Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Sarah AM Cuddy · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $193,687 — Project Summary Heart failure (HF) affects over 5 million adults over the age of 65. Cardiac transthyretin amyloidosis (ATTR-CM) is a cause of HF in ~10% of older adults and leads to significant morbidity and mortality. Musculoskeletal manifestations are common in ATTR-CM and occur 5-10 years prior …
Mark D Bevan · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $548,208 — Project Summary While the bradykinetic and akinetic symptoms of Parkinson’s disease (PD) are clearly linked to the degeneration of substantia nigra dopaminergic (SN DAergic) neurons1-3, the mechanisms that underlie the emergence and escalation of basal ganglia circuit and motor dysfunction remain po…
Jianping Fu · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $164,992 — Project Summary Modeling NDE1 function in dysregulated brain development using a microfluidic CNS model Development of the vertebrate central nervous system (CNS) begins with the formation of neural tube (NT) and its regional patterning to generate the forebrain, midbrain, hindbrain, and spinal cord…
FRANCK POLLEUX · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $1,196,738 — ABSTRACT Over the past two decades, my laboratory has focused on the identification of novel molecular and cellular mechanisms underlying the development, maintenance (Project 1) and human-specific evolution (Project 2) of cortical circuits. In Project 1, we propose to study the role of novel molecu…
Jennifer Beth Levin · CASE WESTERN RESERVE UNIVERSITY · 2024 · $714,215 — PROJECT SUMMARY While cardiovascular disease remains a significant burden in the U.S., effects are particularly pronounced in people with mental disorders such as bipolar disorder (BD). Medical complications and early mortality in those with BD and hypertension is often associated with poor medicat…
Metin Nafi Gurcan · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $605,311 — ABSTRACT Diseases of the ear, particularly acute otitis media (AOM) and middle ear effusions, are the most commonly treated childhood pathologies. The financial burden of ear disease is estimated at more than $3.2 billion per year. Because ear diseases are common, a significant problem is over-diagn…
Xiaoyan Zheng · GEORGE WASHINGTON UNIVERSITY · 2024 · $19,230 — Project summary/abstract The establishment of left-right (LR) asymmetry is a critical event required for the correct positioning of internal organs. Defects in human LR axis formation cause birth defects of the heart, vasculature, lungs, and intestinal tract. The gene network contributing to the gen…
Alexander Ploss · PRINCETON UNIVERSITY · 2024 · $598,764 — Project summary Coinfection with HBV and HIV-1 is common, and HIV coinfection can exacerbate progression of viral hepatitis and accelerate liver disease progression. In fact, endstage liver diseases, including fiboris/cirrhosis and hepatocellular carcinoma, have become the most common causes of deat…
Miho Iijima · JOHNS HOPKINS UNIVERSITY · 2024 · $516,338 — Summary (30 lines) Our research program aims to understand how cells control intracellular signaling to respond and adapt to their environments. We will focus on three processes: Project 1 will examine the chemotactic migration of cells in extracellular chemical gradients, Project 2 will look at DNA…
Brenice Duroseau · JOHNS HOPKINS UNIVERSITY · 2024 · $45,399 — PROJECT SUMMARY Cisgender Black women in the United States (US) shoulder a significant burden of HIV and sexually transmitted infections (STIs), with persistent disparities driven by stigma, implicit bias, and structural barriers. The disproportionate impact of HIV/STIs among Black women in the US u…
Charles KF Chan · STANFORD UNIVERSITY · 2024 · $500,000 — PROJECT SUMMARY/ABSTRACT This proposal’s objective is to determine whether changing the signaling patterns between the skeletal stem cells (SSCs) and hematopoietic stem cells (HSCs) can treat atherosclerotic cardiovascular disease (ASCVD). Previous data from our lab suggests that aging SSCs can caus…
JUNG-MO AHN · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · 2024 · $283,533 — Project Summary/Abstract Ovarian cancer (OCa) is the deadliest of all gynecologic cancers in the United States. Despite initial response to chemotherapy, most OCa patients become resistant and progress to metastatic disease. Long-term prognosis of OCa is dismal, and new therapeutic strategies are de…
Michelle Elizabeth Farkas · UNIVERSITY OF MASSACHUSETTS AMHERST · 2024 · $382,707 — Project Summary/Abstract Circadian clocks are time-tracking systems that allow organisms to adapt to the time of day, and drive many cellular functions. Their alteration can lead to various diseases, including cancer, heart disease, and metabolic disorders. In this work, we propose development of a …
Rohan Palanki · UNIVERSITY OF PENNSYLVANIA · 2024 · $36,681 — PROJECT SUMMARY Congenital lung diseases, such as inherited surfactant protein syndromes, cystic fibrosis, and alpha-1 antitrypsin deficiency, are a significant source of pediatric morbidity and mortality. Treatment options for neonatal patients with lung disorders that present with respiratory fail…
Alexander Sobolevsky · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $398,780 — PROJECT SUMMARY AMPA-subtype ionotropic glutamate receptors mediate fast signaling between neurons and contribute to high cognitive processes. Since AMPA receptors are also implicated in numerous neurological disorders, including Alzheimer’s disease, amyotrophic lateral sclerosis, epilepsy, and isch…
Kuang Shen · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2024 · $418,750 — Project Summary / Abstract Cells need to sense the nutrient availability to adjust their survival strategy. In eukaryotic cells, the mechanistic Target of Rapamycin Complex 1 (mTORC1) is a key regulator of cell growth and proliferation. Upon activation in a nutrient-rich environment, mTORC1 trigger…
Jennifer J Kohler · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $525,698 — Summary/abstract This research program focuses on uncovering the biological roles of glycoconjugates. Part of this effort is devoted to the development of chemical biology tools for glycoscience research. In the past, we have developed photocrosslinking sugar analogs that can be incorporated into ce…
EDWARD M. GREENFIELD · INDIANA UNIVERSITY INDIANAPOLIS · 2024 · $419,487 — ABSTRACT Age-related trabecular bone loss begins in young adulthood and leads to increased rates of osteoporosis and fractures in elderly men and women. It is fastest in vertebrae, where it is ~2-fold faster in women than in men, and then accelerates in post-menopausal women. Stimulation of cAMP/PKA…
Nikki Cheng · UNIVERSITY OF KANSAS MEDICAL CENTER · 2024 · $345,567 — ABSTRACT About 50,000 cases of ductal carcinoma in situ (DCIS) are diagnosed in the US every year, making DCIS the most common type of non-invasive breast cancer diagnosed in women. Up to 20% of all patients will experience disease recurrence accompanied by invasive ductal carcinoma (IDC). Current c…
Makayla Leroux · UNIVERSITY OF CONNECTICUT STORRS · 2024 · $46,476 — PROJECT SUMMARY Assembly of dsDNA viruses, including the tailed bacteriophages, herpesviruses, and adenoviruses, is a highly coordinated process involving a series of protein interactions that lead to the formation of an infectious virion. The central goal of this research is to achieve a detailed m…