Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
JAMES R FUCHS · UNIVERSITY OF COLORADO DENVER · 2024 · $847,141 — Abstract New therapeutic options are needed to treat people infected with multi-drug resistant HIV-1 phenotypes. Here we propose to both investigate and exploit the non-catalytic, essential function of HIV-1 integrase (IN) during virion morphogenesis as a novel therapeutic target. Our highly collabo…
Cesar Torres Luna · LYNTHERA CORPORATION · 2024 · $55,000 — PROJECT SUMMARY The proposed I-Corps project is based on a predicate SBIR Phase I award for the development of a long-lasting, sustained release of NLX product using a novel system of a pH/temperature-sensitive hydrogel embedded with NLX-encapsulated solid lipid nanoparticles (SLNs), employed in an …
RENATA A SANDERS · CHILDREN'S HOSP OF PHILADELPHIA · 2024 · $674,186 — Project Summary/Abstract To end the HIV epidemic, we need integrated care models that address HIV and PrEP care, and co-existing substance use (SU) disorders that disrupt uptake and consistent use of effective interventions. The overarching goal of this R01 proposal is to conduct a randomized contro…
Sabrina Diano · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $98,412 — Our recent studies have demonstrated that mitochondrial fission is tightly connected to lipid metabolism and more specifically, that mitochondrial fission is an inherent element in oxidation of long chain fatty acids by the orexigenic AgRP neurons (Jin et al., 2021). Intriguingly, while mitochondria…
Mon-Wei Yu · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $75,600 — Project Summary: Chronic kidney disease (CKD) continues to be a significant factor in global morbidity and mortality. Patients experiencing repetitive acute kidney injury (AKI) are predisposed to CKD. Despite discoveries of novel biomarkers and increasing awareness of kidney health, the prevalence o…
Laura Marie Nally · YALE UNIVERSITY · 2024 · $75,599 — PROJECT SUMMARY/ABSTRACT Thirty years of follow up data from two landmark trials (DCCT/EDIC) demonstrates that intensive insulin management to achieve near-normal blood glucose levels decreases the risk of retinopathy, neuropathy, and nephropathy for individuals with type 1 diabetes (T1D).1,2 Yet, …
Erika Luz Gustafson · UNIVERSITY OF ILLINOIS AT CHICAGO · 2024 · $177,012 — PROJECT SUMMARY/ABSTRACT This K08 proposal will address a critical need for evaluating and understanding the implementation of community health worker (CHW) mental health models to reduce treatment disparities for underserved groups, specifically, Spanish-speaking Latine parents. The Common Elements…
JOAN M HEVEL · UTAH STATE UNIVERSITY · 2024 · $90,241 — PROJECT SUMMARY Protein arginine methylation catalyzed by Protein arginine methyltransferase 1 (PRMT1) is of intense current interest as an anti-cancer therapeutic target, as well as a mediator of lung, kidney, neurodegenerative and cardiovascular pathologies. To date, the majority of studies charac…
Audrey Weber · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2024 · $40,708 — Neurofibrillary tangles (NFTs) of the microtubule-associated protein tau are a universal feature of the aging brain. The extent of tau pathology throughout the brain correlates with both synapse loss and severity of cognitive impairment in age-related tauopathies. The ability to maintain cognitive f…
Cory R Weissman · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $197,576 — PROJECT SUMMARY / ABSTRACT Over 700,000 individuals across the world die by suicide annually. Most individuals who complete suicide suffer from psychiatric illness, of which major depressive disorder (MDD) is most common. Suicidal ideation (SI) is more prevalent in individuals with treatment-resista…
Alex J. Vecchio · STATE UNIVERSITY OF NEW YORK AT BUFFALO · 2024 · $159,785 — Project Summary Tight junctions (TJs) at the boundaries of endothelial and epithelial cells are critical in the development and function of vertebrates because they enable these tissues to separate, protect, and shape external epidermis and limbs and internal organs and glands. TJs regulate molecula…
Keith B Neeves · UNIVERSITY OF COLORADO DENVER · 2024 · $105,144 — This NIH Diversity, Equity, Inclusion, and Accessibility (DEIA) supplement seeks to enhance the parent grant by focusing on mentor training and development, ensuring that the next generation of bioengineering scholars are equipped with the skills necessary for postgraduate success in bioengineering,…
KELLY J HUNT · RALPH H JOHNSON VA MEDICAL CENTER · 2024 — Anticipated Impacts on Veterans Health Care: This project will put forth a comprehensive geospatial framework to address the VA Blueprint for Excellence Strategy 3: Leverage information technologies, analytics, and models of healthcare to optimize individual well-being and population health outcomes…
Jason Ken Hou · MICHAEL E DEBAKEY VA MEDICAL CENTER · 2024 — Background: Biologic medications (biologics) are highly effective for diseases of the immune system, cancers, and other conditions; however, their high expense is a barrier to care and a burden to the healthcare system. Biologics cannot be exactly copied as “generic” medications. Biosimilars- simila…
Negin Forouzesh · CALIFORNIA STATE UNIVERSITY LOS ANGELES · 2024 · $24,632 — Project Summary/Abstract High performance computing (HPC) has become an indispensable resource for scientific research in diverse fields including deep learning, bioinformatics, and molecular simulation. In the parent award (Grant No.: 1R16GM146633), Dr. Negin Forouzesh (PI) proposed to design, dev…
Koyal Garg · SAINT LOUIS UNIVERSITY · 2024 · $98,046 — ABSTRACT Skeletal muscle possesses a remarkable ability to repair and regenerate following moderately severe injuries (e.g., tears, sprains, etc.). However, following a substantial loss of muscle tissue (>20%), termed as a volumetric muscle loss (VML), the muscle tissue is unable to repair and rege…
Bruce Alan Knutson · UPSTATE MEDICAL UNIVERSITY · 2024 · $122,450 — Project Summary Eukaryotic RNA polymerase I (Pol I) transcribes ribosomal RNA, a key component of ribosomes. Pol I transcription accounts for the majority of the total RNA in cells, and its upregulation in human cells is a hallmark of cancer while its downregulation is a hallmark of several developm…
VALENTIN DRAGOI · METHODIST HOSPITAL RESEARCH INSTITUTE · 2024 · $475,319 — PROJECT SUMMARY A critical issue for understanding sleep function is whether and how it impacts the accuracy of neuronal network computations to improve behavioral performance. Indeed, studies over the past several decades have shown that even brief periods of rest are correlated with subsequent imp…
Debswapna Bhattacharya · VIRGINIA POLYTECHNIC INST AND ST UNIV · 2024 · $240,509 — PROJECT SUMMARY/ABSTRACT: This supplement aims to acquire a Dell high-performance computing (HPC) server with 8 NVIDIA H100 Graphics Processing Units (GPUs) to supercharge foundational deep learning method development for scalable and accurate prediction of protein structures, paving the way to geno…
Adi D Dubash · FURMAN UNIVERSITY · 2024 · $99,130 — PROJECT SUMMARY The desmosome cell-cell adhesion complex plays an important role in the maintenance of tissue structure and integrity in response to mechanical stress. In addition to this central adhesive role, desmosomal proteins also coordinate multiple processes such as proliferation, apoptosis, …