Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Allan L Reiss · STANFORD UNIVERSITY · 2024 · $343,091 — This application represents a competitive renewal of a highly-successful institutional postdoctoral training grant based in Stanford's Center for Interdisciplinary Brain Sciences Research (CIBSR), under the direction of Dr. Allan Reiss. The training program is situated within an exceptionally divers…
Christal Dyane Sohl · SAN DIEGO STATE UNIVERSITY · 2024 · $376,250 — ABSTRACT/SUMMARY The consequences of mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 in cancer are unusual. Though these mutations confer a loss of function of the normal activity of the NADP+-dependent conversion of isocitrate to α-ketoglutarate (αKG), mutant IDH is more of an oncogene than…
Katarzyna Zwolinska · LOUISIANA STATE UNIV HSC SHREVEPORT · 2024 · $367,373 — Little is known about the immediate early events of the human papillomavirus (HPV) lifecycle. This is mostly due to the lack of a cell culture model allowing efficient infection of primary keratinocytes and at the same time a genetic analysis of viral factors. We have recently described such a syste…
Akira Ono · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $682,812 — Virus particle assembly of HIV-1, the causative agent of AIDS, takes place at the plasma membrane (PM) in most cell types including natural host T cells. This process is driven by a viral structural protein Gag. The N-terminal matrix (MA) domain of Gag determines Gag localization to and hence virus …
Heather Greenlee · FRED HUTCHINSON CANCER CENTER · 2024 · $696,497 — PROJECT SUMMARY / ABSTRACT Breast cancer (BC) is the leading cause of cancer death among US Latinas. Latinas are at high risk of obesity and obesity-related diseases, which are associated with poorer cancer outcomes. There is a significant lack of an effective intervention to address the diverse nee…
Emmanuel Zorn · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $205,625 — Project Summary Serum IgM have crucial “housekeeping” functions such as the clearance of apoptotic cells and cellular debris, preventing their accumulation in tissue. However, despite their important role, IgM have been largely understudied in comparison to other immunoglobulin isotypes, especially …
Michinari Nakamura · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · 2024 · $392,500 — PROJECT SUMMARY Pathological hypertrophy can progress to failing heart. During the transition, fatty acid utilization is decreased, while utilization of other substrates, such as ketone body, is increased. Multiple lines of evidence indicate that increased myocardial ketone body utilization is an ad…
Florencia McAllister · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2024 · $352,047 — Abstract The incidence of pancreatic adenocarcinoma (PDAC) is steadily increasing while most treatment modalities remain ineffective. Therefore, it would not be a surprise to learn that PDAC is one of the top-4 causes of cancer- related mortality. What is most striking about this malignancy is that …
Michael L Wallace · BOSTON UNIVERSITY MEDICAL CAMPUS · 2024 · $561,579 — Project Summary Serotonin (5-HT)-releasing neurons in the mammalian mid/hindbrain are critical for fundamental behaviors and cognitive processes, including emotional control, arousal, and motor control. Selective serotonin reuptake inhibitors (SSRIs) increase brain 5-HT levels and are the most commo…
Boone M. Prentice · UNIVERSITY OF FLORIDA · 2024 · $152,324 — PROJECT SUMMARY Molecular imaging plays a pivotal role in biomedical research. By enabling the visualization of biological processes directly in tissue, in situ assessments of cellular function can be recorded with spatial context. The use of mass spectrometry as a molecular imaging modality combine…
Jonathan M Kurie · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2024 · $530,294 — Cancer cells are embedded in a protective and nourishing “niche”, an environment that cancer cells create by secreting proteins into their surroundings. Because cancer cells depend on their niche to survive and spread to other parts of the body, we believe that therapies designed to inhibit secretio…
ALEXANDER A SOUKAS · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $420,000 — A growing body of evidence suggests that metformin effects on mitochondria are responsible for its ability to lower blood glucose and reduce the growth and incidence of cancer. In model systems, metformin prolongs lifespan, and observational studies in humans similarly suggest a longevity benefit fo…
John Paul Condon · INNOVATIVE DESIGN LABS, INC. · 2024 · $895,438 — Project Summary/Abstract The proposed project focuses on creating a simulation system that provides hands-on skills training of musculoskeletal, soft tissue, and ligament function for medical and health science students. Significance: Musculoskeletal (MSK) disorders are the most frequent chronic hea…
Fuzheng Guo · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $494,091 — The curious case of PARP1 in CNS myelin formation and repair Current anti-inflammatory drugs diminish immune attacks yet are ineffective in preventing neurological progression of multiple sclerosis (MS), the most common demyelinating disorder of the central nervous system (CNS) with no cure affecti…
Khosrow Samuel Rezvani · UNIVERSITY OF SOUTH DAKOTA · 2024 · $74,750 — Project Summary Colorectal cancer (CRC) has a high mortality rate due to metastasis and drug resistance. CRC cells develop metastatic characteristics by hijacking different signaling pathways to fuel tumor heterogeneity and facilitate cancer migration and invasion. Additionally, the metabolic adapta…
Ivan Zanoni · BOSTON CHILDREN'S HOSPITAL · 2024 · $646,238 — Inflammation evolved to lead to recovery from sterile or microbial injuries. The induction of the inflammatory process not only activates the immune cells, but also alters their metabolism and thus forge the immune response. Accumulating evidence shows that a proper inflammatory process requires the…
Kim M. Gans · BROWN UNIVERSITY · 2024 · $306,687 — The preschool years are a critical time for shaping food preferences and eating behaviors which, in turn, affect dietary behaviors in adults and life-long risks for obesity, diabetes, cardiovascular disease and other chronic conditions. Unfortunately, many US children, especially low-income and ethn…
YUYING LIANG · UNIVERSITY OF MINNESOTA · 2024 · $227,848 — Abstract Title: Novel multivalent viral vectored tuberculosis vaccines targeting lung immunity Tuberculosis (TB) persists as the deadliest bacterial infection, with more than 10 million new cases of active TB diagnosed and 1.5 million deaths attributed to TB worldwide each year, because there is no …
Joshua T Thaden · DUKE UNIVERSITY · 2024 · $177,981 — ABSTRACT Clinical outcomes in invasive gram-negative bacterial infections are determined by the interplay of patient, treatment, and bacterial variables. Significant progress has been made in understanding patient and treatment factors; however, little is known about how bacterial genetic variation …
Scott M. Dehm · UNIVERSITY OF WISCONSIN-MADISON · 2024 · $625,914 — PROJECT SUMMARY/ABSTRACT The last decade has seen a significant increase in the number of FDA approved treatments for men with metastatic castrate resistant prostate cancer (mCRPC). Even greater improvements in survival were observed for men with metastatic castration sensitive PC (mCSPC) treated wi…