Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
MARGARET Rita KARAGAS · DARTMOUTH COLLEGE · 2024 · $1,205,733 — ABSTRACT The field of epidemiology has gained increasing prominence in the research community and became a household word in 2020. Epidemiology provides the tools to uncover the underlying causes of human illness and to, in turn, inform clinical practice and preventive strategies, advise policy and …
CHRISTOPHER Martin HAMMELL · COLD SPRING HARBOR LABORATORY · 2024 · $415,296 — Project Abstract: Developmental gene regulation is a multidimensional problem where signals converge to generate patterns of transcription at the proper location (spatial regulation) and correct time (temporal regulation). An equally important feature of this regulatory process involves generating t…
Joseph M Braun · BROWN UNIVERSITY · 2024 · $10,000 — ABSTRACT The International Society for Environmental Epidemiology (ISEE) is the preeminent scientific society focused on relationships between environmental agents and human health. The annual conference provides a critical forum for the exchange of ideas and development of potential solutions to pr…
Benjamin Izar · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $657,805 — Brain metastasis (BM) occurs in up to 40% of patients with advanced cancers, most frequently arising from non-small cell lung cancer (NSCLC). Patients with BM frequently suffer from debilitating symptoms, have worse response rates to modern cancer therapies and are excluded from most clinical trials…
SALLY Choate KENT · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · 2024 · $751,132 — PROJECT SUMMARY/ABSTRACT (30 lines or less) The premise for the proposed research stems from precedence in other diseases, such as cancer, cardiovascular, neurodegenerative, and most relevant to the current proposal, autoimmune diseases, in which extracellular vesicles (EVs) play a role in the patho…
JAMES T BENNETT · SEATTLE CHILDREN'S HOSPITAL · 2024 · $2,750,000 — PROJECT SUMMARY Precision genomic medicine depends on a complete understanding of all forms of genetic variation in normal individuals. However, current approaches for studying genetic variation in humans have yielded an incomplete snapshot of somatic variation and its contribution to health and dis…
MARIA HATZOGLOU · CASE WESTERN RESERVE UNIVERSITY · 2024 · $650,207 — The ability to adapt to environmental challenges is critical for cellular and organismal function. A frequent challenge is dehydration which increases osmotic pressure on the cells causing water loss and cell shrinkage. Cells respond by accumulating organic osmolytes to accommodate decreases in cell…
MARK Ethan FEINBERG · PENNSYLVANIA STATE UNIVERSITY, THE · 2024 · $684,867 — ABSTRACT Although we are not yet in a position to estimate the total collateral damage to health and society due to the COVID-19 pandemic, widespread increases in stress, financial strain, depression/anxiety, family conflict, and social isolation during the pandemic may each have large and cumulativ…
Elizabeth Marie Viglianti · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $170,894 — Project Summary Candidate’s Long-Term Career Goal: To become an independently funded physician-scientist with a clinical expertise in persistent critical illness and bioethics with a methodological expertise in longitudinal surveys. Clinical Problem: Patients with prolonged ICU stays are costly, inc…
TIMOTHY J CARDOZO · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $228,825 — Project Summary An HIV vaccine remains a critical and as yet unrealized asset in the 40-year fight against the HIV/AIDS pandemic. New insights towards achieving vaccine protection from HIV acquisition may be gained by a comparative case study of COVID-19 vaccines, which achieved nearly 100% efficacy…
Rahul Aggarwal · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $611,272 — The recent clinical success of inhibitors against immune checkpoint proteins (e.g. CTLA-4, PD-L1), which are thought to stimulate T cell responses against tumors, has revolutionized cancer therapy. Yet even among patients with high tumor mutational burden, only approximately 20-30% of patients achie…
Alexander Vladimirovich Ovechkin · UNIVERSITY OF LOUISVILLE · 2024 · $741,227 — Project Summary/Abstract Respiratory motor control deficit is the leading cause of morbidity and mortality in patients with spinal cord injury. The long-term goal of this research is to develop a rehabilitation strategy for respiration in patients with spinal cord injury as a standard of care. Our p…
Jenna Bergmann · YALE UNIVERSITY · 2024 · $33,958 — Despite the high prevalence of pregnancy loss during the early post-implantation period, a detailed understanding of cell and molecular workings at this stage of development remains elusive. During this period, specification of the principal lineages of the future body occurs at the gastrulation sta…
Camille Jaime · JOHNS HOPKINS UNIVERSITY · 2024 · $48,974 — Immune checkpoint inhibitors (ICIs) have transformed cancer immunotherapy. ICIs optimize T cell activation and recognition to kill tumor cells. However, ICI treatments may also activate self- reactive immune cells. Cancer patients may then experience immune-related adverse events (irAEs), which can …
JOHANNES W HELL · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $113,064 — Abstract Supplement to Parent Grant Dysregulation of Cav1.2 by beta amyloid peptide L-type Ca2+ channels (LTCC) are key regulators of gene transcription, neuronal excitability, and synaptic functions. Cav1.2 is the prevalent LTCC in brain (Hell et al., 1993, JCB 123, 949-962). Chronically increased …
Diana Chin · CASE WESTERN RESERVE UNIVERSITY · 2024 · $53,974 — PROJECT SUMMARY Osteosarcoma (OS) metastasis is the leading driver of mortality, but there are no therapies tailored to metastatic disease. Despite the development of numerous treatment modalities targeting the primary tumor, 40% of pa- tients still die from metastatic progression. Developing target…
Youngsun Kong · UNIVERSITY OF CONNECTICUT STORRS · 2024 · $80,556 — Project Summary We propose to diagnose and differentiate dental pain from stress using a wearable electrodermal activity (EDA) device. Dental caries is one of the major causes of endodontic infection in the pulp or soft tissues of the tooth, causing hypersensitivity, severe pain, and even death. It …
Joanna Eskander Hoh · UNIVERSITY OF DELAWARE · 2024 · $46,796 — PROJECT SUMMARY/ABSTRACT A recent emphasis in stroke rehabilitation research focuses on capturing how an individual’s paretic arm capacity (what one can do when prompted in the clinic) compares to an individual’s daily performance (what one does spontaneously in the real-world). Historically, motor …
Callen M Maupin · UNIVERSITY OF MINNESOTA · 2024 · $47,009 — PROJECT SUMMARY Parkinson’s disease (PD) is a prominent neurodegenerative disease with over 90,000 cases being diagnosed annually. Little is known about the pathogenesis of abnormal trunk posturing/impaired postural control in PD. Trunk postural control is particularly problematic during both standi…
Arianna Neal Davis · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $50,374 — PROJECT SUMMARY/ABSTRACT Social interaction strongly influences both momentary mood and general mental health. Indeed, social isolation during the recent pandemic caused record-high levels of mood symptoms in many individuals around the world. This relationship between social interaction and mood ha…