Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Margaret Lise Gardel · UNIVERSITY OF CHICAGO · 2024 · $393,173 — Project Summary Mechanisms of Mechanotransduction by LIM Domain Proteins Mechanical forces are essential to controlling the shape, movement and even many aspects of cell physiology. Changes in the environment mechanics or defects in cellular mechanoresponse are implicated in a plethora of diseases i…
Jose Francisco Huizar · VA VETERANS ADMINISTRATION HOSPITAL · 2024 — Cardiovascular disease is the leading cause of death in developed countries. A common treatment for atherosclerotic cardiovascular disease is placement of an arterial stent. While stent technology has improved over the years, including the development of drug-eluting stents, failure rates remain hig…
Alexandria Gabrielle Bauer · RUTGERS, THE STATE UNIV OF N.J. · 2024 · $197,181 — Project Summary/Abstract Black/African American young adults are at elevated risk for trauma and related mental health concerns (e.g., PTSD, substance use) yet are less likely to engage in mental health care than other groups, due to substantial and complex barriers to care. These disparities have b…
Deborah Johnson-Shelton · SAAVSUS, INC. · 2024 · $960,153 — ABSTRACT Child abuse, peer violence, and injury continue to be major public health challenges, jeopardizing the healthy development of millions of American children every day. Post-pandemic, elementary schools are reporting significant delays in children’s social development, as well as higher rates…
Gundeep Singh Dhillon · STANFORD UNIVERSITY · 2024 · $412,076 — PROJECT SUMMARY / ABSTRACT Lung transplantation (LT) recipients suffer from life-threatening pulmonary infections that can trigger acute rejection and death. Although vaccination is the most effective way for preventing infections, vaccine efficacy is limited in immunocompromised solid organ transpl…
Krista Milich · WASHINGTON UNIVERSITY · 2024 · $667,311 — Many infectious diseases that threaten humans originated among wildlife, yet we know relatively little about the real-world ecological conditions that enable spillover events. Despite its importance, identifying novel viral pathogens and characterizing their transmission dynamics remains difficult…
Karen Sue Anderson · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · 2024 · $963,127 — Project Summary/Abstract The goal of the EDRN Southwest Clinical Validation Center for Head and Neck Cancer is to improve oropharyngeal cancer screening through the rigorous validation of salivary biomarkers. The scientific approach of our Center is based on several fundamental principles. First, th…
GREGORY F. COOPER · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $575,480 — Abstract More than 790,000 patients undergo mechanical ventilation for acute respiratory failure (ARF) in the United States each year at a cost of $27 billion. The in-hospital mortality for these patients is nearly 35%, and for patients with critical illness, such as acute respiratory distress syndr…
CHRISTOPHER G CHUTE · JOHNS HOPKINS UNIVERSITY · 2024 · $502,164 — PROJECT SUMMARY Johns Hopkins University has recently re-established a multi-disciplinary, multi-school education program in Biomedical Informatics and Data Science (BIDS). The program is centrally coordinated and managed by the newly established Section of Biomedical Informatics and Data Science…
Christopher Alan Haiman · UNIVERSITY OF SOUTHERN CALIFORNIA · 2024 · $1,620,203 — African American (AA) men have a >80% higher incidence and are more than twice as likely to die from prostate cancer (PCa) than white men. The reasons for the high burden relating to poor outcomes of PCa among AA men are largely unknown. RESPOND is a nation-wide and comprehensive effort to understan…
Adam Korrick Lewkowitz · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · 2024 · $179,621 — The prevalence of depression is high after childbirth: rates of postpartum depression (PPD) are as high as 25% among women without prior PPD or depression but with personal or structural risk factors such as being low- income or a women of color, among others. As such, the American College of Obstet…
Huiman X Barnhart · DUKE UNIVERSITY · 2024 · $949,598 — PROJECT ABSTRACT Recognizing the significant impact of structural racism on kidney health in minority populations, the NIH is creating a new Consortium focused on Interventions that Address Structural Racism to Reduce Kidney Health Disparities. The Consortium will bring together research teams from …
ANNE LYNCH · BAYLOR COLLEGE OF MEDICINE · 2024 · $48,974 — PROJECT SUMMARY/ABSTRACT Lower respiratory infections were the fourth leading cause of death worldwide for nearly twenty years, and in 2019 with the onset of the COVID-19 pandemic, respiratory infections quickly rose to the leading cause of death in many countries killing over 5 million people world…
Charles A. Easley · MOREHOUSE SCHOOL OF MEDICINE · 2024 · $203,338 — Project Summary This new application seeks NIEHS RISE (R25) sponsorship for our innovative advanced program entitled “Frontiers in Environmental Science and Human Health (FrESH)” to train and mentor promising graduates, medical students, post-doctoral fellows and junior faculty from predominantly un…
George L Anesi · UNIVERSITY OF PENNSYLVANIA · 2024 · $718,366 — PROJECT SUMMARY Decisions to admit patients with acute respiratory failure (ARF) and sepsis (the most common and lethal cause of the acute respiratory distress syndrome) to intensive care units (ICUs) are highly variable across the US. And, yet, these triage decisions have a substantial impact on pa…
Nia Schwann Mitchell · DUKE UNIVERSITY · 2024 · $112,673 — Abstract of the Funded Parent Award Older African American (AA) women have the highest prevalence of both obesity and frailty. In academic, expert- led interventions, obese, frail, older individuals both lost weight and improved their physical function. However, because of high personnel costs and n…
JEFF T HUTCHINS · INHALON BIOPHARMA, INC. · 2024 · $1,024,942 — Project Summary Human metapneumovirus (MPV) is the second leading cause of lower respiratory tract infections (LRTI) in infants and young children, and a major cause of respiratory illness among the immunocompromised and the elderly. Unfortunately, there is currently no effective therapy or vaccine…
NAIM M MAALOUF · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $479,998 — Project Summary: Urinary Stone Disease (USD) is an increasingly prevalent and highly recurrent condition associated with major morbidity at a rising cost to society. Thus, improved management can significantly reduce its health burden. Increasing fluid intake is recommended to all USD patients. Howe…
KAREN M RIDGE · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $2,662,883 — PROJECT SUMMARY_OVERALL Recovery from viral pneumonia is a clinically important yet understudied process. Severe influenza A virus and severe acute respiratory syndrome coronavirus 2 cause severe viral pneumonia, which damages the lower respiratory tract to induce acute respiratory distress syndrome…
Priyamvada Acharya · DUKE UNIVERSITY · 2024 · $672,175 — Structural characterization of Fab-dimerized glycan-reactive antibodies that neutralize HIV-1 A glycan shield covers the HIV-1 envelope (Env) limiting antibody access to broadly neutralizing antibody (bnAb) epitopes. 2G12 had for long been the only example of a HIV-1 bnAb that interacts solely with…