Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Minglei Zhao · UNIVERSITY OF CHICAGO · 2024 · $410,000 — PROJECT SUMMARY / ABSTRACT Our lab focuses on structural and functional studies of molecular machines involved in chemical modifications of macromolecules. Naturally occurring chemical modifications of macromolecules play essential roles in all aspects of molecular biology, from transcriptional and…
Reid Spencer Alisch · ALBANY MEDICAL COLLEGE · 2024 · $778,634 — Project Summary: DNA 5'-C-phosphate-G-3' (CpG) methylation is a covalent epigenetic modification that regulates gene expression and is highly sensitive to age and environmental factors. Critically ill patients exhibit altered circulating blood DNA methylation profiles. We have recently reported a la…
SHAOYI JIANG · CORNELL UNIVERSITY · 2024 · $657,623 — PROJECT SUMMARY The immunogenicity of nanomaterials is directly related to their performance and toxicity. However, there is still a lack of systematic studies of how nanomaterials interact with the immune system. In this work, we will focus on the immunogenicity of lipid nanoparticles (LNPs). Vario…
Christian T Meyer · UNIVERSITY OF COLORADO · 2024 · $138,699 — Project Summary Biofilms are intrinsically drug-resistant. While the signaling pathways mediating resistance in biofilms are documented, only recently has the importance of electrophysiology in modifying gentamicin resistance come to light. However, the role of electrophysiology in biofilm formation…
Jean M Peccoud · COLORADO STATE UNIVERSITY · 2024 · $192,500 — Project Summary The unprecedented speed of COVID-19 vaccine development has demonstrated the value of vaccine platforms. In particular, mRNA vaccines proved surprisingly successful at eliciting a strong immune response while having a remarkable safety profile considering the novelty of this system. …
Justinn Barr · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $152,212 — PROJECT SUMMARY The airway epithelium serves as a barrier between the aerosol environment and the underlying submucosa. Inhaled air often carries noxious agents and pathogens that can injure the lung. Severe lung injury can lead to persistent inflammation, dysplastic repair, and permanent loss of g…
Latha Valluripalli Soorya · RUSH UNIVERSITY MEDICAL CENTER · 2024 · $806,933 — Project Summary/Abstract: The enormous impact of COVID-19 service disruptions on individuals with intellectual and developmental disabilities (IDDs) has highlighted the critically urgent need to increase access to mental and behavioral health services. Within IDD populations, genetic syndromes assoc…
Catherine Eichhorn · UNIVERSITY OF NEBRASKA LINCOLN · 2024 · $372,526 — ABSTRACT RNA is a structurally adaptive polymer that adopts complex tertiary structures and undergoes dramatic large- scale conformational changes to regulate cellular activity. Integral to RNA function is its remarkable plasticity and ability to structurally adapt in response to stimuli including s…
Jonathan G Terhorst · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $373,871 — Project Summary Technological breakthroughs such as next-generation sequencing have recently led to the creation of immense “BioBanks” featuring genomic information collected from hundreds of thousands of people, and the ongoing pandemic has resulted in an even more extreme repository containing ove…
Forrest Payne · SFC FLUIDICS, LLC · 2024 · $944,944 — Advanced Development of GeminiTM-DHAP Project Summary: The Specific Aim of this Direct to Phase II project is to develop a discrete, low-profile, dual hormone artificial pancreas device, the GeminiTM-DHAP, using SFC Fluidics' enabling microfluidic technologies to deliver both insulin and glucagon a…
William A. Carlezon · MCLEAN HOSPITAL · 2024 · $569,913 — SUMMARY This application is for competitive renewal of a grant that over its 20-year course has elucidated the ways in which the function of the transcription factor CREB and kappa-opioid receptor (KOR) systems within the nucleus accumbens (NAc) are changed by experience, including stress exposure, …
GEORGIA Doris TOMARAS · DUKE UNIVERSITY · 2024 · $4,307,324 — ABSTRACT_Overall Preventing HIV-1 acquisition and extinguishing virus replication is a key goal for vaccine and immunoprophylaxis strategies. Diverse antibody (Ab) Fc receptor (FcR)-mediated functions and multiple effector cell populations engage in vivo in a joint merger to thwart infection. An imp…
Lawrence James Purpura · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $192,260 — PROJECT SUMMARY/ABSTRACT: Rationale: The COVID-19 pandemic has affected over 42 million individuals in the United States and long-term complications are frequently reported, referred to as post-acute sequelae of SARS-CoV-2 (PASC). Even among survivors with mild acute illness, neurologic symptoms suc…
Cara Brook · UNIVERSITY OF CHICAGO · 2024 · $451,808 — The wide-reaching impacts of the COVID-19 pandemic highlight the extreme threat posed by the cross-species emergence of zoonotic pathogens. Bats (order: Chiroptera) are the natural reservoir hosts for the majority of the world’s most virulent zoonotic viruses, including Hendra and Nipah henipaviruse…
Jie Sun · UNIVERSITY OF VIRGINIA · 2024 · $662,044 — Project Summary Apart from the acute illness caused by SARS-CoV-2, it is now clear that a significant percentage of patients develop long-term conditions post COVID-19, including systemic and respiratory symptoms. Given the catastrophic spread of SARS-CoV-2 infection globally, there are many individ…
Saif Khairat · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $752,840 — Importance: Despite the emergence of virtual care (VC) programs during the COVID-19 pandemic, the sustainability of these programs is unknown because of concerns relating to health access in rural regions, future payment parity, effective integration into clinical workflows, and the misalignment o…
Stefan G Sarafianos · EMORY UNIVERSITY · 2024 · $678,703 — PROJECT SUMMARY Severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) cause severe diseases in humans (COVID- 19) that presents a major threat for global public health. Since it was first reported in 12/2019, COVID-19 has become a pandemic that continues to spread, with >246 million confirme…
HENRY M BLUMBERG · EMORY UNIVERSITY · 2024 · $298,480 — In 2023, tuberculosis (TB) has reemerged as the leading global cause of death from a single infectious agent, exceeding both HIV and COVID-19. TB remains an enormous public health problem in Ethiopia which is on the WHO list of high burden TB and TB/HIV countries and has increasing rates of drug-res…
Jamie Treadway Nomitch · UNIVERSITY OF WASHINGTON · 2024 · $89,188 — PROJECT SUMMARY/ABSTRACT Patients with chronic illness who develop acute respiratory failure face significant morbidity and mortality, with survivors often suffering serious physical and psychological sequelae. These patients have a critical need for palliative care. Palliative care is focused on im…
Gurumurthy Ramachandran · JOHNS HOPKINS UNIVERSITY · 2024 · $247,895 — PROJECT SUMMARY Many emerging technologies are becoming increasing ubiquitous in workplaces as well as non-occupational settings such as commercial and residential environments. While there are obvious benefits to these technologies, unintended exposures and risks from their use are becoming increas…