Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Kathryn Kixmoeller · UNIVERSITY OF PENNSYLVANIA · 2024 · $7,079 — Project Summary Accurate segregation of chromosomes during cell division is one of the most fundamental requirements in biology. Without proper chromosomal segregation, genetic information cannot be faithfully transmitted across cell and organismal generations, leading to severe consequences includi…
JAN NOVAK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2024 · $643,133 — Abstract IgA nephropathy (IgAN) is the most common primary glomerulonephritis in the world. Unfortunately, many patients progress to kidney failure. IgAN is defined by the characteristic IgA1 mesangial deposits. Based on our published data, we proposed a hypothesis that describes sequential steps in…
Jiyeon Kim · YALE UNIVERSITY · 2024 · $480,137 — PROJECT SUMMARY Given the important roles of tumor suppressors and oncogenes in metabolic reprogramming, there is significant translational potential in identifying and understanding how particular oncogenotypes influence tumor metabolism, and whether these changes impose liabilities that can be ex…
Andy Y Shih · SEATTLE CHILDREN'S HOSPITAL · 2024 · $683,367 — The constriction and regression of brain capillaries is well documented in Alzheimer’s disease and Vascular Contributions to Cognitive Impairment and Dementia (AD/VCID). There is strong preclinical and clinical evidence to suggest that contraction of pericytes leads to abnormal capillary constrictio…
Douglas Glenn Brownfield · MAYO CLINIC ROCHESTER · 2024 · $638,986 — PROJECT SUMMARY The alveolus is lined by two epithelial cell types: thin gas-exchanging alveolar type 1 (AT1) cells and cuboidal surfactant-producing AT2 cells. Both are selected from a common distal progenitor by FGF, Notch, and stretch signaling. Injury in the adult lung activates AT2 into a facul…
Antonis Kourtidis · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2024 · $465,803 — PROJECT SUMMARY Colorectal abnormalities such as pre-cancerous fibrotic disease and colon cancer are prevalent. However, the mechanisms that link the extensive extracellular matrix (ECM) remodeling that occurs during fibrosis to pro- tumorigenic cell transformation are still poorly understood. Compr…
RICHARD W FITCH · INDIANA STATE UNIVERSITY · 2024 · $250,000 — Project Summary/Abstract. Indiana State University serves a broad student base from diverse backgrounds. A large fraction (38%) of our students are Pell Grant eligible (47% of first-year, full-time freshmen). Our students are a mix of students from urban and rural environments including a large frac…
PATRICK J O'CONNOR · HEALTHPARTNERS INSTITUTE · 2024 · $657,621 — PROJECT SUMMARY Among the estimated one million Americans who have screened positive for specific genetic variants related to Hereditary Breast and Ovarian Cancer Syndrome (HBOC) or Lynch Syndrome (LS), less than half are up to date on evidence-based cancer prevention measures that may increase earl…
Kathleen M Hill Gallant · UNIVERSITY OF MINNESOTA · 2024 · $665,821 — PROJECT SUMMARY/ABSTRACT Chronic kidney disease (CKD) is highly prevalent, affecting approximately 37 million U.S. adults. CKD- mineral and bone disorder (CKD-MBD) is a common comorbidity of CKD that results in increased risk of cardiovascular and bone disease and associated morbidity and mortality…
Mia E Hofstad · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $39,711 — ABSTRACT Prostate cancer is the most common non-skin malignancy in men and is projected to cause 34,500 deaths in 2022 in the United States alone. Sequencing studies of advanced lethal castrate resistant prostate cancer (CRPC) have identified a high incidence (~13%) of pathogenic BRCA2 mutations. Th…
ALEXANDER J VARSHAVSKY · CALIFORNIA INSTITUTE OF TECHNOLOGY · 2024 · $575,028 — Project Summary/Abstract Regulated proteolysis by the ubiquitin-proteasome system (ubiquitin system) plays essential roles in a multitude of biological processes and has major ramifications for human health and disease, including illnesses that range from cancer and neurodegeneration to cardiovascu…
Suzie Chen · VA NEW JERSEY HEALTH CARE SYSTEM · 2024 — Much has been learned about the molecular pathology of melanoma in recent years and significant progress has been made towards its treatment, yet late-stage melanoma still remains one of the least curable cancers with high metastatic propensity. The brain is a common site of metastasis for patients …
Amanda Cristina Venta · UNIVERSITY OF HOUSTON · 2024 · $341,120 — Modified Project Summary/Abstract Section Posttraumatic distress disproportionately affects Hispanic immigrants due to high rates of trauma exposure in their home countries and continued trauma. The proposed study will collect longitudinal data from 400 Hispanic immigrant adults to examine how traum…
Jason G Cyster · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $562,480 — Project Summary/Abstract The intestinal immune system plays crucial roles in maintaining tissue and microbiome homeostasis and in protecting from pathogens. Two major classes of intestinal immune cells are the intraepithelial lymphocytes (IEL) and IgA producing cells. The factors controlling the co…
Jun-Yong Choi · QUEENS COLLEGE · 2024 · $249,986 — Project Summary The requested instrument is a CEM microwave-assisted peptide synthesizer, the Liberty Prime 2.0 HT12 System, which builds up chemical libraries of peptidomimetics and produces small-size enzymes possessing >100 amino acids. With the aid of microwave heating system, the synthesizer f…
Safiya Richardson · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $785,951 — PROJECT ABSTRACT Every year 2.4 million CT scans are performed to evaluate for pulmonary embolism (PE) in Emergency Departments (ED) in the United States. Approximately one-third of studies are avoidable, with each scan resulting in unnecessary exposure to radiation and increasing risk for iatrogeni…
Bisrat G Debeb · UNIVERSITY OF TEXAS AT AUSTIN · 2024 · $669,122 — Highly aggressive cancers are frequently characterized by tumor cell emboli within the lymphatic and blood vasculature. Termed lymphovascular space invasion (LVSI), this phenomenon has been of high interest to cancer researchers as it may represent one of the necessary events during progression from…
Helen N Schwerdt · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $557,736 — Project Summary Real-life learning occurs through feedback in the form of reward or punishment. Dopamine is a key molecule in the brain known to play a central role in learning from rewards. However, the role of these molecules in learning from punishments, or a combination of positive and negative …
Denise J. Montell · UNIVERSITY OF CALIFORNIA SANTA BARBARA · 2024 · $371,183 — During normal embryonic development, wound healing and cancer metastasis, cells move collectively, making and breaking cell-cell contacts as they squeeze between other cells and tissues. Individual cells can leave an epithelium by undergoing the epithelial to mesenchymal transition. However, the pro…
JINGFANG JU · NORTHPORT VA MEDICAL CENTER · 2024 — Project Summary/Abstract The goal of this application is to investigate the roles of miR-15a in colorectal cancer and to develop novel miR-15a mimic as potential therapeutics to treat advanced metastatic colorectal cancer in both male and female Veterans. Despite advancements in early detection and …