NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
CARL Francis NATHAN · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $3,048,982 — ABSTRACT Unless COVID overtakes it, tuberculosis is likely to keep its grip on its grim record of being the leading infectious cause of human death. Humans are the only known natural host and transmitting reservoir for the causative agent, Mycobacterium tuberculosis (Mtb). This means that person-to-…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Sung-Hee Lee · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $388,052 — Longitudinal studies of the population near, through and after the retirement stage, such as the Health and Retirement Study (HRS), play an important role in aging research because they provide data from a life course perspective, allowing researchers to make population-level causal inference. Becau…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
KAREN Ann LAWRENCE · UNIVERSITY OF KENTUCKY · 2024 · $125,795 — Dementia and the prodromal stages of cognitive decline, together, affect approximately 25-30% of older adults across the United States (U.S.). Posttraumatic Stress Disorder (PTSD) has been linked to a 111% increased risk of developing dementia of any type, even after controlling for potential confou…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Charles C Miller · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 2024 · $974,000 — : The recent pandemic dramatically highlighted the need for a well-trained, highly adaptable clinical and translational science workforce; especially one that is capable of rapid design and deployment of clinical trials and key capabilities that accelerate research translation. The University of Tex…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Nikki Gentile · UNIVERSITY OF WASHINGTON · 2024 · $656,157 — Project Summary/Abstract Post-acute sequelae of COVID-19 (PASC), or “Long-COVID” has negatively impacted millions of individuals with regard to quality of life, daily functioning, and ability to work, and has placed enormous demands on the healthcare system. Pain-related symptoms are reported by alm…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
YOONSUN CHOI · UNIVERSITY OF CHICAGO · 2024 · $861,532 — PROJECT SUMMARY: The high rates and upward trend of mental health (MH) problems among young Asian Americans (AAs) are disturbing. Despite mounting evidence of MH crisis, AAs are severely understudied, exacerbating health disparities. Spikes in sociopolitical tensions and racial hostility in recent y…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Xintian Feng · Q-CHEM, INC. · 2024 · $660,205 — Q-Chem is a state-of-the-art commercial computational quantum chemistry software program that has aided about 60,000 users in their modeling of molecular processes in a wide range of disciplines, including biology, chemistry, and materials science. In this proposal, we seek to significantly reduce t…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Harry P. Selker · TUFTS UNIVERSITY BOSTON · 2024 · $11,215,948 — TUFTS CTSI OVERALL PROJECT SUMMARY Over its 14 years, Tufts Clinical and Translational Science Institute (CTSI) has brought together partners and collaborators and has grown programs and activities to catalyze clinical and translational research (CTR) and to advance innovation in clinical and transl…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Natalie Hiromi Brito · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $718,360 — PROJECT SUMMARY The prenatal period is regarded as one of the most sensitive phases in human development. Events that occur during gestation can alter the course of development with lasting impact. Presently, the COVID-19 pandemic is exerting wide-spread impact on the lives of expectant mothers arou…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Luis J Montaner · WISTAR INSTITUTE · 2024 · $5,736,593 — Summary Current HIV curative strategies have proven insufficient to eradicate viral reservoirs or prevent viral rebound after antiretroviral therapy (ART) cessation. The unifying hypothesis for the BEAT-HIV Collaboratory is that through a better mechanistic understanding of HIV latent reservoirs and…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
ESTHER J CALZADA · GEORGE WASHINGTON UNIVERSITY · 2024 · $811,056 — Abstract In 2021, the US Surgeon General issued an advisory warning of a youth mental health crisis, exacerbated by the COVID-19 pandemic. Latinx youth, a group marginalized by race, ethnicity, class, and culture, have exceedingly high rates of internalizing symptoms such as depression and anxiety.…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
PAUL JOSEPH UTZ · STANFORD UNIVERSITY · 2024 · $762,036 — PROJECT SUMMARY/ABSTRACT The overarching goal of the proposed study is to better understand COVID-19 vaccine immunogenicity in immunocompromised individuals, particularly patients with connective tissue diseases (CTDs) and other musculoskeletal disorders. A paucity of data exists regarding vaccine s…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Marian Patricia Jarlenski · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $763,485 — Project Summary/Abstract Rates of severe maternal morbidity (SMM) and mortality continue to rise in the US and have been exacerbated during the pandemic. The significant racial inequities in SMM and mortality are a public health crisis and are a result of historical and contemporary structural and s…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Sarah Peregrine Lord · EMPATHY ROCKS INC · 2024 · $219,212 — Abstract It is estimated that more than one in five U.S. adults live with a mental illness (57.8 million), with many racial and ethnic minorities (REM) groups reporting higher risk of persistence and disability from mental illness than their White counterparts. Despite widespread demand, more than h…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Sujan Shresta · LA JOLLA INSTITUTE FOR IMMUNOLOGY · 2024 · $894,640 — Project Summary The long-term goal of this project is to develop a vaccine that confers robust and durable protection against transplacental transmission of Zika virus (ZIKV). Accomplishing this goal may be challenging in that the vaccine may need to induce both antibody and T cell responses to conf…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Luis R Rodriguez · UNIVERSITY OF PENNSYLVANIA · 2024 · $162,540 — Abstract Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease of unknown cause marked by dysfunctional wound healing and aberrant fibrotic remodeling of the lung that claims the lives of more than 40,000 Americans each year. The median age of IPF is 66 years and patients have an average life …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Lindsay C Kobayashi · TRUSTEES OF INDIANA UNIVERSITY · 2024 · $745,584 — PROJECT SUMMARY By 2050, over 75% of Alzheimer’s disease and related dementia (ADRD) cases are projected to occur in low- and middle-income countries, such as South Africa. Government cash transfer programs as a form of social protection may increase individual and household income, with implication…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Anna Helena Jonsson · UNIVERSITY OF COLORADO DENVER · 2024 · $167,875 — Project Summary/Abstract This proposal is a five-year research and training plan with a scientific focus on interactions between CD8 T cells and fibroblasts in synovial tissue from patients with rheumatoid arthritis (RA). We have found that the majority of CD8 T cells in RA synovium have an unusual …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Abbey Porzucek · YALE UNIVERSITY · 2024 · $48,974 — Project Summary New solutions are desperately needed to reduce the annual global burden of dengue. As we have witnessed for SARS-CoV-2, virus genomics can be harnessed to directly inform public health control measures. However, for most other pathogens, including dengue virus, the depth of genomic i…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Sofia Caryotakis · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $45,909 — Project Summary Respiratory viral infections are a prevalent and ongoing threat to global health, as evidenced by seasonal Influenza A infections and the SARS-CoV-2 pandemic. Notably, the association between allergy and asthma and the severity of respiratory viral illness has been long observed but …