Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Luisa Cervantes Barragan · EMORY UNIVERSITY · 2024 · $5,596 — Summary Crohn’s disease and Ulcerative colitis collectively referred as inflammatory bowel disease (IBD) are diseases in which an aberrant intestinal immune response leads to chronic inflammation. IBD affects an estimated 1.5 million Americans, 2.2 million people in Europe and hundreds of thousands …
Scott A. Handley · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $819,227 — PROJECT SUMMARY The majority of HIV worldwide is transmitted following heterosexual intercourse and women are twice as likely to contract HIV from heterosexual sex than men. Mucosal tissues in the female genital tract (FGT) therefore represent the frontline of transmission since they are the site at…
Sonia Mediouni Jablonski · UNIVERSITY OF FLORIDA · 2024 · $289,800 — ABSTRACT The persistence of latently infected memory CD4+ T cells releasing a low-level trickling of viral RNAs and proteins in people living with HIV (PLWH) on antiretroviral therapy (ART) provides a strong rationale for the development of cure strategies. HIV functional cure approaches are being …
Holly Rockweiler · MADORRA, INC. · 2024 · $1,514,498 — Abstract Decreases in endogenous estrogen production during and after menopause or cancer treatment is associated with decreased lubrication and thinning of the vaginal tissue, making it sensitive, friable, and inelastic. Vulvovaginal Atrophy (VVA) leads to pain during sex, which contributes to lowe…
CONNIE L CELUM · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $1,628,180 — Sexually transmitted infections (STIs) continue to rise in the US and globally, disproportionately affecting men who have sex with men (MSM) and transgender women (TW), with the highest rates in people of color, living with HIV (PLWH) and those ≤30 years of age. Doxycycline taken within 72 hours aft…
Lauren C. Zalla · JOHNS HOPKINS UNIVERSITY · 2024 · $126,387 — PROJECT SUMMARY The purpose of this K99/R00 Pathway to Independence Award is to support Dr. Lauren Zalla as she transitions into an independent research career focused on studying the modifiable place-based determinants of health among people with HIV. The K99 Phase of the award period will be compl…
Rami Kantor · MIRIAM HOSPITAL · 2024 · $645,900 — HIV Drug Resistance in the New ART Era in Kenya Rami Kantor, MD SUMMARY Since the emergence of resistance to zidovudine in the late 1980’s, we have been in a race: an HIV drug is developed and used, followed by the inevitable emergence of viral resistance to it, another drug is developed and used, a…
Mary Rose D'Angelo · STATE UNIVERSITY OF NEW YORK AT BUFFALO · 2024 · $36,070 — PROJECT SUMMARY/ABSTRACT Human Immunodeficiency Virus 1 (HIV-1) is the causative agent behind acquired immunodeficiency syndrome (AIDS) and the resulting pandemic. Antiretroviral therapies are effective in controlling infections, however patients require lifelong treatment and can have severe side e…
Catherine Lima Chantre · YALE UNIVERSITY · 2024 · $51,974 — PROJECT SUMMARY Exposure to traumatic events is associated with increased HIV risk in adults, however for young, forcibly displaced persons this relationship is less clear. An insurgency in northern Mozambique has internally displaced >1 million inhabitants from Cabo Delgado province. Moreover, Moza…
Miranda Hill · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $183,331 — PROJECT SUMMARY/ABSTRACT Global health agencies have identified migration as a common and key determinant of health and well-being, with women disproportionately vulnerable to higher HIV risk and poorer health service access and utilization. African American women are among the key populations harde…
Michael W. Deininger · VERSITI BLOOD HEALTH, INC. · 2024 · $352,688 — PROJECT SUMMARY TARGETING THE METABOLIC REGULATOR SIRT5 IN ACUTE MYELOID LEUKEMIA. AML is an aggressive hematologic malignancy with <30% long-term survival. The current therapy standard, chemotherapy alone or combined with allogeneic stem cell transplant, has not changed for decades. Despite initial…
Jeffrey Nicholas Myers · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2024 · $238,959 — Overall SUMMARY Head and neck squamous cell carcinoma (HNSCC) remains a leading cause of cancer deaths worldwide with ~500,000 cases/year. Cisplatin is the gold standard systemic agent for HNSCC. Cisplatin resistance, both intrinsic and acquired, has been described in preclinical models and is freq…
Tristan Geiller · YALE UNIVERSITY · 2024 · $248,999 — Project Summary The research proposed in the R00 phase will be conducted in the Department of Neuroscience at Yale University School of Medicine. The project description has been updated to reflect changes in the research from the original submission. The ability to remember past personal happenings…
Heather R Burkin · UNIVERSITY OF NEVADA RENO · 2024 · $4,229 — PROJECT SUMMARY Matrix Metalloproteinases 2 and Metalloproteinase 9 (MMP2/9) play active roles in a variety of cellular responses, including the regulation of uterine contraction. The underlying molecular mechanisms driving these effects are currently unknown. The overall objective of the parent pr…
Emmanouil Tsamis · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $248,207 — Project Summary / Abstract There is no single (litmus) test to confirm the presence or the progression of glaucoma, a group of optic neuropathies. Therefore, clinicians rely on characteristic changes on structural and functional tests to diagnose and monitor the disease. There is increasing evidence…
Carrie Lynn Esopenko · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $100,000 — ABSTRACT – no change from parent grant Intimate partner violence (IPV), the physical violence, sexual violence, psychological aggression, or stalking by a current or former intimate partner, is a significant public health concern affecting approximately 10 million people in the United States annuall…
BERNICE E MORROW · UNIVERSITY OF CHICAGO · 2024 · $579,364 — Project Summary Cardiac outflow tract (OFT) defects have an estimated prevalence of 1-2 in 1,000 live births. The 22q11.2 deletion syndrome or 22q11.2DS is one of the most frequent genetic causes of cardiac OFT defects. A total of 60% of patients with 22q11.2DS have congenital heart disease that ran…
Michael R Betts · UNIVERSITY OF PENNSYLVANIA · 2024 · $694,301 — Increasing efforts are being made to understand whether early intervention after HIV-1 infection can enable long- term viral control and reduction of the viral reservoir through the preservation of HIV-1-specific immune responses. Recently, the pioneering eCLEAR phase 1b/2a clinical trial led by MPI…
Jarrod Mousa · FLORIDA STATE UNIVERSITY · 2024 · $685,212 — Streptococcus pneumoniae is a leading infectious pathogen, causing pneumonia, bacteremia, meningitis, acute otitis media, and nearly one million deaths worldwide each year. S. pneumoniae can be carried in the nasopharynx asymptomatically, which contributes to pathogen spread, as pneumococcal carriag…
JACOB E FRIEDMAN · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · 2024 · $200,680 — Project Summary/Abstract Indigenous mothers (those who self-identify as American Indian, Alaskan Native, or Native American) experience the highest rates of maternal mortality and morbidity (MMM) in the U.S. Structural, social, and biobehavioral factors driving these inequities such as food insecuri…