Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Julia Johnson · JOHNS HOPKINS UNIVERSITY · 2024 · $171,720 — Project Summary/Abstract Annually, 2.5 million babies die within the first four weeks of life, nearly a quarter due to infectious causes. Newborns admitted to the Neonatal Intensive Care Unit (NICU) are especially vulnerable, due to such factors as prematurity, an immature immune system, and need fo…
Diany Paola Calderon · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $487,477 — Project Summary Monitoring the transition to wakefulness is critical during restoration to consciousness after brain injury, anesthesia, and in those COVID-19 survivors that have altered consciousness. However, we have an imprecise understanding of neural dynamics linked to behavioral changes as sub…
Mustafa R. Bashir · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $799,358 — Project Summary Hepatocellular carcinoma (HCC) is the fastest growing cause of cancer death in the United States. Recent North American practice guidelines recommend semi-annual HCC surveillance using ultrasound (US) with or without serum alpha-fetoprotein (AFP) for cirrhotic and other high-risk pat…
Yolanda Vasquez-Salgado · CALIFORNIA STATE UNIVERSITY NORTHRIDGE · 2024 · $181,250 — 2.0 PROJECT SUMMARY/ABSTRACT Stress may play a significant role in the finding that Latinx students enroll in college but are less likely to graduate than students from other racial/ethnic groups. Prior qualitative, survey, and experimental work suggests that Latinx first-generation college (FGC) s…
Brian Bruce Monson · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · 2024 · $411,223 — The World Health Organization reports that nearly a half billion people suffer from a disabling hearing loss worldwide. Hearing loss is typically measured in the standard audiometric frequency range, 250 to 8,000 Hz. However, the young, healthy human frequency range of hearing extends to about 20,00…
Donald B DeFranco · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $579,211 — Bronchopulmonary dysplasia (BPD) remains a significant complication of prematurity affecting nearly 70% in infants born ≤28 weeks. Current pharmacologic strategies to mitigate the development and progression of BPD include administration of long-acting synthetic glucocorticoids (sGCs) such as dexame…
Thu Nguyen · UNIV OF MARYLAND, COLLEGE PARK · 2024 · $586,570 — PROJECT SUMMARY/ABSTRACT This proposal has the potential to alter the way health information is presented to vulnerable populations. Our proposal promotes a more flexible and tailored approach to reach underserved groups. Racial/ethnic minority women are at increased risk for postpartum depression, …
Michael T Kinter · UNIV OF ARKANSAS FOR MED SCIS · 2024 · $1,927,802 — ABSTRACT Through PAR-19-301, NIGMS seeks to support mission relevant resources that will have the economy of scale to provide increased access to state-of-the-art services for a substantial regional or national user base. In response, we are applying for NIGMS National Resource support for the IDeA…
Natalie Lea Silver · CLEVELAND CLINIC LERNER COM-CWRU · 2024 · $155,304 — PROJECT SUMMARY/ABSTRACT Oral cavity squamous cell carcinoma (OCSCC) is a very aggressive and deadly disease with poor survival rates following maximal treatments such as surgery and chemoradiotherapy. The immunosuppressive tumor microenvironment (TME) is a major barrier of response to traditional …
ANDREW L ALEXANDER · UNIVERSITY OF WISCONSIN-MADISON · 2024 · $2,283,568 — PROJECT SUMMARY/ABSTRACT Autism spectrum disorder (ASD) is a lifelong disorder that has consequences throughout adulthood. Recent population health studies indicate that aging autistic adults have shorter life expectancy and increased rates of physical and mental health problems. However, there is a…
Stacie Luther Daugherty · KAISER FOUNDATION RESEARCH INSTITUTE · 2024 · $774,872 — PROJECT SUMMARY/ABSTRACT Societal systems of racism, segregation, and criminal justice practices have resulted in high rates of imprisonment of Black, Indigenous, and other People of Color (BIPOC) and represent structural racism and discrimination (SRD). Upon release from prison, people face further…
Jeremy Elliot Orr · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $169,893 — Project Summary/Abstract This proposal details a five-year research and career development plan for Jeremy E. Orr, M.D., a specialist in pulmonology and critical care medicine, and Assistant Professor of Medicine at the University of California, San Diego. His research has been supported by a Nation…
Rachel S Friedman · NATIONAL JEWISH HEALTH · 2024 · $243,594 — PROJECT SUMMARY T cells specific for pancreatic beta cell antigens drive an autoimmune response leading to type 1 diabetes (T1D). During the onset of T1D, many immune cell types infiltrate into pancreatic islets, but the infiltration of each individual islet varies substantially within an individua…
Andrew P. Landstrom · DUKE UNIVERSITY · 2024 · $670,378 — PROJECT SUMMARY/ABSTRACT Sudden unexplained death in epilepsy (SUDEP) is the sudden and unexplained death of a patient with a history of seizures and epilepsy who is in a reasonable state of health. It is a major cause of death in patients with epilepsy and a common cause of neurologic death overall…
Colin K Combs · WEST VIRGINIA UNIVERSITY · 2024 · $598,003 — ABSTRACT: There are significant differences between men and women in the incidence and severity of late- onset Alzheimer’s Disease (LOAD). After menopause, women are more likely to develop LOAD, and symptoms of the disease including cognitive impairment are more severe. These symptoms are exacerbate…
CLARE L BARRINGTON · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $78,491 — Project Summary/Abstract: Transgender (trans) women across the globe experience a disproportionate burden of HIV with an estimated global HIV prevalence of 19%. Trans women living with HIV also have worse HIV care and treatment outcomes than cisgender adults, including lower rates of viral suppressi…
MELISSA L. BONDY · STANFORD UNIVERSITY · 2024 · $1,879,074 — Overall Component: Project Summary/Abstract Persistent poverty environments impose particular challenges for cancer prevention, with complex and intersecting factors creating barriers at the individual, health system, and population level. Improving cancer outcomes in these areas requires transforma…
Julia V Busik · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2024 · $379,250 — Abstract Bone marrow (BM)-derived vascular reparative cells, called myeloid angiogenic cells or MACs, are critical in vascular repair due to their ability to release growth factors and immunomodulatory proteins that promote endothelial survival and proliferation. MAC dysfunction in diabetes may lead…
Andrew Olive · MICHIGAN STATE UNIVERSITY · 2024 · $523,984 — Summary Tuberculosis (TB) is a leading cause of death by infectious disease worldwide. Current therapy requires at least six months of treatment and there is no effective vaccine that prevents pulmonary disease. There is a critical need to develop new therapies that will shorten treatment time and a…
Roderick O'Sullivan · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $349,752 — ABSTRACT Cancer cells must activate a telomere elongation mechanism and acquire genomic alterations to survive. Many of the most lethal cancers rely on the Alternative Lengthening of Telomeres (ALT) telomere elongation pathway. ALT is strongly associated with recurrent mutations in genes encoding ch…