NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Seth Jacob PRINS · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $716,003 — PROJECT SUMMARY: Over 10 million students in the US attend schools with police but no counselor, nurse, psychologist, or social worker. Yet, more than a third of the low proportion of adolescents who receive the substance use treatment they need (6%) access it only at school; they are disproportiona…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Cory Matthew Root · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $395,000 — Project Summary The brain translates internal representations of the external world into appropriate behaviors. Elucidation of how sensory information is propagated through hierarchical systems is an important step towards understanding how the brain instructs behavior. The sense of smell is a tract…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Anna K Majewska · UNIVERSITY OF ROCHESTER · 2024 · $308,995 — Remodeling of cortical networks by visual experience during development relies on rapid changes in synaptic structure and function. The exquisite specificity of these activity-driven synaptic changes begs the question of how they are implemented. Surprisingly we have recently shown that microglia, t…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Yoshihiro Izumiya · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $532,446 — Deregulation of genome interactions through mutations at regulatory elements or mutation of responsible cellular nuclear enzymes result in multiple disorders. Although the significance of proper genomic-genomic interactions has been seen from disease phenotypes, the underlying molecular mechanisms o…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
ROBERT E GERSZTEN · BETH ISRAEL DEACONESS MEDICAL CENTER · 2024 · $512,548 — Project Summary/Abstract Regular exercise improves numerous metabolic and cardiovascular health traits and prevents or delays the development of cardiometabolic disease. Despite the pleiotropic health effects of exercise, there are substantial inter-individual differences in the cardiometabolic resp…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
TAMARA J. PHILLIPS · OREGON HEALTH & SCIENCE UNIVERSITY · 2024 · $1,533,881 — Project Summary This renewal application of the Portland Alcohol Research Center (PARC) proposes funding for Years 26 to 30. Over the years of its existence, the number of Portland investigators engaged in alcohol research has increased and their associated research efforts and other mutually suppor…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Julie Christine Lauffenburger · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $651,149 — ABSTRACT Hypertension affects one in three US adults, yet only 50% have their blood pressure adequately controlled. Hypertension is twice as prevalent in black adults than non-Hispanic whites; consequently, blacks are 2 to 3 times more likely to die of hypertension-related heart disease than their w…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Melissa A Cunningham · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2024 · $407,072 — Systemic lupus erythematosus (SLE) is one of many autoimmune diseases that disproportionately affects females. Although many risk factors for lupus are identified: >170 genes including GPR174, myriad environmental exposures, and aberrant X chromosome inactivation, none of these sufficiently explain …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Adam G Carter · ALLEN INSTITUTE · 2024 · $3,611,067 — Summary, Overall (Thalamus in the middle: computations in multi-regional neural circuits) This collaborative project aims to uncover the logic of signal routing from subcortical areas to the frontal cortex through the thalamus. The frontal cortex displays rich patterns of neural activity, which can …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
DION KAI DICKMAN · UNIVERSITY OF SOUTHERN CALIFORNIA · 2024 · $348,898 — Homeostatic signaling systems operate at synapses to enable flexible yet stable information transfer in the nervous system. Defects in homeostatic signaling contribute to seizures, excitotoxicity, cognitive decline, and neurodegeneration. Although much has been learned in recent years about the expr…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
TIMOTHY A SPRINGER · BOSTON CHILDREN'S HOSPITAL · 2024 · $719,617 — Abstract. Integrins are cell surface receptors that mediate numerous interactions between cells and their environment. Binding of integrin α5β1 to its ligand fibronectin in the extracellular matrix plays fundamental roles in cellular adhesion and differentiation. In blood cells these interactions me…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Sabine Petry · PRINCETON UNIVERSITY · 2024 · $434,161 — Project Summary Cell division is orchestrated by the mitotic spindle, composed of hundreds of thousands of microtubules (MT). Since the discovery of the MT building block tubulin 50 years ago, scientists have puzzled over how the mitotic spindle assembles via MTs and executes chromosome segregation …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
BRIAN WICKES · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · 2024 · $452,461 — ABSTRACT Diagnosing fungal infections faces a number of challenges including a decline in expertise needed for identifying fungi and a reduced number of instruments and assays specific for fungal identification compared to bacteria and viruses. These problems are exacerbated by the fact that patient…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
CARROLL ANN TROTMAN · OHIO STATE UNIVERSITY · 2024 · $628,035 — Patients with facial paralysis have an obvious facial disability that includes facial disfigurement and impairment in soft tissue movements, particularly in facial expressive behaviors. Management requires a tailored and, at times, disparate approach to correct the facial disability ranging from non…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Cassie S Mitchell · GEORGIA INSTITUTE OF TECHNOLOGY · 2024 · $366,688 — Project Summary/Abstract The Laboratory for Pathology Dynamics was founded on the principle that pathology is multifactorial, multi- scalar, and driven by complex interacting dynamics. This proposal builds and applies new predictive medicine technology that enables multifactorial, multi-scalar data …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Na Zhao · MAYO CLINIC JACKSONVILLE · 2024 · $742,112 — PROJECT SUMMARY The major goal of this proposal is to address the dynamic role of TREM2-mediated microglial function in brain aging and during different stages of the pathological development of Alzheimer’s disease (AD). TREM2 is a microglial specific gene with several of its rare variants associat…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Lionel B Ivashkiv · HOSPITAL FOR SPECIAL SURGERY · 2024 · $379,852 — Activated synovial macrophages (M[phi]s) are major producers of pathogenic cytokines, and play a key role in RA pathogenesis. The long term goals of this project are to understand mechanisms that regulate the balance between activating and feedback inhibitory signaling pathways that are activated in…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Chang-Gyu Hahn · THOMAS JEFFERSON UNIVERSITY · 2024 · $609,276 — Project Summary (Significance) Multiple lines of evidence have implicated mGluR5 signaling for the pathophysiology and treatment of schizophrenia; yet possible dysregulation of mGluR5 signaling and their pathophysiologic roles are presently unknown. Recently, we found direct evidence for reduced mGl…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
LAURA ELENA ODELL · UNIVERSITY OF TEXAS EL PASO · 2024 · $453,040 — ABSTRACT Tobacco use remains a major public health and economic concern, particularly in women who are more susceptible to the long-term consequences of nicotine exposure. Clinical evidence has revealed that stress produced by nicotine withdrawal can be intensified by fluctuations in gonadal hormon…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
JILL M GOLDSTEIN · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $2,400,001 — OVERALL SUMMARY. Major depressive disorder (MDD) topped heart disease as the number one cause of disability worldwide, and women have twice the risk of men. MDD is associated with abnormalities in the stress response circuitry, areas that are among the most sexually dimorphic in the brain. These are…