Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Tian Wang · UNIVERSITY OF TEXAS MED BR GALVESTON · 2024 · $247,852 — PROJECT SUMMARY Chikungunya virus (CHIKV), a mosquito-borne RNA virus, causes chikungunya fever (CHIKF), typically accompanied by severe, debilitating and often chronic arthralgia. The virus was first associated with human disease in the 1950s in Tanzania, and has re-emerged, causing epidemics in Af…
Elizabeth Gross Cohn · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $4,048,432 — ABSTRACT: Despite medical advances in treating chronic diseases and epidemiological findings identifying risk factors for chronic diseases, there remain major persistent health disparities driven by the Social Determinants of Health (SDoH). We have come together to address these disparities through …
Thomas M McIntyre · CLEVELAND CLINIC LERNER COM-CWRU · 2024 · $560,893 — Hypertension, for unknown reasons, is a primary co-morbidity risk factor for poor COVID-19 outcomes. SARS- Cov-2 breaches the lung blood-air barrier to spread among organs inducing endothelial cell dysfunction and multi-organ thromboembolism. ACE2 is the high affinity receptor for SARS-Cov-2 with TM…
Kathleen M Gray · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $247,705 — Iterative Design to Engage All Learners ABSTRACT In 2016, high levels of per- and polyfluoroalkyl substances (PFAS) were discovered in the Cape Fear River in eastern North Carolina (NC), part of NC's largest watershed and drinking water supply for over 1 million people. More recently, PFAS were det…
LISA J BERLIN · UNIVERSITY OF MARYLAND BALTIMORE · 2024 · $531,935 — Project Summary/Abstract Latino children have worse health than non-Latino White children across many common conditions, including respiratory illnesses and obesity, laying a foundation for health disparities across the life course. Prior studies demonstrate that attachment-based parenting intervent…
Hiam Naiditch · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $90,932 — PROJECT SUMMARY/ABSTRACT: Survivors of critical illness often face significant challenges, such as neurocognitive disorders, physical disabilities, and respiratory limitations. Healthcare disparities by race heighten such challenges. Risk prediction tools designed to identify high-risk patients for …
Jasmine Wright · WASHINGTON UNIVERSITY · 2024 · $35,482 — Project Summary/Abstract Obesity is a global health concern as it is a risk factor for several of the leading causes of death such as heart disease, kidney disease, and type 2 diabetes. Obesity drives dysregulated inflammation, which has been shown to be a risk factor for increased morbidity and mor…
Aaron D Fox · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2024 · $184,804 — Mentorship in research on opioid use disorder, HIV and marginalized populations People who inject drugs (PWID) are at high risk for overdose and increasing HIV risk, yet they sub-optimally receive evidence-based opioid use disorder (OUD) treatment and HIV prevention measures. Engaging PWID and perso…
Jay R Radke · BOISE VA MEDICAL CENTER · 2024 — Over 25% of US Veterans have diabetes, and those Veterans are at an increased risk of hospitalization and increased morbidity/mortality following severe respiratory viral infections, such as, influenza (H1N1), SARS- CoV-2 (COVID) and adenovirus (Ad). Infection with these respiratory viruses causes a…
Nir Hacohen · BROAD INSTITUTE, INC. · 2024 · $210,516 — The development of scalable, cost-effective antibody libraries for detecting proteins (or other molecules) has greatly lagged the development of methods for detecting (e.g. by hybridization or sequencing) specific RNA or DNA sequences. If we were able to engineer antibodies against diverse targets a…
RICHA SAXENA · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $351,594 — Abstract A hallmark of infection with SARS-CoV-2 is the unpredictable variation in individual health response from those who are asymptomatic to those with life-threatening and refractory respiratory illness, and finally those with long lasting symptoms, here defined as Long COVID. The core symptoms…
Meriah L DeJoseph · STANFORD UNIVERSITY · 2024 · $77,284 — PROJECT SUMMARY Poverty-related adversities place children at an increased risk for developing behavioral self-regulation difficulties that disrupt their capacity to learn and thrive across the lifespan. With nearly 12 million children growing up in poverty in the United States, this represents a mo…
Andrea Levine · UNIVERSITY OF MARYLAND BALTIMORE · 2024 · $154,500 — ABSTRACT Acute Respiratory Distress Syndrome (ARDS) is a highly fatal condition characterized by diffuse pulmonary infiltrates and severe hypoxemia. The outcomes of ARDS are significantly worse in older adults, a finding that has been underscored by the ongoing COVID-19 pandemic. ARDS is known to be…
Brian K Shoichet · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $798,338 — Abstract Our long-term goal is to develop structure-based and chemoinformatic methods in ligand discovery, testing these in experimental model systems and applying them to targets of biological interest. To give the reader a sense of our direction, we sketch several questions within four broad foci:…
Nicole Renee Bush · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · 2024 · $1,411,775 — Over 25% of children suffer from mental health problems and/or develop obesity. Mental health problems often emerge early through a broad range of symptoms before canalizing into disorders like depression, which affects over 15% of adolescents in the U.S. Risk for obesity also increases with age fro…
MALAZ BOUSTANI · TRUSTEES OF INDIANA UNIVERSITY · 2024 · $789,359 — PROJECT SUMMARY/ABSTRACT Among patients with Alzheimer’s disease and related dementias (ADRD) and their informal caregivers, behavioral and psychological symptoms of dementia (BPSD) are a critical need requiring scalable, evidence- based intervention. As many as 97% of patients with ADRD will ultima…
Andrew Michael Smith · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · 2024 · $587,866 — ABSTRACT More than 42% of adults in the United States live with obesity, a condition characterized by excess body fat primarily within adipose tissue. Obesity is a risk factor for type 2 diabetes, cardiovascular diseases, cancer, and severe COVID-19 disease and has few widely effective non-surgical …
Hing Hung Henry Lai · WASHINGTON UNIVERSITY · 2024 · $474,999 — PROJECT SUMMARY Urinary Stone Disease (USD) is an increasingly prevalent and highly recurrent condition associated with major morbidity at a rising cost to society. Thus, improved management can significantly reduce its health burden. Increasing fluid intake is recommended to all USD patients. Howev…
Daniel Blanco-Melo · FRED HUTCHINSON CANCER CENTER · 2024 · $508,951 — Project Summary Viruses have imposed a significant global burden of morbidity and mortality for millennia. Just in the last century, highly pathogenic RNA viruses such as influenza A, HIV and SARS-CoV-2 resulted in devastating pandemics that directly impacted millions of individuals and altered soci…
Arielle Hope Sheftall · UNIVERSITY OF NOTRE DAME · 2024 · $735,649 — PROJECT SUMMARY / ABSTRACT Over the past two decades, suicide rates have increased nearly 35% in the U.S., with up- ward trends in nearly all demographic groups. Further increases have occurred since the COVID-19 pandemic began. Despite ambitious goals for reducing suicides and significant fed- era…