Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Anne George · UNIVERSITY OF ILLINOIS AT CHICAGO · 2024 · $487,987 — For dentin repair or regeneration, it is important to have the timely appearance of blood vessels. Therefore, tissue-engineering strategies to regenerate the dentin-pulp complex require establishment of vasculature to deliver oxygen, nutrients, hormones, immune cells, minerals and also help in clear…
Amanda Louise Neisch · UNIVERSITY OF MINNESOTA · 2024 · $193,750 — Project Summary Alzheimer’s disease is polygenic, yet the molecular functions and contributions to disease progression of many genetic factors are not understood. Mob4 is a gene whose expression is significantly downregulated in Alzheimer’s disease and whose function is yet to be determined. The goa…
Tao Zou · DANA-FARBER CANCER INST · 2024 · $208,829 — PROJECT SUMMARY/ABSTRACT Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related mortality worldwide. The development of targeted molecular therapies that inhibit mutant oncogenic proteins and immunotherapies that inhibit the PD- 1/PD-L1 pathway have improved outcomes for subsets of …
Manu Banadakoppa · BAYLOR COLLEGE OF MEDICINE · 2024 · $401,250 — Preeclampsia (PE) is a pregnancy-specific syndrome and several putative mechanisms have been implicated in the pathogenesis of PE including complement (C) cascade activation. C activation byproducts in the circulation are elevated with pregnancy in women and they are further elevated significantly i…
Marlies Meisel · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $422,344 — Autoimmune hepatitis (AIH) is a chronic, progressive, auto-inflammatory liver disorder that often becomes refractory to immunosuppressants-the sole therapeutic option for AIH patients. Hepatic inflammation, which sets the stage for overt AIH, is considered the main driver of hepatic tissue damage an…
ROBIN Lynn HAYNES · BOSTON CHILDREN'S HOSPITAL · 2024 · $715,459 — Project Summary Sudden infant death syndrome (SIDS) remains the leading cause of post-neonatal mortality in the U.S.– an unchanging and devastating fact despite implementation of safe sleep practices (extrinsic risk reduction). Addressing this 21st century health crisis now requires discovery of int…
Shadmehr Demehri · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $660,987 — Project Summary/Abstract: Natural killer (NK) cells have long been known to provide critical early defense against viral infections and malignancies. Nevertheless, most of the clinical success associated with using NK cells has been restricted to hematological malignancies, which can be partly attri…
Charles R Farber · UNIVERSITY OF VIRGINIA · 2024 · $773,856 — Project Summary: Reduced bone strength is a hallmark of many bone disorders, including osteoporosis, a debilitating disease affecting millions of Americans. The strength of bone is influenced by multiple characteristics of bone including microarchitecture, biomechanical properties (e.g., stiffness),…
KJ Suda · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $92,419 — ABSTRACT: The overarching goal of this candidate’s research is to address the health care needs of underrepresented children diagnosed with a resonance disorder of hypernasality to establish potential programs and interventions to increase access to needed health care services. The focus is hypernas…
Vijay Ramakrishnan · INDIANA UNIVERSITY INDIANAPOLIS · 2024 · $752,420 — SUMMARY: Chronic rhinosinusitis (CRS) is a highly prevalent disease that inflicts a severe quality-of-life (QOL) impairment, with local symptoms of nasal blockage, congestion, loss of smell, nasal drainage, headache, and recurrent infections. CRS is also appreciated for its prominent role as a compo…
Jian-Xing Jay Ma · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2024 · $474,114 — Diabetes-induced retinal inflammation plays an important pathogenic role in diabetic retinopathy (DR). Microglial activation is a key step in retinal inflammation in DR. The molecular mechanism for the microglial activation in DR remains elusive. Peroxisome Proliferator-Activated Receptor α (PPARα) …
Philip J Horner · METHODIST HOSPITAL RESEARCH INSTITUTE · 2024 · $204,214 — Neural activity directly controls the development and homeostasis of organ function. Yet, a surprising gap exists between laboratories focused on vascular, gastrointestinal, immune, and musculoskeletal systems and those focused on neurophysiology, neuromodulation, and neural injury. Traditionally, d…
Manhattan E Charurat · UNIVERSITY OF MARYLAND BALTIMORE · 2024 · $1,036,244 — PROJECT ABSTRACT This application presents the Integrated Networks of Scholars in Global Health Research Training (INSIGHT) Program. We have 145 faculty members across our multidisciplinary and multi-institutional consortium working together with 24 low- and middle-income countries (LMIC) institutio…
Michaela R. Reagan · MAINEHEALTH · 2024 · $373,778 — Cancer develops and spreads because of the nature of the tumor and the microenvironment or `soil' in which the tumor is embedded. Multiple myeloma is a blood cancer that results from mutations that accumulate in a plasma cell. Multiple myeloma cells grow in the rich soil of the bone marrow, first ve…
Wasif A Osmani · MEDICAL COLLEGE OF WISCONSIN · 2024 · $51,064 — Abstract: Epilepsy is one of the most common neurological conditions in the world. Treatment with anti-epileptic drugs (AEDs) prevent recurrent seizures in ~70% of patients with epilepsy, but the remaining 30% of patients with refractory epilepsies continue to experience uncontrolled seizures. The n…
Saranna Fanning · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $692,401 — Establishing mechanism-based therapeutics for Parkinson’s disease (PD), Lewy body dementia (LBD) and other synucleinopathies is a biomedical priority. Neuropathological and genetic discoveries implicate α-synuclein (αS) in familial and ‘sporadic’ PD. Recent publications identify significant lipid co…
Amy Caroline Justice · VA CONNECTICUT HEALTHCARE SYSTEM · 2024 — Detecting Genetic Susceptibility for Fatty Liver Disease in Lean vs. Non-lean Individuals: Use of a Deep Learning Algorithm PROJECT SUMMARY/ABSTRACT Fatty liver disease (FLD) is the most common liver disease in the world, affecting nearly 1 billion people. Although it commonly occurs among overweigh…
Qingfei Jiang · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $476,234 — SUMMARY/ABSTRACT Relapsed pediatric T-cell acute lymphoblastic leukemia (T-ALL) is often refractory to conventional therapy and is associated with a dismal survival rate of less than 25%. Thus, the development of novel therapies for relapsed T-ALL represents an urgent unmet medical need in children.…
Christina Furber Mair · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $473,374 — PROJECT ABSTRACT Despite increased attention over the past decade, alcohol-involved sexual violence continues to be widespread on college campuses. Existing interventions, which include bystander training, education programs, and brief interventions, take an essentially global approach to the preven…
JEFFREY R. BENDER · YALE UNIVERSITY · 2024 · $296,794 — This is the fourth competing renewal application for Yale University’s Vascular Research Postdoctoral T32. Of fellows who have completed training to date, 65% have obtained academic faculty positions and/or careers in science, and many have received independent grant support, strong indicators of pr…