Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Jeffrey Wade Brown · WASHINGTON UNIVERSITY · 2024 · $165,062 — PROJECT SUMMARY / ABSTRACT This application proposes a five-year research career development program focused on determining how glycosylation epitopes expressed during metaplasia and cancer contribute to these clinically significant cellular transformations. The applicant, Jeffrey W. Brown, M.D., P…
Krishanu Ray · UNIVERSITY OF MARYLAND BALTIMORE · 2024 · $386,250 — Certain broadly HIV-neutralizing antibodies (bnAbs) are being actively investigated as agents for HIV/AIDS treatment, functional cure and/or prevention. These bnAbs are classified according to cognate epitopes clusters on the HIV envelope (Env). Rigorous preclinical studies evince several potential …
LAWRENCE F BRASS · UNIVERSITY OF PENNSYLVANIA · 2024 · $969,764 — Hematology Research Training Program (T32 HL-07439) PI/PD: Brass, Lawrence F. Abstract The Hematology Research Training Program (HRTP) at the University of Pennsylvania was established in the mid-1970’s. It has received NHLBI T32 funding since 1978 and to date it has provided support for 179 predoct…
MICHAEL R. BOTCHAN · UNIVERSITY OF CALIFORNIA BERKELEY · 2024 · $537,835 — PROJECT SUMMARY Our long-term goal is to define the molecular mechanisms by which DNA replication is initiated and regulated in metazoans. Cells rely on two AAA+ ATPases, ORC and Cdc6, along with a third factor, Cdt1, to load a latent helicase (the Mcm2-7 complex) as a double hexamer onto replicatio…
JEROLD CHUN · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · 2024 · $929,705 — PROJECT SUMMARY/ABSTRACT We have identified somatic gene recombination (SGR) in neurons of the human brain, with particular relevance to sporadic Alzheimer’s disease (SAD) (Nature 563, 639-645 (2018)). This discovery represents a new and functionally significant aspect of genomic mosaicism (eLife;4:…
Garret D Stuber · UNIVERSITY OF WASHINGTON · 2024 · $455,615 — The neural circuitry that encodes and mediates the establishment of cue-reward associations, an adaptive process that is essential for survival, likely becomes dysfunctional in neuropsychiatric illnesses such as drug addiction. While the full encoding of cue-reward associations require a distributed…
Rasheed Adebayo Gbadegesin · DUKE UNIVERSITY · 2024 · $658,609 — Nephrotic syndrome and other glomerular diseases are major causes of chronic kidney diseases world-wide. The molecular mechanisms of NS are not completely known, and this major gap in knowledge is an impediment to treating patients with NS and developing new treatments. A more complete understanding…
SHARON K. INOUYE · HEBREW REHABILITATION CENTER FOR AGED · 2024 · $805,402 — Delirium, an acute disorder of attention and cognition, is a common, life-threatening, and costly condition for older adults with strong links to Alzheimer’s Disease and Related Dementias (ADRD). In 2015, responding to RFA-AG-16-009, we created the Network for Investigation of Delirium: Unifying Sci…
Evan Snitkin · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $705,833 — Whole-genome sequencing (WGS) has transformed our ability to track the spread of pathogens in healthcare settings. With the ability to identify patients linked by transmission has come the capacity to determine with high confidence the role of certain hospital locations, contaminated infrastructure,…
GREGORY E. SIMON · KAISER FOUNDATION RESEARCH INSTITUTE · 2024 · $818,413 — Half of people starting antidepressant medication experience no significant improvement with the first medication prescribed, leading either to discouragement and dropout or months of trial-and-error. More accurately matching individuals with specific medications could significantly increase treatme…
David A Isaacs · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $176,796 — Project Summary / Abstract Candidate: David Isaacs, MD, MPH is Assistant Professor in the Department of Neurology at Vanderbilt University Medical Center. During his faculty tenure, he has demonstrated enthusiasm and aptitude for patient- centered research, with emphasis on non-motor aspects of move…
Rachel A Moses · DARTMOUTH-HITCHCOCK CLINIC · 2024 · $341,426 — Project Summary/Abstract Metoidioplasty and phalloplasty gender affirming surgeries (MaPGAS) are increasingly performed but remain high risk procedures that require patients to make complex decisions affecting future gender congruence, fertility, urinary, and sexual function. Prior studies demonstr…
Poulikos I Poulikakos · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $723,506 — Summary The RAS/RAF/MEK/ERK (RAS/MAPK) signaling pathway is an established driver of many cancers, commonly hyperactivated by genetic alterations in RAS or BRAF. RAF and MEK inhibitors (RAFi and MEKi) have been clinically successful in BRAF-mutant (BRAF-MUT) tumors, but their clinical efficacy in RA…
Angela Christine Hirbe · WASHINGTON UNIVERSITY · 2024 · $488,097 — Project Summary Neurofibromatosis type 1 (NF1) is a common neurogenetic cancer predisposition syndrome, affecting 1 in 3,000 individuals worldwide. While most of the tumors are benign neoplasms (neurofibromas, low-grade gliomas), 10-13% of patients will develop an aggressive sarcoma, termed a malign…
Kostandin Pajcini · UNIVERSITY OF ILLINOIS AT CHICAGO · 2024 · $405,490 — PROJECT SUMMARY Cells employ nanoscale mechanisms to secrete extracellular vesicles (EVs) that contain a variety of functional ligands on the lipid membrane. This mode of delivery offers an effective strategy to systemically activate membrane receptors over distance without a need for cell migration…
Emily O Wakefield · CONNECTICUT CHILDREN'S MEDICAL CENTER · 2024 · $129,828 — ABSTRACT Pain-related stigma is a significant and understudied psychosocial factor among adolescents with chronic widespread musculoskeletal pain (CWMP) that has been implicated in impaired health outcomes. The subjectivity of pain self-report increases the opportunity for an individual to experienc…
Aarti Mathur · JOHNS HOPKINS UNIVERSITY · 2024 · $820,224 — PROJECT SUMMARY Of the 400,000 older (age ≥55) adults living with end-stage renal disease (ESRD), 87% are cognitively impaired and 25% are subsequently diagnosed with dementia. Incident dementia in older ESRD patients is associated with a 1.5-fold higher risk of disability and 2-fold higher risk of …
Erin Anne Kaufman · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2024 · $199,481 — PROJECT SUMMARY/ABSTRACT Suicide is a global public health concern that marks an extreme along a spectrum of self-inflicted injury (SII) and is the leading cause of death among adolescents. Although we have evidence-based interventions for youth SII, mechanisms of change are underexplored, and suici…
Verginia Carmella Cuzon Carlson · OREGON HEALTH & SCIENCE UNIVERSITY · 2024 · $641,513 — PROJECT SUMMARY Fetal exposure to alcohol leads to a wide range of neurological deficits collectively termed fetal alcohol spectrum disorder (FASD). This prevalent neurodevelopmental disorder currently affects as many as 1-5% of school-aged children in the United States. Existing intervention strate…
Luis A Martinez-Lemus · UNIVERSITY OF MISSOURI-COLUMBIA · 2024 · $667,915 — PROJECT SUMMARY/ABSTRACT Vascular insulin resistance is a hallmark of type 2 diabetes (T2D) and dampening of insulin-induced vasodilation is its primary consequence. Notably, in T2D, reduced insulin-stimulated vasodilation and blood flow to tissues such as skeletal muscle significantly limits glucos…