Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Mark A Kay · STANFORD UNIVERSITY · 2024 · $701,277 — Adeno-associated viral vectors (rAAV) have shown promise in some liver-based clinical trials including hemophilia B. However, one of the limitations is the loss of the vector genomes during tissue growth and cell division limiting the duration of expression when treatment is initiated early in life.…
Johnny Le · UNIVERSITY OF CALIFORNIA-IRVINE · 2024 · $44,445 — PROJECT SUMMARY Type II diabetes takes a large toll on both individuals and society through morbidity and financial burden. Patients with diabetes are at risk of developing diabetic foot ulcers that are nonhealing and can lead to infections and amputations. The pathophysiology that underlies this im…
Mingli Liu · MOREHOUSE SCHOOL OF MEDICINE · 2024 · $355,000 — The current standard of care of surgery and radiochemotherapy for glioblastomas (GBM) is inadequate and has not resulted in improved prognosis. Accumulating evidences show that the failure of using current chemo (temozolomide, TMZ)- and radio- therapies to treat GBM and the resultant high tumor recu…
CHEN GU · OHIO STATE UNIVERSITY · 2024 · $521,130 — PROJECT SUMMARY Developing neuroprotective and repair strategies represents an urgent unmet need for treating inflammatory demyelinating disorders of the central nervous system (CNS) including multiple sclerosis (MS). Lesions in both MS patients and the MS mouse model, experimental autoimmune encep…
Chiung-Kuei Huang · TULANE UNIVERSITY OF LOUISIANA · 2024 · $426,069 — Project summary: The long-term goal of this project is to determine the role of TET1 in non-alcoholic fatty liver disease (NAFLD) development and progression. Several recent studies have suggested that the DNA methylation of specific genes, such as insulin growth factor-like protein 2 (IGFBP2), is h…
Amanda Marie Wilson · UNIVERSITY OF ARIZONA · 2024 · $145,041 — PROJECT SUMMARY/ABSTRACT (limit 30 lines of text) Cleaning and disinfection (C&D) activities pose work-related asthma (WRA) risks for nurses. C&D involves an inherent “risk-risk tradeoff”: increased C&D leading to increased WRA risks and simultaneous decreased occupational infection risks. Our preli…
Aras Nikodemas Mattis · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $669,949 — PROJECT SUMMARY/ABSTRACT This is a research grant application for a study being undertaken in the laboratory of Dr. Aras Mattis, a Scientist at the University of California, San Francisco (UCSF). This grant will provide support for the Mattis lab to conduct this research over the five-year term of …
Beth A Smith · CHILDREN'S HOSPITAL OF LOS ANGELES · 2024 · $585,327 — Project Summary It is crucial to understand how infants learn to progress from spontaneous movements into goal-directed, refined motor skills. Infant learning is the focus of early intervention programs, and the need for effective early intervention is great. Until we understand the mechanisms of de…
Amy Kogon · CHILDREN'S HOSP OF PHILADELPHIA · 2024 · $183,815 — PROJECT SUMMARY For youth with chronic kidney disease (CKD), cardiovascular disease (CVD) is a leading cause of morbidity and early mortality. Youth with CKD are less physically active than their healthy peers. They also have lower muscle strength, which may be a proxy for overall physical inactivit…
Alexander Wanless Smith · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2024 · $248,999 — PROJECT SUMMARY/ABSTRACT The US is in the midst of an opioid abuse and overdose epidemic. Oxycodone is one of the most prescribed analgesics, is the first opioid many people experience, and has physiochemical properties that allow it to accumulate in the brain at rates higher than other opioids, per…
Sarah Ann Flowers · WINIFRED MASTERSON BURKE MED RES INST · 2024 · $1,018,953 — Experimental data linking thiamine (vitamin B1) deficiency to Alzheimer’s disease (AD) inspired our clinical trial, which generated preliminary evidence that pharmacological thiamine produced by the drug benfotiamine provides clinical benefit. We hypothesize that pharmacological thiamine is protecti…
Jaime Lynn Speiser · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2024 · $111,087 — ABSTRACT My goal is to establish myself as an independent biostatistical researcher who develops and validates prediction models that are critical to identifying older adults at high risk of adverse health outcomes using novel machine learning methodology. My passion for developing prediction models…
Marvin Thomas Nieman · CASE WESTERN RESERVE UNIVERSITY · 2024 · $465,471 — PROJECT SUMMARY/ABSTRACT Venous thrombosis (VT) and its major complication, pulmonary embolism (PE), are often grouped together and called venous thromboembolism (VTE). VTE is a major health problem that affect nearly 600,000 people each year. The historical drivers of VTE are blood stasis, endothel…
Manuella Yassa · UNIVERSITY OF CALIFORNIA-IRVINE · 2024 · $256,243 — PROJECT SUMMARY Diversity is critical to innovation and the advancement of our society. Yet despite our best efforts as a nation, the United States has not been able to achieve STEM workforce diversity goals, which have been long attributed to the failure of the “academic pipeline” to recruit and re…
Xuefang Cao · UNIVERSITY OF MARYLAND BALTIMORE · 2024 · $750,705 — Project Summary Neurotransmitters and hormones serve as a link between the nervous and immune systems. Among them, norepinephrine and epinephrine are synthesized in the postganglionic neurons of the sympathetic nervous system and the adrenal medulla. Upon release, they engage the β2-adrenergic recep…
JAMES A. IMLAY · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · 2024 · $305,434 — Bacteriologists have proposed that numerous stresses are toxic to bacteria because they stimulate the intracellular production of superoxide and hydrogen peroxide. In most cases, no molecular mechanism has been determined, and none is self-evident. Many of these proposals are based upon data from re…
Ginny Ching-Yun Hsu · OREGON HEALTH & SCIENCE UNIVERSITY · 2024 · $166,058 — Project Summary/Abstract Bone tissue has high intrinsic regenerative potential, yet deficits in mesenchymal precursor numbers, function, or supportive tissues lead to non-healing bony defects – a significant clinical problem within and outside of the dental sciences. Mixed stromal populations termed…
Ashley M. Henneghan · UNIVERSITY OF TEXAS AT AUSTIN · 2024 · $193,768 — PROJECT SUMMARY/ABSTRACT Cancer-related cognitive impairments (CRCI) are some of the most distressing and burdensome effects of breast cancer and its treatment. When patient reported outcomes (PROs) are used, up to 75% of survivors report CRCI. Cognitive PROs are accessible, brief, and represent eve…
Rachel R Hardeman · UNIVERSITY OF MINNESOTA · 2024 · $487,145 — PROJECT SUMMARY/ABSTRACT Black women in the US are twice as likely to experience a preterm birth (PTB), a low birth weight (LBW) infant, or the death of a child before age one compared to white women. This profoundly disturbing racialized pattern of adverse reproductive outcomes has endured for as l…
Jessica N Cohan · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2024 · $192,061 — PROJECT SUMMARY/ABSTRACT This is a 5-year K23 career development award for Dr. Jessica Cohan, a board-certified general and colorectal surgeon and early career investigator whose research focus is optimizing person-centered surgical care for older adults. As the population ages, an increasing number…