Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Rizia Bardhan · IOWA STATE UNIVERSITY · 2024 · $266,335 — Project Summary/Abstract: Inhibitors of the PD-1/PD-L1 axis has been successful across multiple diseases. However, only a small subset of patients respond to these regimen and identifying patients likely to benefit from these therapies remains challenging. Current clinical standard relies on histopa…
Audrey Claire Drotos · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $20,908 — Abstract Natural sounds contain rapid fluctuations in the amplitude envelope, and detecting these changes is an im- portant task of the auditory system. Early auditory structures such as the cochlear nucleus primarily encode amplitude modulations (AMs) in sound by phase locking their firing to the A…
Henry Yin · DUKE UNIVERSITY · 2024 · $389,043 — Project Summary The parafascicular nucleus is a major nucleus in the so-called intralaminar group. Although it is traditionally considered part of the reticular activating system and thought to play a role in arousal and attention, its contributions to behavior are still poorly understood. Much of t…
Sara Lustigman · NEW YORK BLOOD CENTER · 2024 · $719,415 — PROJECT ABSTRACT Infectious diseases are a major cause of morbidity and mortality in the expanding older population. While vaccines are efficient measures to prevent infections, a critical problem is that aging-associated changes in the immune system lead to decreased immunogenicity and clinical eff…
Theodore George Drivas · UNIVERSITY OF PENNSYLVANIA · 2024 · $166,860 — PROJECT SUMMARY Rare genetic defects of the primary cilium can cause a number of phenotypically-overlapping Mendelian syndromes, known as ciliopathies. Intriguingly, many ciliopathy patients show signs of impaired glucose homeostasis, with accumulating evidence suggesting that insulin receptor must …
Neir Eshel · STANFORD UNIVERSITY · 2024 · $193,501 — Aggression—acting with the intent to inflict harm—is a universal component of social behavior, and all too often the grim subject of the daily news. One of the most reliable triggers of aggression is frustration, or failing to achieve an expected reward. This state can be adaptive, energizing behavi…
VIRGINIA Chih-Yi SUN · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · 2024 · $746,773 — PROJECT SUMMARY The overarching goal of this five-year grant proposal, submitted on behalf of the Beckman Research Institute of City of Hope and the University of California, Riverside, in response to RFA-CA-19-035, is to test the efficacy of an advance-practice nurse (APRN)-driven telehealth Surviv…
Jeffrey W Ruberti · NORTHEASTERN UNIVERSITY · 2024 · $505,592 — Project Summary The cornea and sclera are the principal load bearing members in the tough fibrous ocular tunic which we consider to be an integrated mechano-biological structure. During development, the shape of the eye has been tuned to conform to a specific mechanical environment through a long ti…
Mary Kathryn Grabowski · JOHNS HOPKINS UNIVERSITY · 2024 · $661,316 — PROJECT SUMMARY Globally, new HIV infections are concentrated in eastern and southern Africa where they are largely acquired by women outside of known key populations. Identifying African women at high risk for HIV acquisition and successfully engaging them in HIV prevention services, particularly p…
GIAN-PAOLO DOTTO · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $462,800 — SUMMARY Field cancerization is a major clinical condition resulting from combined keratinocyte and dermal fibroblast alterations. Identification of regulatory molecules to target alterations of both cell types is of substantial interest. We propose that the nuclear kinase ULK3 is one such a molecule…
Pankaj Arora · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2024 · $725,178 — PROJECT SUMMARY Black individuals have a higher prevalence of insulin resistance and are more likely to have cardiometabolic diseases, which is associated with an increased risk of mortality. The reasons for the increased insulin resistance in Blacks are incompletely understood. The natriuretic pept…
Sarah Cohen · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $571,695 — ABSTRACT Alzheimer’s disease (AD) is one of the predominant causes of disability and dependency among older people, and the sixth leading cause of death in the United States. Late-onset AD is the most common form, with more than 99% of AD cases occurring after age 65. The strongest genetic risk fact…
Ryan Daniel Sochol · UNIV OF MARYLAND, COLLEGE PARK · 2024 · $652,325 — Project Summary: Cerebral aneurysms are estimated to be prevalent in 3–7% of the general population—with cases increasing by more than 5% each year—resulting in ~500,000 deaths annually. Minimally invasive neurosurgery typically represents the best surgical option for treating unruptured aneurysms …
Lalit Deshmukh · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $197,500 — Project Summary. Human insulin-degrading enzyme (IDE) is a highly conserved dimeric zinc metalloprotease that hydrolyzes various peptide substrates, such as insulin, amyloid-β (Aβ), glucagon, amylin, and HIV-1 p6. It is implicated in several physiological and pathological processes, including insuli…
Jorge Henao-Mejia · UNIVERSITY OF PENNSYLVANIA · 2024 · $645,276 — PROJECT SUMMARY Group 1, 2, and 3 innate lymphoid cells (ILC1, ILC2, and ILC3) are immune effector cells that contribute to tissue homeostasis and host defense against nearly all classes of pathogens, but their dysregulation also play key roles in prevalent diseases such as cancer, obesity, asthma, …
PIETER C DORRESTEIN · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $721,727 — Project Summary/Abstract The Microbiota-Diet-Host interactions are critical to the balance of health and disease. Understanding this axis will be important to the development of nutritional precision medicine. Although there are some important discoveries where microbes make molecules that dramatic…
Oliver I Fregoso · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $607,081 — PROJECT SUMMARY Approximately 40 million people are currently infected by HIV, with an additional 1.7 million people newly infected each year. While only a single person has been functionally cured of HIV, advances in antiretroviral therapy (ART) have drastically decreased AIDS-related illnesses an…
MAE O GORDON · WASHINGTON UNIVERSITY · 2024 · $198,322 — Project Summary This application is for secondary analyses to determine the long-term effect of treatment, clinical and demographic factors on vision-related quality of life (VRQOL) in the Ocular Hypertension Treatment Study (OHTS) cohort. This application is timely because the US Preventative Servi…
Siqi Liu · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $239,197 — PROJECT SUMMARY/ABSTRACT Skin has a remarkable ability to heal wounds through re-epithelialization, a repair process fueled by adult stem cells residing in the epidermis and hair follicles. Following injury, wound-edge keratinocytes proliferate and migrate to initiate wound closure, which is accompa…
Shachi Tyagi · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $456,832 — PROJECT SUMMARY Prevalent, morbid, and costly (≥$83 billion/year), urgency urinary incontinence (UUI) is a major problem, especially for older women. With etiology usually ascribed to bladder spasms, the available therapies are bladder-targeted and provide only a modest benefit. Despite inadequate r…