstract This proposal details a five-year training plan for the development of a research program focused on elucidating the therapeutic potential of superimposed additional Wnt signaling on colonic neoplasia. The molecular driver shared across the vast majority of colonic neoplasms…
Sina Tavakoli · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $608,894 — ABSTRACT Aberrant immune response to injury is a major pathogenic driver of adverse extracellular matrix remodeling after acute lung injury (ALI) and a wide range of fibrotic lung diseases (referred to inflammation-fibrosis axis). However, there is currently no established approach for noninvasive a…
Anne M. Manicone · UNIVERSITY OF WASHINGTON · 2024 · $717,227 — ABSTRACT With the surge of ARDS cases associated with SARS-CoV-2 infection, there is an urgent need to understand novel pathways involved in resolution of lung inflammation and injury to provide the basis for new therapeutic approaches. Studies comparing rodent and human lung injury gene expression …
RACHEL F. BARR · GEORGETOWN UNIVERSITY · 2024 · $526,578 — Overall Project summary Rapid growth in access to digital media is accompanied by a scarcity of research examining complex, real-time family media context and sociocognitive outcomes, driven in part by a lack of comprehensive measurement tools. To meet this challenge, the PI’s interdisciplinary re…
Jason Colditz · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $172,575 — PROJECT SUMMARY/ABSTRACT Alcohol Use Disorder (AUD) is a common and serious health condition. The COVID-19 pandemic worsened AUD trajectories and heightened barriers to accessing treatment and peer support that are effective in improving AUD outcomes. A growing number of people are seeking AUD recov…
Xingbin Ai · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $208,750 — PROJECT SUMMARY COVID-19 (CoV19) is caused by SARS-CoV-2 infection of the airway epithelium resulting in extensive damage in the lower respiratory tract. Since 2020, CoV19 has claimed over 1 million lives in the United States surpassing the death toll of the 1918 H1N1 influenza pandemic. Clinical st…
William Joseph Crandall · EMORY UNIVERSITY · 2024 · $48,974 — ABSTRACT Herbal dietary supplements and medicines are used as the primary form of health care for about eighty percent of the world’s population. In the United States, the use of these botanicals is increasing, accounting for $11.26 billion in sales in the past year alone. Despite widespread and inc…
Gregory David Ebel · COLORADO STATE UNIVERSITY · 2024 · $335,392 — Arthropod-borne viruses (arboviruses) adapt to local conditions, maximizing their potential to perpetuate and emerge as health threats. The adaptive potential of arboviruses is driven by error-prone replication, which creates a genetically diverse pool of competing virus genotypes within each host. …
Peggy Timothe · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · 2024 · $135,000 — Project Summary /Abstract The proposed Biomedical Informatics and Behavioral Sciences (BIBS) Summer Research Program seeks to encourage underrepresented students to pursue oral health research careers. In 2000, Oral Health in America: A report of the Surgeon General reframed oral diseases as a bona …
FREDERICK R BLATTNER · DNASTAR, INC. · 2024 · $681,914 — The B cell population in each individual produces an estimated 1010 different antibodies, collectively known as the antibody repertoire. This extraordinary diversity is essential for responding to the unique history of infections, vaccinations and cancer encountered over an individual’s lifetime. Co…
BRIAN W FOUTY · COMPOVAX, LLC · 2024 · $294,877 — PROJECT SUMMARY/ABSTRACT The success of mRNA vaccines in controlling the COVID 19 pandemic has confirmed the efficacy of mRNA and has also provided a blueprint on how to construct these vectors in terms of structure and cost. We have recently developed a new mRNA platform that, unlike current mRNA v…
PINGSHENG WU · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $246,832 — PROJECT SUMMARY/ABSTRACT: This application is being submitted to PA-20-272 in accordance with NOT-OD-22-137. We propose to leverage the infrastructure of the parent study (R01 AI143710), a large population-based birth cohort of over 3,000 individuals with Down syndrome (DS), an experienced study tea…
Timothy Notton · AUTONOMOUS THERAPEUTICS, INC. · 2024 · $273,644 — PROJECT SUMMARY/ABSTRACT This project will use synthetic biology to engineer RNA-based sensors of viral infection for the high-throughput discovery of new classes of antivirals—including novel, pan-variant antivirals that can maintain broad-spectrum antiviral efficacy. State-of-the-art antiviral the…