Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
TIMOTHY W. BICKMORE · TUFTS MEDICAL CENTER · 2024 · $648,684 — Universal Human Papillomavirus (HPV) vaccination would significantly decrease cervical, vaginal, vulvar, anal, and oral cancers, and reduce racial disparities in these cancers. However, HPV vaccination rates for U.S. adolescents of all races, ethnicities, and income levels remain far below national …
David Jackson · CERIA THERAPEUTICS, INC. · 2024 · $1,216,721 — SUMMARY Acute respiratory distress syndrome (ARDS) accounts for 10% of ICU admissions worldwide, with a mortality as high as 46%. ARDS incidence has risen dramatically during the COVID-19 pandemic. Despite improvements in critical care and early detection of lung injury, the management of ARDS rema…
Beatriz MA Fontoura · VANDERBILT UNIVERSITY · 2024 · $857,199 — The global COVID-19 pandemic caused by the SARS-CoV-2 outbreak underscores the need for understanding viral-host interactions that impact host gene expression and antiviral responses. A critical virulence factor of coronaviruses is the nonstructural protein 1 (Nsp1). We uncovered a previously unknow…
Kristian Michael Forbes · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · 2024 · $759,802 — PROJECT SUMMARY The COVID-19 pandemic has reinforced the significance of emerging infectious diseases for human health and security. Bats have been associated with high-profile viral emergence events, including SARS-CoV-2 (the causative agent of COVID-19), ebolaviruses, and a variety of zoonotic and…
Raiees Ahmad Andrabi · UNIVERSITY OF PENNSYLVANIA · 2024 · $722,284 — PROJECT SUMMARY/ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus identified at the end of 2019, has led to the current global pandemic. The SARS-CoV-2 virus belongs to the subgenus sarbecovirus of the genus betacoronavirus, the genus from which two SARS-CoV-…
Guillermo Prado · UNIVERSITY OF MIAMI CORAL GABLES · 2024 · $153,533 — PROJECT SUMMARY Sexual minority youth (SMY) in general, and Hispanic sexual minority youth in particular (HSMY), report higher levels of drug use and depressive symptoms, compared to their heterosexual and sexual minority peers. Moreover, negative health outcomes (e.g., drug use) are even higher for…
Elizabeth Gross Cohn · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $226,727 — ABSTRACT: Despite medical advances in treating chronic diseases and epidemiological findings identifying risk factors for chronic diseases, there remain major persistent health disparities driven by the Social Determinants of Health (SDoH). We have come together to address these disparities through …
KING-WAI YAU · JOHNS HOPKINS UNIVERSITY · 2024 · $409,375 — The long-term objective of this proposal is to understand in quantitative detail the cAMP- and Ca2+-signalings in sensory transduction by olfactory receptor neurons (ORNs). We shall focus on the canonical olfactory-transduction mechanism in the vertebrate main olfactory epithelium. This mechanism in…
Natalie Kreitzer · UNIVERSITY OF CINCINNATI · 2024 · $171,007 — Project Description / Abstract: My long-term career goal is to improve caregiver and patient dyad outcomes by developing family- centered psychosocial interventions that enhance education, support, and skill-building in caregivers of moderate to severe traumatic brain injury (msTBI) survivors. The …
Shikhar Mehrotra · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2024 · $440,560 — ABSTRACT Recent preclinical studies have shown that different subsets of both helper CD4+ T helper (Th) cells and CD8+ T cytotoxic (Tc) cells hold promise for clinical use in adoptive cell therapy (ACT) protocols. Importantly, T helper cell subsets with the ability to secrete IL-17 (Th17) have been …
Ryan D Bradley · NATIONAL UNIVERSITY OF NATURAL MEDICINE · 2024 · $1 — The T90/R90 Building Research across Inter-Disciplinary Gaps (BRIDG) Complementary and Integrative Health (CIH) Postdoctoral Clinical Research Training Program is a partnership between the University of Washington (UW) in Seattle, WA, and the National University of Natural Medicine (NUNM) in Port…
Daniel Ruiz · EMORY UNIVERSITY · 2024 · $81,306 — PROJECT SUMMARY/ABSTRACT Knowing how environmentally-induced epigenetic alterations are established in the mammalian germline, transgenerationally inherited, and contribute to disease in the adult, can lead to a more complete understanding of pathophysiology as well as novel preventive care opportun…
HAMID RABB · JOHNS HOPKINS UNIVERSITY · 2024 · $561,996 — Project Summary /Abstract Acute kidney Injury (AKI) associated morbidity and mortality is a major clinical problem that involves multiple overlapping pathophysiological mechanisms. Recent observations from our team and others demonstrated that intestinal microbiota modulates AKI outcome, however the…
Licia Selleri · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $567,205 — PROJECT SUMMARY Human cleft lip with or without cleft palate (CL/P), the most common craniofacial birth defect, is caused by im- paired fusion of the facial prominences. During normal morphogenesis, the frontonasal and maxillary promi- nences fuse at a three-way seam, the lambdoidal junction (l), to…
Richard D'Aquila · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $1,364,656 — Modified Project Summary/Abstract Section The broad, long-term mission of the Third Coast Center for AIDS Research (TC CFAR) is to use our interdisciplinary collaborations to power transformational advances across the translational spectrum from discovery to implementation of effective intervention…
Lisa Linnenbrink-Garcia · MICHIGAN STATE UNIVERSITY · 2024 · $408,380 — Project Summary Many students enter college with an interest in studying science, but ultimately pursue other majors. Others graduate with a science major, but fail to enter or remain in the biomedical workforce. The many pathways out of science contribute to shortages in the biomedical workforce, p…
Laurel Anne Monticelli · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $809,496 — PROJECT SUMMARY In the US alone, asthma affects approximately 24 million individuals, 6 million of whom are children under the age of 18, and is responsible for over 3,000 deaths annually1,2. A population of immune cells, called group 2 innate lymphoid cells (ILC2s), are integral in driving lung inf…
Sterling M McPherson · WASHINGTON STATE UNIVERSITY · 2024 · $529,622 — PROJECT SUMMARY/ABSTRACT Together, tobacco and alcohol kill more than half a million people in the United States every year, making co- addiction to these substances the leading cause of preventable death. We propose a contingency management (CM) paradigm based on point-of-care urine tests that meas…
Elizabeth P Henske · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $368,893 — Abstract Tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by germline loss-of-function mutations in TSC1 or TSC2. Renal disease, which includes cysts, angiomyolipomas, and renal cell carcinoma, is a major source of morbidity and mortality for both children and adults with TS…
Curt Scharfe · YALE UNIVERSITY · 2024 · $478,960 — Abstract: Newborn screening (NBS) using tandem mass spectrometry (MS/MS) has transformed our ability to identify and provide early, lifesaving treatment to infants with inborn errors of metabolism. While MS/MS screening identifies most affected babies, it is accompanied by frequent false-positive re…