Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Sadiya Sana Khan · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $707,865 — ABSTRACT Chronic lung disease and heart failure (HF) are highly prevalent, commonly co-occur, and are associated with significant morbidity and mortality. Work from our group and others has demonstrated an independent relationship between chronic lung disease and incident HF that may be driven in p…
Lameck Chinula · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $268,261 — PROJECT SUMMARY Globally, there are more deaths from cancer than from HIV, tuberculosis, and malaria combined. In 2018, there were more than 18 million new cancer cases and 9.5 million cancer deaths worldwide, and, by 2030, these numbers will increase by at least 50%. Countries with low or medium Hu…
Chris Gregory · RALPH H JOHNSON VA MEDICAL CENTER · 2024 — More than 2 million stroke survivors currently living in the U.S. are obese. Obesity is known to exacerbate age- related declines in function in these individuals and is associated with poorer clinical outcomes and quality of life. Weight-loss interventions are well-studied in neurologically healthy…
John S Chorba · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $363,375 — PROJECT SUMMARY/ABSTRACT Serum low-density lipoprotein (LDL) causes atherosclerotic heart disease. As the LDL receptor (LDLR) on the liver clears LDL from the blood, upregulating hepatic LDLR reduces both LDL and cardiovascular events. The self-cleaving protease PCSK9 (proprotein convertase subtilis…
PETER D. ADAMS · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · 2024 · $514,488 — PROJECT SUMMARY Chromatin is a key determinant of cell phenotype and function. Therefore, chromatin stability over the lifespan is presumably a pre-requisite for maintenance of cell and tissue phenotype and function, and hence healthy aging and longevity. However, chromatin is not a static fixed str…
Nanette F. Santoro · UNIVERSITY OF COLORADO DENVER · 2024 · $340,200 — PROJECT SUMMARY The Colorado Womens Reproductive Health Research Career Development Program (`Colorado WRHR') hereby seeks its 4th funding cycle. We have succeeding in creating independent investigators in Obstetrics and Gynecology and plan to continue to do so by: adapting our strategic research pl…
JIANGUO GU · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2024 · $489,359 — ABSTRACT: The sense of touch is critical for daily tasks including tactile discrimination, social interaction, and environmental exploration. The overall objective of this project is to identify the cellular and molecular mechanisms underlying the sense of touch in mammals. Previous studies have sh…
JOHN Christopher KAPPES · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2024 · $185,625 — PROJECT SUMMARY/ABSTRACT There are approximately 1.3 million transgender adults in the US, and about 467,000 of these individuals (~36%) are transgender men. Transgender men are individuals who were assigned female at birth but identify as male. Trans men may transition physiologically from female t…
Constantinos Anastassiou · CEDARS-SINAI MEDICAL CENTER · 2024 · $547,234 — Project Summary The past decade has seen an unprecedented accumulation of data at the single-cell level giving rise to unique, multimodal sets of gene expression patterns, morphologies, and electrophysiology characteristics. This high- resolution census of neuronal types in the brain constitutes an …
Benjamin L Wolozin · BOSTON UNIVERSITY MEDICAL CAMPUS · 2024 · $610,029 — SUMMARY New variants, especially in non-coding regions, are expected to be discovered through the ongoing AD Sequencing Project (ADSP). This proposal will investigate circular RNAs (circRNAs) and RNA binding proteins (RBPs) that regulate or are regulated by these circRNAs. Recent genomic studies hav…
Dean Mobbs · CALIFORNIA INSTITUTE OF TECHNOLOGY · 2024 · $673,808 — Project Abstract The fundamental objective of this proposal is to fractionate human defensive circuits and behaviors. Our approach addresses three key issues. These include the knowledge that: (i) experimental paradigms have failed to fractionate the diverse subjective emotions and neural representa…
Scott A Berceli · UNIVERSITY OF FLORIDA · 2024 · $360,176 — PROJECT SUMMARY/ABSTRACT The design and implementation of improved therapies for vascular diseases are dependent on a better understanding of the basic physiological processes involved. Such processes are biologically complex, with elements at the molecular, cellular, organ system, and integrative …
IRFAN RAHMAN · FLORIDA INTERNATIONAL UNIVERSITY · 2024 · $517,266 — Title: Resetting the Clock on HIV associated COPD PROJECT SUMMARY The long-term goal of this proposal is identifying the role of aberrant circadian-coupled gene expression linking HIV and lung inflammation as a fundamental starting point to understand the pathophysiological mechanism in HIV associa…
Charissa Camille Naidoo · STELLENBOSCH UNIVERSITY · 2024 · $89,609 — PROJECT SUMMARY The human microbiome is an essential mediator of health and influences important metabolic functions through production of short chain fatty acids (SCFAs). These compounds have been shown to independently predict risk for developing tuberculosis (TB) – a leading cause of death in Sou…
Aaron William Murnan · UNIVERSITY OF CINCINNATI · 2024 · $192,107 — Project Summary/Abstract Aaron Murnan, PhD, LMFT is a tenure-track assistant professor at University of Cincinnati's College of Nursing. His career goal is to become an independent clinician-scientist with expertise in co-designing novel interventions to address salient treatment needs among familie…
JAE H KANG · MASSACHUSETTS EYE AND EAR INFIRMARY · 2024 · $496,614 — Exfoliation syndrome (XFS) is a common systemic disorder characterized by progressive accumulation of abnormal fibrillar protein aggregates and that is associated with glaucoma (XFG), pre-mature cataract formation, and complications during cataract surgery as well as several systemic conditions. Our…
Christine Anne Pratilas · JOHNS HOPKINS UNIVERSITY · 2024 · $541,365 — PROJECT SUMMARY/ ABSTRACT There has been little advancement in overall survival for patients with malignant peripheral nerve sheath tumor (MPNST), despite decades of research and many clinical trials, and thus novel therapies are needed. While loss of NF1 GTPase-activating protein function suggests …
Wenjian Gan · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2024 · $377,500 — Abstract Arginine methylation is one of the most common posttranslational modifications (PTMs), which is comparable to phosphorylation and ubiquitination. Protein arginine methyltransferases (PRMTs) correspond to “writers” that generate three types of methylated arginine residues: monomethylarginine…
John Barnard · CLEVELAND CLINIC LERNER COM-CWRU · 2024 · $716,119 — PROJECT SUMMARY Although ablation to isolate pulmonary vein (PV) triggers has revolutionized atrial fibrillation (AF) management, performing effective AF ablation remains challenging. The procedure remains limited by targeting of ill-defined substrates, a 2-6% risk of major complications and limited…
Michael Simons · YALE UNIVERSITY · 2024 · $645,489 — Project Summary Uncontrolled inflammation is a key driver of acute and chronic cardiovascular pathology. However, the accompanying edema, one of the four cardinal signs of inflammation defined by Celsus and Galen two millennia ago, is poorly understood and often ignored at the mechanistic level. Yet…