Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
MAUREEN C FERRAN · UNIVERSITY OF ROCHESTER · 2024 · $31,005 — Project Summary Fulfilling the promise of modern systems biology and grasping the underlying complexity of biological systems requires a foundation built upon the development of high-throughput functional genomic approaches capable of generating large datasets. Large scale sequencing efforts reveal …
Cody Carrell · SALUS DISCOVERY, LLC · 2024 · $300,000 — ABSTRACT Mycobacterium tuberculosis (TB) is a global threat to human health and accounts for 20% of adult deaths in low- income countries (~1.6 million deaths/year), yet only ~23% of new TB patients receive a WHO recommended nucleic acid test, while 37% receive tests with significantly lower sensiti…
John Tanner Wilson · VANDERBILT UNIVERSITY · 2024 · $346,493 — PROJECT SUMMARY Immune checkpoint blockade (ICB) is an immunotherapy that is revolutionizing cancer treatment, but is effective in a minority of patients. Across many cancer types, this can largely be ascribed to an insufficient number or function of tumor infiltrating T cells positioned for reactiv…
Hiroshi Nakagawa · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $462,811 — Project summary Esophageal stratified squamous epithelia comprise proliferative basal cells that undergo terminal differentiation in the suprabasal cell layer. This homeostatic proliferation-differentiation gradient is regulated by Notch signaling that is impaired in eosinophilic esophagitis (EoE), …
Soroush Tahmasebi · UNIVERSITY OF ILLINOIS AT CHICAGO · 2024 · $470,106 — SUMMARY mRNA translation, or protein synthesis, is a fundamental cellular process that can be dysregulated in several human diseases. Macrophages are heterogeneous populations that are present in most tissues and adopt tissue specific functions. The role of mRNA translational control in macrophages …
Rachel Karchin · JOHNS HOPKINS UNIVERSITY · 2024 · $633,077 — PROJECT SUMMARY Cancer sequencing projects have identified a very large number of DNA mutations whose importance in cancer is not yet understood. To better understand the impact of these mutations, our team has produced a software tool for computational analysis of cancer mutations that can analyze …
GINA G TURRIGIANO · BRANDEIS UNIVERSITY · 2024 · $564,875 — Project Summary Behavioral states such as sleep and wake profoundly affect the patterns of activity and neuromodulatory tone within neocortical circuits, but the function of these state changes on learning and experience-dependent plasticity remain controversial. It has been postulated that wake is …
Daniel V. LaBarbera · UNIVERSITY OF COLORADO DENVER · 2024 · $400,544 — Colorectal cancer (CRC) is the third most prevalent type of cancer diagnosed each year and CRC patients have the second highest mortality rate, worldwide. Standard of care treatments for CRC is largely ineffective against metastatic CRC (mCRC), which has an 11% 5-year overall survival rate. Aberrant…
Grace C. John-Stewart · UNIVERSITY OF WASHINGTON · 2024 · $755,327 — Abstract Antiretroviral treatment (ART) has dramatically improved outcomes for children living with HIV (CHIV) but poses challenges including poor adherence, side-effects, stigma, and drug resistance. An HIV cure would address these challenges but has been elusive due to the latent HIV reservoir th…
BINGHUI SHEN · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · 2024 · $316,742 — SUMMARY Cancer cells arise and progress due to accumulation of genetic and epigenetic alterations that contribute to cancer phenotypes. One potential cause of these alterations are DNA sequences that are “difficult-to-replicate” (DTR) and act as an endogenous source of replication stress. Across the…
Cenk Ayata · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $658,720 — PROJECT SUMMARY/ABSTRACT Despite intense research, we lack even the most basic understanding of how structural and functional changes in small vessel diseases of the brain (SVD) are linked to tissue oxygenation, whether this results in tissue hypoxia (O2 supply-demand mismatch), and how different mi…
Cheng-Ming Chuong · UNIVERSITY OF SOUTHERN CALIFORNIA · 2024 · $541,806 — Summary (30 lines) The long-term objective of our research is to understand the basic principles regulating the development and regeneration of skin and its appendages, and to apply this knowledge to regenerative medicine. Recent progress in stem cell biology has allowed the production of skin subst…
Ilija Dukovski · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · 2024 · $219,843 — Abstract Understanding the metabolic characteristics of tumors and their environments is crucial for elucidating the mechanisms of cancer development and for developing therapeutic strategies. Despite the increasing availability of 3D gene expression and other high-throughput data, a major unresolve…
Tomas M Mustelin · UNIVERSITY OF WASHINGTON · 2024 · $543,796 — Project Summary/Abstract The overall goal of our research is to elucidate the proximal molecular drivers and mechanisms of systemic lupus erythematosus (SLE) to enable the development of new and better therapies that target these processes but spare the broader immune system. This proposal will expl…
John Michael Stafford · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $181,470 — Project Summary This T35 grant application from the Vanderbilt Student Research and Training Program (SRTP) requests continued support for medical student research training in the areas of diabetes, obesity, digestive diseases, and kidney diseases. The SRTP started in 1975, and NIH-funded since 1980…
Michael R. Thomsen · UNIV OF ARKANSAS FOR MED SCIS · 2024 · $327,567 — PROJECT SUMMARY The Little Rock Green Schoolyard Initiative, with training and technical assistance from the National League of Cities and the Children and Nature Network, aims to transform the grounds of two elementary schools into nature-filled greenspaces. Using a community-schools model, several…
Kyung-An Han · UNIVERSITY OF TEXAS EL PASO · 2024 · $153,500 — Project Abstract The major goal of this research is to identify the genetic risk factors with functional significance to dementia in the model organism Drosophila melanogaster. The key aspect of dementia is age- dependent neurodegeneration that cripples executive functions (e.g. inhibitory control) …
Jing Wen · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $281,781 — It is estimated that around 15% to 40% of cancers spread to the central nervous system (CNS). The treatment of cancers with brain metastases, however, has been limited by the inefficient deliver of therapeutics to the CNS. We propose herein a novel strategy, which enables effective delivery of monoc…
Beth Ami Leeman-Markowski · VA MEDICAL CENTER · 2024 — Objective: The proposed study will determine the efficacy of methylphenidate (MPH) for the treatment of epilepsy-related attentional dysfunction. Epilepsy patients often have attention and other cognitive deficits, which can impair quality of life. The causes are typically multifactorial, including …
Eric Klann · NEW YORK UNIVERSITY · 2024 · $1,062,716 — Project Summary/Abstract Over the last 15 years, several laboratories, including my laboratory, have identified multiple signaling pathways that regulate translation via the translation initiation factors eIF4E and eIF2α during protein synthesis-dependent forms of long-lasting synaptic plasticity an…