Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Amelie Collins · CINCINNATI CHILDRENS HOSP MED CTR · 2024 · $414,026 — PROJECT SUMMARY/ABSTRACT Maternal infections during pregnancy lead to adverse outcomes for the offspring, including short-term outcomes such as intrauterine fetal demise, preterm delivery and neonatal sepsis, and long-term sequelae such as neurodevelopmental impairment. A key factor contributing to…
Bassel El-Rayes · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2024 · $590,094 — SUMMARY/ABSTRACT Cancer associated fibroblasts and pancreatic stellate cells (PSC/CAF) and abnormal tumor blood vessels are two major factors that contribute to treatment failure. PSC/CAF contribute to the collagen-rich extracellular matrix (ECM) which impairs drug delivery, promotes cancer cell sur…
Jennifer Marie Traver · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $40,441 — PROJECT SUMMARY Substance use is one of the most commonly occurring health risk behaviors and has been unambiguously linked to numerous negative outcomes (e.g., Stellern et al., 2023, Planell-Ripoll et al., 2019). These far- reaching public health issues have impelled substantial growth in the theor…
Steven Michael Zwick · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $76,984 — A significant fraction of asthma patients face challenges in managing their symptoms with available therapies. Uncovering new drug targets holds the promise of alleviating their suffering and improving their quality of life. Anticholinergics, which bind and inhibit muscarinic acetylcholine receptors…
Rebecca K Davidson · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $73,828 — PROJECT SUMMARY This F32 proposal describes a comprehensive training and mentorship program for Dr. Rebecca Davidson, a postdoctoral research fellow in the Department of Internal Medicine at the University of Michigan. Dr. Davidson will participate in a rigorous training plan, guided by their mentor…
Anderson Ross Frank · FRED HUTCHINSON CANCER CENTER · 2024 · $76,828 — Project Summary/Abstract An organism’s ability to grow, develop, and reproduce are some of the defining characteristics of life. Central to growth and reproduction of organisms ranging from single-celled baker’s yeast to humans is the ability of a cell to replicate its genome and accurately divide t…
Luuli Tran · UNIVERSITY OF COLORADO DENVER · 2024 · $40,313 — PROJECT SUMMARY Oligodendrocytes are glial cells in the central nervous system that form myelin, which are critical for the proper formation and function of neural circuits. During brain development, neural progenitor cells first give rise to excitatory neurons before gradually transitioning to the …
Maxwell Clark Coyle · HARVARD UNIVERSITY · 2024 · $73,408 — PROJECT SUMMARY Multicellular nervous systems allow animals to sense and respond to their specific environments. Yet animals evolved from unicellular eukaryotes, in which a single cell must carry out signal transduction from sensation to behavior. Therefore, understanding how unicellular eukaryotes …
Yareliz Diaz · BOSTON UNIVERSITY MEDICAL CAMPUS · 2024 · $46,241 — Project Summary/Abstract: Over 130,000 Puerto Ricans have migrated to the US since Hurricane María in 2017. They comprise a growing population of individuals and families who migrate due to threats on their life, safety, or health (henceforth referred to as crisis migrants). The number of crisis mig…
Ayma Malik · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · 2024 · $44,426 — PROJECT SUMMARY/ABSTRACT Opioids derived from opium are amid the oldest medications dating back to the 1800s, originally used for gastrointestinal distress and now are among the most effective treatments for pain management. It wasn’t until the mid-1800s that the abuse potential for opioids was evid…
YONGLING ZHU · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $400,000 — Project Summary/Abstract The long-term goal of this research is to understand visual processing in the inner plexiform layer of the retina. More immediately, the research serves to provide genetic access to distinct glycinergic amacrine cell types for functional characterization and to understand ho…
Aakash Basu · YALE UNIVERSITY · 2024 · $48,974 — PROJECT SUMMARY Individuals must predict threats in the environment in order to survive. However, maladaptive threat computation processes can lead to psychiatric disorders such as post-traumatic stress disorder. For threat predictions to be adaptive, they must be temporally accurate and capable of…
Sanna Darvish · UNIVERSITY OF COLORADO · 2024 · $42,030 — PROJECT SUMMARY/ABSTRACT The purpose of this Ruth L. Kirschstein National Research Service Award is to provide support for Ms. Sanna Darvish, a PhD student in Dr. Douglas Seals’ laboratory at the University of Colorado Boulder, to conduct research that will prepare her to become an independent inves…
Joy Jiang · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $49,474 — PROJECT SUMMARY Sudden cardiac arrest (SCA) is a leading cause of cardiovascular deaths in the United States, with significant disparities in survival rates among different racial and ethnic groups. Despite its prevalence, predicting risk of SCA is challenging due to limited methods for early detect…
Rahaf Shishani · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $41,972 — PROJECT SUMMARY Dysregulation of pancreatic islet function is a hallmark of type 2 diabetes mellitus (T2DM) progression. Thus, understanding the exact mechanisms by which islet function can be preserved and regulated is crucial. It is increasingly evident that α-cells play an important role in the p…
Courtney N. Slater · UNIVERSITY OF PENNSYLVANIA · 2024 · $48,974 — Project Summary/Abstract: The purpose of this individual National Research Service Award (NRSA) application is to provide the applicant with rigorous research training to develop into an independent investigator focusing on barriers and facilitators to healthy infant feeding practices. This award wi…
Jose Enrique Pietri · UNIVERSITY OF SOUTH DAKOTA · 2024 · $1 — PROJECT SUMMARY Salmonella enterica serovar Typhimurium is a widespread human enteric pathogen that has a broad range of animal hosts and environmental reservoirs. Meanwhile, the German cockroach, Blattella germanica, is the most common pestiferous cockroach species in human environments. B. germani…
John Andrew Pospisilik · VAN ANDEL RESEARCH INSTITUTE · 2024 · $698,646 — PROJECT SUMMARY Type 2 diabetes (T2D) is a disease that results from relative pancreatic β-cell dysfunction, and affects >400 million people. We (Rutter) previously identified functional β-cell subsets based upon analysis of real-time Ca2+ responses and cell-cell connectivity. A “βLEADER” population…
Mariah J Wulf · DREXEL UNIVERSITY · 2024 · $48,974 — PROJECT SUMMARY Following spinal cord injury (SCI) at or above thoracic level 6 (T6), descending supraspinal control over the spinal neurons associated with sympathetic function is severed. This, along with plasticity within these neurons themselves, results in exaggerated sympathetic reflexes know…
Erica Waters · UNIVERSITY OF PENNSYLVANIA · 2024 · $48,974 — PROJECT SUMMARY/ABSTRACT Disabilities, including those due to a stroke, are common among older adults worldwide, affecting about 36% of adults 65 and older in the USA.1 As the world’s population ages, the need for effective, affordable, accessible rehabilitation will increase. This need is particula…