Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Tian Ge · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $732,244 — Impaired higher-order cognition is well-documented in different forms of neuropsychiatric illness, present in unaffected relatives, often presumed to underlie behavioral symptoms, and associated with functional outcome. Cognition is thus exceedingly relevant to studies of the etiology and trajectory…
Samuel Brill · COLORADO STATE UNIVERSITY · 2024 · $48,974 — Project Summary This proposal aims to train a dual-degree, DVM-PhD student for a career as a lab animal veterinarian and independent scientist. The research outlined in this proposal will develop a pre-clinical platform to evaluate CAR-T therapy in a canine model. Chimeric antigen receptor (CAR)-T c…
Dritan Agalliu · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $540,496 — PROJECT SUMMARY Traumatic brain injury (TBI) is one of the leading causes of death and disability worldwide due to its heterogeneity and complex mechanisms of pathogenesis. Clinical outcomes following TBI are determined by the nature and severity of the primary injury as well as activation of the pe…
SEUNGHEE CHA · UNIVERSITY OF FLORIDA · 2024 · $598,932 — ABSTRACT Through our multidisciplinary clinical and research collaboration, we have established a rare cohort of children and adolescents who fulfilled the 2016 adult Sjögren’s disease (SjD) criteria (namely, cSjD for childhood Sjögren’s disease). Since autoimmune SjD typically affects elderly femal…
Stephanie Manasse · DREXEL UNIVERSITY · 2024 · $664,491 — ABSTRACT Overweight/obesity (OW/OB) affects 14 million adolescents in the United States, disproportionately affecting girls and racial/ethnic minorities, increasing their risk of cardiovascular disease and type 2 diabetes. Behavioral weight loss interventions are the foundation of obesity treatment …
Brendan Adkinson · YALE UNIVERSITY · 2024 · $33,892 — PROJECT SUMMARY Nearly one-fifth of the Unites States population resides in a rural region, and approximately one-fifth of those residents suffers from a mental illness. While these rates of mental illness are similar to urban areas, individuals living in rural regions face a disproportionate burde…
Yolanda Sanchez · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · 2024 · $2,300,943 — ABSTRACT: The overarching goal of the University of New Mexico Comprehensive Cancer Center (UNMCCC) Cancer Research Training and Education Coordination Core (CRTECC) is to prepare a diverse group of trainees to conduct cancer research in the context of laboratory, clinical, and community settings …
CHAD A. MIRKIN · NORTHWESTERN UNIVERSITY · 2024 · $490,839 — PROJECT SUMMARY/ABSTRACT This research will utilize spherical nucleic acid (SNA) nanostructures to develop effective, structure-informed vaccines for advanced melanoma. Traditional treatments (i.e. chemotherapy or radiation) are less successful for melanoma because of difficulties in discerning mela…
Neelendu Dey · FRED HUTCHINSON CANCER CENTER · 2024 · $1,577,081 — SUMMARY Colorectal cancer (CRC) affects ~145,000 people/year in the US and is the 3rd most common cause of cancer related deaths. CRC arises from early lesions that are pre-cancerous; these early lesions are colon adenomas and serrated sessile lesions (SSL). Colon adenomas account for 80-85% of the …
Alan Teo · PORTLAND VA MEDICAL CENTER · 2024 — Background: Suicide is an urgent public health crisis, and transitioning Veterans (those who have recently separated from the military) are a high-risk group for suicide. A key component to advancing suicide prevention efforts among at-risk Veterans is to address low levels of help-seeking and engag…
Christie Befort · UNIVERSITY OF KANSAS MEDICAL CENTER · 2024 · $2,294,953 — PROJECT SUMMARY/ABSTRACT: OVERALL COBRE on Implementation Science & Equity Shrinking the time lag for translating research evidence into clinical practice would improve health outcomes across multiple domains and reduce costs to society. Until recently, however, clinical research has devoted little …
LORRAINE J GUDAS · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $434,366 — Abstract Despite intensive treatments that often combine surgery, chemotherapy, and radiation, patients with head and neck squamous cell carcinomas (HNSCCs), including oral cavity and esophageal squamous cell carcinomas (OCSCCs & ESCCs), have a long-term survival rate of only 15-40%. Among the reaso…
Susan Mazanec · CASE WESTERN RESERVE UNIVERSITY · 2024 · $440,890 — Project Summary/Abstract: Patients with head and neck, lung, esophageal, rectal, and anal cancers typically undergo rigorous, intense, combined-modality treatment (radiation, surgery, and/or chemotherapy) and experience high symptom burden, functional impairment, and complex psychosocial issues. Pos…
BRUCE A. BERKOWITZ · WAYNE STATE UNIVERSITY · 2024 · $1,086,200 — Therapeutically delaying the progressive decline in cognition in patients with Alzheimer’s disease (AD) would transform AD into a manageable morbidity, a goal that has not been achieved using drugs targeted to β-amyloid (Aβ) plaque deposition. Accumulating results indicate that cognitive loss (linke…
Erik D. Storholm · SAN DIEGO STATE UNIVERSITY · 2024 · $630,223 — SUMMARY/ABSTRACT Transgender and non-binary (TGNB) persons experience intimate partner violence (IPV) at alarming rates twice that of their cisgender peers. Prior work has linked IPV to sexual risk behavior and increased risk for HIV seroconversion among TGNB, but less is known about the impact of I…
John Ross Rizzo · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $264,010 — PROJECT SUMMARY/ABSTRACT Visual impairment causes significant losses to mobility, independence, and quality of life, contributing to elevated rates of anxiety, depression, and physical injuries, inclusive of mechanical trips and falls. These challenges are compounded in complex urban environments, …
MARILYN S. ALBERT · JOHNS HOPKINS UNIVERSITY · 2024 · $1,309,997 — Project Summary/Abstract: Small-vessel-related vascular contributions to cognitive impairment and dementia (VCID) represent the second leading cause of cognitive dysfunction in older individuals. However, quantitative biomarkers indexing key vascular processes related to VCID that are suitable for …
Jonathan Greenberg · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $157,939 — Project Summary This K23 proposal details a comprehensive 5-year training program that will support the candidate’s transition toward an independent clinical research career focused on the development and rigorous testing of mind-body interventions with an emphasis on prevention of transition from a…
Emmanuel J Mignot · STANFORD UNIVERSITY · 2024 · $623,609 — Abstract Novel neuroimmune disorders defined by the presence of autoantibodies in plasma and/or CSF have recently been discovered, most often first described in the context of paraneoplastic syndromes, only later to be also found unassociated with tumors. These include limbic encephalitis (e.g., ant…
Krzysztof Kiryluk · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $805,207 — PROJECT SUMMARY Chronic kidney disease (CKD) is a common complex condition associated with high morbidity and mortality, with a prevalence estimated at 13% in the U.S. that continues to increase annually. The etiology of CKD is complex, with both genetic – including monogenetic and polygenic – and e…