Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Tsang-Wei Tu · HOWARD UNIVERSITY · 2024 · $377,376 — PROJECT SUMMARY Traumatic brain injury (TBI) represents a major public health concern in the United States. TBI can result in long-term neurological complications, including neurodegeneration, behavioral dysfunction, depression and epilepsy that seriously affect patient quality-of-life. Brain gluco…
Yanxun Xu · JOHNS HOPKINS UNIVERSITY · 2024 · $393,839 — Project Summary/Abstract The use of combination antiretroviral therapy (cART) has significantly reduced HIV-related morbidity and mortality. However, cART may exacerbate the central nervous system (CNS)-related adverse effects on mental health for people with HIV (PWH). These adverse effects may res…
Stephanie Hart Parade · MIRIAM HOSPITAL · 2024 · $359,024 — PROJECT SUMMAY / ABSTRACT There is increasing evidence for a profound and persistent impact of childhood stress and trauma on adverse behavioral and physical health outcomes across the lifespan. However, progress toward elucidating mechanisms of risk and novel prevention and intervention efforts to …
TRACI C GREEN · MIRIAM HOSPITAL · 2024 · $557,680 — PROJECT SUMMARY/ABSTRACT This is the fourth competitive renewal for T32DA013911 (HIV and Other Infectious Consequences of Substance Use) and seeks funding for Years 21-25. The program is led by multiple PIs: Dr. Timothy P. Flanigan (the PI for the past 20 years), who will direct mentoring and traini…
Torsten Brian Neilands · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $295,620 — ABSTRACT This application seeks continuation of funding for the Substance Use and HIV Prevention Research in Minority Communities program (SUHPR) at the University of California San Francisco (UCSF). SUHPR addresses the urgent need to promote clinical prevention research and reduce health disparitie…
MARGARITA ALEGRIA · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $941,888 — PROJECT SUMMARY Although minority elders represent the fastest growing segment of an aging US population, they have less access to mental health care and prevention of disability, lagging well behind non-Latino whites, and suffering significant disparities. Research suggests that a contributing fact…
Caryn Heldt · MICHIGAN TECHNOLOGICAL UNIVERSITY · 2024 · $186,408 — Project Summary AAV is a popular gene therapy vector because it has large tissue tropism and low toxicity. However, AAV is inefficient at packaging its genome, and this leaves many empty or partially full capsids that need to be removed in manufacturing. Empty capsids can increase the immunogenicity…
Maria Cecilia Caino · UNIVERSITY OF COLORADO DENVER · 2024 · $383,699 — PROJECT SUMMARY Mitochondria function is tightly regulated by a complex, intertwined machinery that dictates mitochondrial gross morphology, transport of organelles, inner membrane and cristae morphology, communication between adjacent mitochondria and contact with other organelles. These processes…
Eric Garr · JOHNS HOPKINS UNIVERSITY · 2024 · $84,364 — PROJECT SUMMARY Dopamine (DA) signaling in the ventral striatum has received considerable attention for its role in relapse and drug craving, both in rodent models of addiction and in humans. A popular belief is that dopamine neurons in the ventral tegmental area (VTA) communicate a prediction error…
Kangho Kim · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 2024 · $374,400 — ABSTRACT Bile acids (BAs) have recently emerged as metabolic regulators in obesity and type 2 diabetes. We discovered that the BA overload in farnesoid X receptor (FXR) and small heterodimer partner (SHP) double knockout mice unexpectedly exerts anti-obesity and anti-diabetic effects. Intriguingly, …
GERALD SCHATTEN · MAGEE-WOMEN'S RES INST AND FOUNDATION · 2024 · $366,824 — PROJECT SUMMARY This application, responsive to PAR-17-290, seeks R25 funding for “Advancing Native American Diversity in Aging Research through Undergraduate Education.” By offering annual courses and mentored research—along with online virtual education and mentoring during this COVID-19 pandemic—…
Kallol Gupta · YALE UNIVERSITY · 2024 · $351,750 — Abstract In the crowded milieu of the membrane, membrane proteins, with other soluble and membrane-associated proteins, and lipids form a large number of dynamic and transient protein complexes that in turn govern cellular physiology. There is also mounting evidence that both independent membrane pr…
Aryana Razmara · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $41,568 — PROJECT SUMMARY/ABSTRACT Although immunotherapy, especially immune checkpoint inhibition (ICI) with PD-1/PD-L1 inhibitors, has rapidly become the fourth pillar in cancer therapy with increasing breakthrough advances, barriers still exist to its success. Given their ability to rapidly exert their cyt…
Eli Rothenberg · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $533,862 — V(D)J recombination lies at the heart of antigen receptor diversity and adaptive immunity. The RAG complex (RAG), which includes RAG1, RAG2 and HMGB1, initiates this critical process by binding recombination signal sequences (RSSs) and creating DNA double-stranded breaks (DSBs). The resulting breaks…
Molly Cuddy Sutherland · UNIVERSITY OF DELAWARE · 2024 · $400,000 — Project Summary Cytochromes c are highly conserved heme proteins that function in electron transport chains for cellular functions such as respiration, photosynthesis and detoxification. The ability of prokaryotes to survive and thrive in diverse, often hostile environments is a direct result of the…
Manolis Kellis · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2024 · $1,135,203 — Abstract Alzheimer’s disease (AD) is a devastating neurodegenerative disorder that leads to dramatic effects on the affected individuals and their families. While the characterization of the genetic contribution to AD and underlying molecular mechanisms have advanced the understanding of the disease…
Payman Zamani · UNIVERSITY OF PENNSYLVANIA · 2024 · $770,206 — SUMMARY: Heart Failure with Preserved Ejection Fraction (HFpEF) is on pace to become the dominant form of heart failure, yet we have no treatments to offer patients. Our preliminary data suggest that abnormalities in skeletal muscle oxidative phosphorylation capacity (SM OxPhos) may contribute to ex…
Christos Davatzikos · UNIVERSITY OF PENNSYLVANIA · 2024 · $601,392 — Abstract The current state of magnetic resonance imaging (MRI) methods in neurooncology offers great potential for providing rich characterizations of structural, physiological, and metabolic character- istics of brain tumors, especially gliomas, which are complex and highly heterogeneous cancers. G…
Guanghua Xiao · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $356,526 — Project Summary The location, timing and abundance of mRNA and proteins within a tissue underlie the basic molecular mechanisms of cell functions and physiological and pathological developments. For example, the study of expression of thousands of genes simultaneously at different locations could re…
LAWRENCE S PHILLIPS · EMORY UNIVERSITY · 2024 · $363,824 — We will test the hypothesis that the typical worsening of hyperglycemia in type 2 diabetes (DM) will be reduced by keeping glucose normal compared to usual care. Progression of hyperglycemia is mediated by loss of β-cell function, which will be mitigated by normalizing glucose, reducing the “excito…