Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Kelly L Whiteford · UNIVERSITY OF MINNESOTA · 2024 · $67,284 — Modulations in frequency and amplitude are fundamental attributes of natural sounds. Frequency modulation (FM) is essential for sound segregation, talker recognition, and the tracking of prosody in speech and music. FM sensitivity degrades with normal aging and hearing loss, thereby restricting the …
Melissa Renee Dvorsky · CHILDREN'S RESEARCH INSTITUTE · 2024 · $161,412 — PROJECT SUMMARY/ABSTRACT While evidence-based behavioral treatments for adolescents with Attention-Deficit/Hyperactivity Disorder (ADHD) are well-established, these interventions most often fail to generalize across settings and are associated with intervention effects that dissipate over time. The …
EVAN S DENERIS · CASE WESTERN RESERVE UNIVERSITY · 2024 · $440,108 — Precise spatiotemporal control of gene expression is crucial throughout life for maturation of postmitotic neuronal function and preservation of brain health. Although continuously expressed neuronal transcription factors termed terminal selectors, such as Pet1 and Lxm1b, are key regulators of gene …
MARIA A. KUKURUZINSKA · BOSTON UNIVERSITY MEDICAL CAMPUS · 2024 · $633,640 — Head and neck squamous cell carcinoma (HNSCC) is a devastating malignancy associated with severe morbidity, high mortality and limited treatment options. The main subsite of HNSCC is the oral cavity, where the disease presents primarily as tobacco- and alcohol-associated HPV(-) oral squamous cell ca…
Sangamesh Gurappa Kumbar · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · 2024 · $430,763 — Peripheral nerve injuries (PNI) affect millions of people in the US, and PNI with large gaps require surgical repair. Although biological and synthetic grafts are widely used to repair PNI with large gaps, they both can suffer from suboptimal clinical outcomes. Autografts are the gold standard treat…
Dionysios Kavalieratos · EMORY UNIVERSITY · 2024 · $590,820 — Project Summary Therapeutic advances have doubled life expectancy for many people living with cystic fibrosis (PLWCF), yet multisystem symptom burden (e.g., pain, dyspnea, fatigue) continues to impair quality of life. Evidence also suggests that quality of life and mortality in CF are influenced by …
NAGI G AYAD · GEORGETOWN UNIVERSITY · 2024 · $234,000 — PROJECT SUMMARY Despite considerable advances in identifying genetic and epigenetic abnormalities in medulloblastoma, many patients succumb to the disease. In addition, patients who respond to traditional therapy suffer from cognitive and intellectual deficits. Therefore, there is a dire need to ide…
Jorge Alvaro Gonzalez-Martinez · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $618,013 — SUMMARY Motivation: Stroke is one of the leading causes of permanent motor disability in the United States, affecting approximately 795,000 people a year. Despite the large population size of affected individuals, intense physical therapy remains the only significant intervention with limited impact…
Ethan Lippmann · VANDERBILT UNIVERSITY · 2024 · $443,089 — Summary statement Robust model systems are essential for understanding human disease. While Alzheimer’s disease can be studied using in vivo models that have become more representative in recent years (e.g. by introducing natural genetic diversity and humanized APOE variants into existing Alzheimer’…
Li Gan · AETON THERAPEUTICS, INC. · 2024 · $499,911 — Abstract Alzheimer’s disease (AD) is one of the most common in the United States, as the sixth leading cause of death among those 65 or older, and impairing the quality of life for 6.2 million adults as of late 2020. As the population ages, the number of AD patients is expected to grow to over 13.8 …
Kinneret Rand · SEETRUE TECHNOLOGY, LLC · 2024 · $296,043 — PROJECT SUMMARY Biomedical applications in both research and clinical settings rely on microinjection protocols that require using a hollow microcapillary needle to deliver foreign substances (e.g., nucleic acids, proteins, viruses, cells, and nanoparticles) directly into biological targets (e.g., c…
JUSTIN L SONNENBURG · STANFORD UNIVERSITY · 2024 · $427,265 — The human gastrointestinal tract houses a complex gut microbiota, or microbiome that is tightly linked with numerous inflammatory and metabolic diseases. The gut microbiota influences local and systemic immune responses, chronic low-grade inflammation, and plays an important role in the pathogenesis…
Jennifer Prescher · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $675,594 — ABSTRACT Chimeric antigen receptor (CAR) T-cells are a revolutionary cancer treatment, with the particular benefit of generating memory T-cells that can last for years and suppress cancer relapse. CAR-expressing CD8+ T-cells have been shown to cure leukemia and other cancers in clinical trials with …
CORINNA DARIAN-SMITH · STANFORD UNIVERSITY · 2024 · $591,219 — Project Summary/Abstract The toll of spinal cord injury on people and society is substantial, and particularly so when hand function is impaired and independence lost. We use well defined spinal cord injury (SCI) models in nonhuman primates and rodents to delineate the responses of major ascending a…
Yingchang Lu · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $714,892 — Over 40% of adults are obese in the US. Although reducing caloric intake and/or increasing physical activity can lead to weight loss in the short to medium term in some people, they lose efficacy in the long term. Bariatric surgeries are currently the most durable and effective treatment for obesity…
Gordon M Shepherd · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $526,950 — SUMMARY/ABSTRACT Goal-directed movements of the arms and hands are essential for many activities of daily living. Dysfunction of the cortical areas controlling these behaviors is a common cause of disability. Basic neuroscience research on the underlying circuits can help to identify pathophysiologi…
Breland Crudup · UNIVERSITY OF MISSISSIPPI MED CTR · 2024 · $32,974 — Transgender individuals comprise roughly 1% of the United States population and include those born one sex but identify as a gender that does not align with their biological sex. Gender-Affirming Hormone Therapy (GAHT) is used to treat these individuals to match secondary sex characteristics to thei…
Paul Martin Coen · ADVENTHEALTH ORLANDO · 2024 · $576,804 — PROJECT SUMMARY Older adults experience a loss of mobility that leads to disability, which is a serious health care issue in an aging US population. Furthermore, the incidence of mobility disability is greater in older African Americans compared to Caucasians. The mechanisms behind these observation…
Hye Jean Yoon · VANDERBILT UNIVERSITY · 2024 · $34,285 — PROJECT SUMMARY/ABSTRACT Alcohol use disorder (AUD) is characterized by problematic alcohol consumption that evolves over an individual’s drinking history. While initial alcohol use is thought to be driven by its positive reinforcing effects, following long-term drinking, negative affective states …
Yuan Wang · FLORIDA STATE UNIVERSITY · 2024 · $398,888 — Project Summary This project will address the question of how abnormal synaptic development emerges in neurodevelopmental disorders. Our overall hypothesis is that disorganized synaptic adhesion and delayed functional assembly of synaptic vesicles (SVs) impair the formation and physiological maturat…