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9873 documents

Early Puberty During the COVID-19 Pandemic in a Multi-Ethnic, Population-Based Cohort of Children and Adolescents

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Julia Acker · UNIVERSITY OF CALIFORNIA BERKELEY · 2024 · $46,614 — PROJECT SUMMARY Early puberty is associated with adverse health outcomes over the life course, including psychopathology in adolescence, and reproductive cancers, diabetes, and cardiovascular disease in adulthood. The age of pubertal onset has declined dramatically over the past 40 years in the Uni…

Development and characterization of self-amplifying RNA Lipid Nanoparticles for potent and multiplex gene expression in solid tumors

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Arun Kannoth Nambiar · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · 2024 · $40,671 — Project Summary Specific Aims Solid tumors account for nearly 90% of adult cancers and are challenging to eliminate. Surgery and adjuvant therapy (e.g., radiation, chemotherapy, and immunotherapy) are powerful methods for treating solid tumors. Still, they are not universally effective or curative,…

Community-Academic Partnerships to Address COVID-19 Inequities within African American Communities

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Tiarney D Ritchwood · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2024 · $930,000 — Abstract In a few months’ time, the emergence of the coronavirus disease (COVID-19), a highly contagious disease resulting from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), sickened millions and killed hundreds of thousands of people in the United States alone. As with many othe…

Understanding the Nature and Impact of LGBTQ+ Microaggressions in Cancer Genetic Counseling Encounters

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Nao Hagiwara · VIRGINIA COMMONWEALTH UNIVERSITY · 2024 · $100,000 — Project Summary / Abstract Despite decades of effort to reduce racial cancer disparities, Black people continue to die at higher rates from cancer than any other U.S. racial group. Because prevention is the key to the cost-effective and long-term control of cancer, the potential for cancer genetic c…

Impacts of Telehealth Policies on Inequities in Perinatal Behavioral Health Care Access and Outcomes

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Laura Johnson Faherty · RAND CORPORATION · 2024 · $677,945 — Project Abstract: Suicide is now the leading cause of death during the perinatal period, and nearly a quarter of maternal deaths are attributable to behavioral health (BH) conditions. As with maternal mortality and morbidity overall, poor perinatal BH outcomes disproportionately affect historically …

Improving access to opioid use disorder treatment among marginalized patients with a tailored telehealth intervention

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Shoshana V. Aronowitz · UNIVERSITY OF PENNSYLVANIA · 2024 · $75,600 — PROJECT SUMMARY/ABSTRACT: The goal of this K23 award is to give the PI the skills and preliminary data needed to improve access to opioid use disorder (OUD) treatment with buprenorphine among marginalized individuals via telehealth care. Dr. Aronowitz is proposing a research and career development p…

COVID-19 Mitigation Efforts and Disparities in Access to Routine Preventive Care and Chronic Disease Management

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Cameron Maxwell Kaplan · UNIVERSITY OF SOUTHERN CALIFORNIA · 2024 · $468,962 — As a result of mitigation policy and behavioral changes, the COVID-19 pandemic significantly reduced access to primary care, which is likely to have lasting effects on chronic disease management and health outcomes, particularly for under-resourced populations with existing chronic conditions. Newly…

BLRD Research Career Scientist Award Application

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Philip N. Rather · VETERANS HEALTH ADMINISTRATION · 2024 — Project Summary. The Gram-negative bacterium Acinetobacter baumannii is a leading cause of infections in both the hospital setting and in injured military personnel. The goal of this Research Career Scientist Award is to continue addressing the mechanisms that regulate virulence and β−lactam resist…

Real-time tracking of virus evolution for vaccine strain selection and epidemiological investigation

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Trevor BC Bedford · FRED HUTCHINSON CANCER CENTER · 2024 · $418,074 — Project Summary Viral pathogens are an enduring threat to global public health. This project aims to use viral genomic data to improve understanding of ongoing virus evolution and to make actionable inferences to reduce the global burden of viral infectious disease. In order to be relevant for publi…

Early life respiratory viral infections shape immune development trajectories

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Maria Virginia Pascual · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · 2024 · $1,688,409 — Abstract Viral respiratory infections are responsible for major morbidity and mortality in early life. Infants account for a significant proportion of influenza hospitalizations and are considered a top high-risk group. In addition to the acute morbidity, initial immune responses to influenza shape/…

The Translational Efficiency of Linking Family and Household Members to Study and Intervene on the Ripple Effects of Trauma

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Lauren A Magee · INDIANA UNIVERSITY INDIANAPOLIS · 2024 · $79,250 — PROJECT SUMMARY/ABSTRACT Rates of firearm injuries reached unprecedented levels during the COVID-19 pandemic, disproportionally represented women and children, and rates remain at historical high levels in 2023. Exposure to firearm injury is associated with increased adverse health outcomes and ment…

Research Employing Environmental Systems and Occupational Health Policy Analyses to Interrupt the Impact of Structural Racism on Agricultural Workers and Their Respiratory Health (RESPIRAR)

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Devon C Payne-Sturges · UNIV OF MARYLAND, COLLEGE PARK · 2024 · $725,116 — Structural racism (SR) has been defined as the macro level systems, social forces, institutions, ideologies, and processes that interact with one another to generate and reinforce inequities among racial/ethnic groups. The mechanisms of SR are “unseen” and thus understudied and typically not incorpo…

Viral Diversity an Innovative Biomarker for Refining Estimates of HIV Incidence

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Sikhulile Moyo · THE BOTSWANA HARVARD HEALTH PARTNERSHIP · 2024 · $136,460 — Project Summary Candidate: Dr Sikhulile Moyo is unwaveringly committed to an overarching career focused on contributing to ending the HIV epidemic and related public health emergencies. He committed to a career focused on finding cost-effective tools for estimating the impact of interventions and to…

Housing Policies and their Impact on Engagement in Substance Use Treatment and Overdose Risk during the COVID-19 Pandemic

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Matthew Eisenberg · JOHNS HOPKINS UNIVERSITY · 2024 · $707,029 — Project Summary Substance use disorder (SUD), overdose risk, and housing insecurity have reached crisis levels in the US. In 2019, over 8 million individuals met criteria for SUD, and nearly 37 million households were spending more than 30% of their income on housing. Since the start of the COVID-19…

High-Intensity Interval Training to Recover Walking Post-Stroke: HIT-Stroke Trial 2

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Pierce Boyne · UNIVERSITY OF CINCINNATI · 2024 · $679,886 — PROJECT SUMMARY / ABSTRACT Among the 7 million stroke survivors living in the U.S., fewer than 10% have adequate walking speed and endurance to complete normal daily activities like grocery shopping, which leads to a loss of life roles. Stroke rehabilitation guidelines recommend moderate-intensity a…

A dyadic exercise approach to prevent declines in physical and mental health in couples during radiation treatment for cancer: a hybrid type I efficacy-implementation trial

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

KERRI M WINTERS-STONE · OREGON HEALTH & SCIENCE UNIVERSITY · 2024 · $525,495 — Breast and prostate cancer are two of the most common and survivable cancers and most survivors of these cancers will be married when diagnosed. Compared to couples that aren't facing a chronic illness, both cancer survivors and their spouses suffer from poorer physical and mental health that leads …

Improved Understanding of Bacterial Sortase Activity Towards Next-Generation Protein Engineering

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Jeanine Faye Amacher · WESTERN WASHINGTON UNIVERSITY · 2024 · $382,912 — Project Summary. Sortase enzymes are cysteine transpeptidases located on the cell surface of Gram-positive bacteria, which attach a variety of proteins to the peptidoglycan cell wall. The first sortase discovered, the Class A sortase from Staphylococcus aureus (saSrtA), is widely used in sortase-med…

Monocyte-derived alveolar macrophage drives inflammatory response to lung ozone exposure

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Alexander Misharin · DUKE UNIVERSITY · 2024 · $586,846 — Abstract: Morbidity and mortality associated with ozone (O3) exposures are a substantial public health concern. Unlike other environmental exposures, O3-related morbidity and mortality, is largely linked to respiratory causes and associated with pre-existing respiratory conditions. However, specific…

Functional consequences of the interactions between tau protein and opioids

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Brady Atwood · UNIVERSITY OF MINNESOTA · 2024 · $239,963 — PROJECT SUMMARY The opioid epidemic is a persistent public health crisis that has been worsened by the COVID19 pandemic. Efforts to curtail this epidemic have had minimal success in halting its continued progression. There is a critical need to more fully understand the neurobiology of opioid use di…

Adaptive Interventions to Improve Alcohol Treatment Engagement among Alcohol-related Liver Disease Patients

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Jessica Leigh Mellinger · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $645,878 — Project Summary Alcohol-related liver disease (ALD) rates have risen 40% in recent years with mortality rising 3.4% per year over the last 15 years. Alcohol treatment, even just one session, improves liver disease mortality and liver function, but only 10-15% of ALD patients engage in treatment afte…