Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Julie A. Bastarache · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $688,098 — Project Summary This R35 application describes a robust research framework to facilitate discovery and translation of new therapeutic targets in Acute Respiratory Distress Syndrome (ARDS), a common cause of acute respiratory failure that carries a high mortality rate and has no beneficial targeted t…
TAMARA J. CASPARY · EMORY UNIVERSITY · 2024 · $221,041 — The objective of this proposal is to refine the understanding of the signaling mechanism(s) within the primary cilium in relation to polycystic kidney disease (PKD). Renal cysts interfere with kidney function and lead to major, long-term health complications. PKD and its related health complications…
Philip Andrew Moresco · STATE UNIVERSITY NEW YORK STONY BROOK · 2024 · $53,974 — Project Summary/Abstract Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer related deaths in the United States, with a five-year survival rate of 7-8%. This poor survivability can be partially attributed to late detection, however PDAC therapies have remained stagnant whic…
Michael Anthony Moody · RESEARCH TRIANGLE INSTITUTE · 2024 · $2,738,672 — PROJECT SUMMARY/ABSTRACT Emerging and re-emerging infectious disease (EID) outbreaks that are occurring with increasing frequency in high-risk areas in South/Central America, West/Central Africa, and Southeast Asia are a threat to the United States. Documented gaps in research infrastructure limit t…
John Anthony Capra · VANDERBILT UNIVERSITY · 2024 · $339,896 — PROJECT SUMMARY Our long-term goal is to establish personalized structural biology – a precision medicine approach for inter- preting clinical sequencing data by jointly modeling all mutations in a patient’s proteome in the context of protein 3D structures, known human genetic variation, and other r…
Boyi Gan · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2024 · $404,602 — Project Summary Specific genetic alterations in cancer cells may reprogram their metabolic networks and render them highly dependent on particular nutrients for survival. A mechanistic understanding of nutrient dependency in cancer cells has important implications for cancer treatment because drugs…
REBECCA G WELLS · UNIVERSITY OF PENNSYLVANIA · 2024 · $343,200 — PROJECT SUMMARY The goal of this proposal is to determine the role of fetal vs. adult wound healing programs – and the switch from one to the other that occurs around birth – in the response to fetal/early neonatal extrahepatic bile duct injury, such as occurs in biliary atresia (BA). BA is a rare d…
ROBERT H GILMAN · TULANE UNIVERSITY OF LOUISIANA · 2024 · $698,064 — Pediatric tuberculosis (TB) continues to pose diagnostic challenges in low- and middle-income countries with high rates of TB disease, due to the well-described impact of paucibacillary disease in children, and current TB culture and polymerase-chain reaction tests are of limited usefulness due to c…
Susan Nicole Hastings · DURHAM VA MEDICAL CENTER · 2024 — PROJECT SUMMARY. Persons with substantial functional disabilities--multiple limitations in activities of daily living (ADLs)--overwhelmingly prefer to remain at home. The VA faces a crisis in providing care for such Veter- ans, with increases in demand for long-term services and supports (LTSS) from…
Rebecca Tyler Brown · PHILADELPHIA VA MEDICAL CENTER · 2024 — PROJECT SUMMARY/ABSTRACT Background: Maintaining functional status, or the ability to perform daily activities such as bathing, dressing, and preparing meals, is central to older adults’ quality of life, health, and ability to remain independent. Identifying functional impairments – defined as havin…
Sharon L. Bober · DANA-FARBER CANCER INST · 2024 · $255,280 — Project Summary Sexual dysfunction is one of the most common and distressing consequences of cancer therapy for young female (YF) cancer survivors, with more than 50% of YF survivors reporting chronic sexual problems,2,3,4 including pain with sexual activity, vulvo-vaginal atrophy, and low desire. S…
Thomas F Gamage · UPSTATE MEDICAL UNIVERSITY · 2024 · $430,630 — PROJECT SUMMARY Throughout recorded history, humans have used natural products for medicinal purposes. With the onset of modern analytical and pharmaceutical methods, the active ingredients in some of these “natural remedies” were identified and became foundational chemicals in drug development effo…
Peng Jiang · RUTGERS, THE STATE UNIV OF N.J. · 2024 · $404,253 — Down syndrome (DS), caused by triplication of human chromosome 21 (HSA21), is the most common genetic origin of intellectual disability. Studying DS disease mechanism is challenging because functional human DS brain tissues are scarcely available and transgenic mouse models of DS demonstrate incompl…
Orly Lazarov · UNIVERSITY OF ILLINOIS AT CHICAGO · 2024 · $716,493 — Abstract In contrast to rodents, little is known about neurogenesis in the human brain. The few studies that examined neurogenesis in the human hippocampus have come to vastly different conclusions. Determining the existence and course of hippocampal neurogenesis in the human brain is critical for t…
Carolyn Timberlake Thorpe · VETERANS HEALTH ADMINISTRATION · 2024 — Background: Overuse of health services whose immediate or downstream costs or harms exceed their benefits (i.e., low-value health services) is a major driver of healthcare costs in the United States. Comprehensive measures of low-value service use have been applied to identify low-value services wit…
Jeffrey Frank Dunn · GORDON RESEARCH CONFERENCES · 2024 · $10,000 — PROJECT SUMMARY The field of magnetic resonance (MR) is evolving rapidly, growing in both technology development and range of applications. The rapid evolution of computer and hardware technology and the growing processing capacities and cloud based opportunities, are stimulating rapid evolution of…
JEAN F WELTER · CASE WESTERN RESERVE UNIVERSITY · 2024 · $1,119,931 — Despite significant advances over several decades, very few Tissue Engineered Medical Products (TEMPs) have been clinically or commercially successful, as a significant technology gap, known as the “Valley of Death”, has prevented their scalable, consistent and cost-effective manufacture. This propo…
JOHN BLENIS · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $681,905 — PROJECT SUMMARY The goal of this proposal is to discover how ongoing chromosome missegregation events in cancer cells (a process called chromosomal instability, or CIN) alters the tumor ecosystem to promote cancer progression. Chromosome copy number alterations (also referred to as aneuploidy) have …
Cassie Leigh McMillan · NORTHEASTERN UNIVERSITY · 2024 · $188,704 — PROJECT SUMMARY / ABSTRACT Adolescent substance use is one of the strongest predictors of drug overdose and death during adulthood. However, most individuals who initiate tobacco, alcohol, marijuana, and other drug use do not report problematic substance use at later points in the life course. To pr…
Sheng Luo · DUKE UNIVERSITY · 2024 · $458,223 — Project Summary/Abstract The proposed R01 grant is in direct response to PAR-18-352 “Methodology and Measurement in the Behavioral and Social Sciences (R01)”. Alzheimer's disease (AD) is a progressive, neurodegenerative disorder that causes impairment in multiple domains (e.g., cognition, behavior, …