Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Katie Whytock · ADVENTHEALTH ORLANDO · 2024 · $91,500 — PROJECT SUMMARY Type 2 Diabetes (T2D) is estimated to affect 30 million U.S. adults and skeletal muscle (SkM) insulin resistance (IR) is considered to be one of the primary aberrations. Effective insulin-stimulated SkM glucose uptake is dependent on 1) insulin-stimulated activation of terminal arter…
Yajun Ma · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $666,914 — Abstract Intervertebral disc (IVD) degeneration and related low back pain (LBP) affect up to 85% of the U.S. population over their lifetime, resulting in annual healthcare costs that exceed $100 billion. The IVD is largely avascular and consists of a central proteoglycan (PG)-rich nucleus pulposus …
Caitlin Anne Orsini · UNIVERSITY OF TEXAS AT AUSTIN · 2024 · $547,810 — Project Summary/Abstract Poor decision making and elevated risk taking may be due to chronic drug exposure and contribute to continued drug use and/or promote relapse. Animal models have been invaluable in identifying whether such elevated risk taking arises from drug-induced alterations in neural s…
Laura Marie Block · UNIVERSITY OF WISCONSIN-MADISON · 2024 · $36,850 — PROJECT SUMMARY/ABSTRACT Individuals with Alzheimer’s disease and related dementias (ADRD) experience progressive cognitive decline and behavioral and functional impairment. With disease progression, individuals with ADRD also experience heightened risk for poor outcomes which often culminate in the…
Chad Cook · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2024 · $527,351 — ABSTRACT Whereas a large body of mechanosensation knowledge exists, synergy between our current understanding of sensory mechanotransduction and Force-Based Manipulations (FBM) mechanisms across research disciplines remains severely limited. This lack of synergy between these research fields has pro…
Sherise Desiree Ferguson · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2024 · $202,500 — ABSTRACT/SUMMARY Malignant gliomas, specifically glioblastoma (GBM), are highly aggressive, incurable brain tumors. Even with maximal surgical resection, chemotherapy and radiation, tumor recurrence is absolute and median survival is approximately 14 months. Immunotherapeutic strategies have had not…
Italo Tempera · WISTAR INSTITUTE · 2024 · $457,575 — Epstein-Barr Virus (EBV) reprograms host cell gene expression and metabolism during the establishment of latency and the immortalization of B-lymphocytes. The regulatory mechanisms coordinating this reprogramming with EBV latency reflect important events in viral oncogenesis, yet remain poorly under…
SATHY VENKAT BALU-IYER · STATE UNIVERSITY OF NEW YORK AT BUFFALO · 2024 · $545,700 — Hemophilia A (HA) is a bleeding disorder caused by deficiency or dysfunction of Factor VIII (FVIII), an important blood coagulation protein. The replacement therapy using exogenous FVIII is the first line of therapy. However, a major clinical complication of this life-saving therapy is the developme…
KATHLEEN T. BRADY · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2024 · $4,506,300 — Contact PD/PI: Brady, Kathleen T. OVERALL – PROJECT SUMMARY/ABSTRACT Since 2009, the South Carolina Clinical and Translational Research Institute (SCTR) has transformed the research environment across South Carolina (SC) by creating a Learning Health System that supports high- quality clinical and t…
Sudie E. Back · TEXAS A&M UNIVERSITY · 2024 · $660,817 — PROJECT SUMMARY/ABSTRACT A substantial proportion of individuals with alcohol use disorder (AUD) also meet criteria for posttraumatic stress disorder (PTSD). The co-occurrence of AUD/PTSD is characterized by more severe symptomatology, greater functional impairment, increased suicide risk, and poore…
Hoonkyo Suh · CLEVELAND CLINIC LERNER COM-CWRU · 2024 · $494,202 — Abstract Alcohol withdrawal (AW) after chronic alcohol exposure produces a series of symptoms. Among them, generalized tonic-clonic seizures and impairments in cognition and emotion are the most severe and dangerous symptoms. Despite alcohol’s aversive effects, alcohol’s positive- reinforcing effect…
Anna Li · UNIVERSITY OF WASHINGTON · 2024 · $48,974 — PROJECT SUMMARY Understanding sensory processing in the brain has been difficult due to the complex and variable nature of neuronal activity. The primary goal of this training proposal is to determine how visual encoding is modulated by fluctuating brain-wide activity. The primary visual cortex (V1)…
PETER Kent JACKSON · STANFORD UNIVERSITY · 2024 · $506,154 — This project focuses on understanding a fundamental cellular mechanism underlying a range of important physiological signaling in humans including the control of feeding and obesity. The mechanism uses an ancient cellular signaling organelle, the primary cilium, to control responses to satiety signa…
KELLEY Marie WITHY · UNIVERSITY OF HAWAII AT MANOA · 2024 · $270,000 — Consortium for Increasing Research and Collaborative Learning Experiences The CIRCLE Program creates the infrastructure for middle and high school students from areas without adequate research experience to expand their research skills, engage in authentic research experiences, and incubate their in…
Mu A · DANA-FARBER CANCER INST · 2024 · $56,728 — PROJECT SUMMARY: Exercise benefits the body in many ways. The functions of skeletal muscle, brain, liver, bone, adipose tissue and heart all gain from various types of physical activity and training. People suffering from disabilities, morbid obesity, or age-related diseases, are usually physically …
Julia K. Bohannon · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $432,500 — PROJECT SUMMARY Nosocomial infections remain the leading cause of death in severely burned patients due to barrier loss, im- paired immunity, and high prevalence of antibiotic resistant pathogens. Immunomodulatory strategies aimed at augmenting the host response are greatly needed. Evidence suggests…
Jonathan Hale Zippin · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $606,010 — SUMMARY Melanosome pH controls pigmentation and affects skin cancer risk; however, the signaling pathways that affect this important pigment mechanism are poorly understood. The Melanocortin 1 Receptor (MC1R), through transmembrane adenylyl cyclase (tmAC)-defined cAMP signaling pathways, has an impo…
Christopher D Deppmann · UNIVERSITY OF VIRGINIA · 2024 · $450,552 — Summary: Axon degeneration occurs during development of the nervous system as well as neuropathologies including Alzheimer's, Luo Gehrig's, and Huntington's disease as well as stroke, and spinal cord injury. A common but poorly defined feature of all forms of neural degeneration is the emergence of …
Julia Marie Perhacs · DREXEL UNIVERSITY · 2024 · $48,974 — Abstract Neuronal function depends on the precise localization and release of neuromodulators, such as growth factors, in response to stimuli. Our lab recently identified an unexpected, but exciting role for ER stress sensor PERK, PKR-like ER kinase, in neuronal growth factor localization. Specific…
Silvia Miramontes Lizarraga · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $44,892 — PROJECT SUMMARY Uncovering factors influencing progression from Mild Cognitive Impairment (MCI) to Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD) represents a valuable opportunity to prevent clinical AD/ADRD and prolong functional independence of people along the AD/ADRD con…