Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
MARCO MARTINA · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $483,395 — Summary The neurobiological basis of chronic pain is poorly understood and no scientifically validated therapies exist for such condition. Yet, chronic pain has an enormous socio-economic price, estimated to reach US$ 635 billion annually in healthcare costs and lost productivity. To make things wor…
Donal S O'Leary · WAYNE STATE UNIVERSITY · 2024 · $416,326 — Gastrointestinal and cardiovascular health are intimately linked, yet the mechanism by which diet-derived lipid metabolites and the gut microbial flora impact efferent sympathetic nerve activity is largely unknown. Work from our laboratory and others’ provides increasing evidence that the enteric ne…
Gregory Alan Abel · DANA-FARBER CANCER INST · 2024 · $83,107 — SUMMARY The University of Massachusetts Boston (UMass Boston) and Dana-Farber/Harvard Cancer Center (DF/HCC) Partnership is primed for “Bridging the Divides: Innovations to Address Gaps in Cancer Disparities Research, Education, Outreach and Infrastructure.” Our goal is to pursue Partnership activit…
Aleksandar Denic · MAYO CLINIC ROCHESTER · 2024 · $351,377 — PROJECT SUMMARY/ABSTRACT The prevalence and burden of chronic kidney disease (CKD) is increasing worldwide. Patients who undergo radical or partial nephrectomy for kidney cancer resemble the general population with comorbidities, but with the difference that a majority undergo pre- and post-surgery …
Dongmei Li · UNIVERSITY OF ROCHESTER · 2024 · $565,181 — PROJECT SUMMARY The National Youth Tobacco Survey showed the prevalence of e-cigarette use among high school students has skyrocketed from 12% in 2017 to 28% in 2019 and remains high at 14.1% in 2022. While different regulatory policies (such as the FDA e-cigarette flavor enforcement and Tobacco 21)…
ANGIE GELLI · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $50,304 — PROJECT ABSTRACT Infections of the central nervous system (CNS) caused by fungi have the highest morbidity and mortality when compared to other causative agents of CNS infections. Cryptococcus neoformans (Cn), Candida albicans, Aspergillus spp., Mucor, Coccidioides spp., and Histoplasma capsulatum a…
Panupong Mahalapbutr · KHON KAEN UNIVERSITY · 2024 · $112,974 — Title: Development of a smart transformable nanotherapeutic against cancers with acquired resistance to EGFR-targeted therapies caused by MET amplification Study Section & Awarding Component Assignment Request: Fogarty International Center Project summary/Abstract: Cancer, a significant public heal…
Luksana Chaiswing · UNIVERSITY OF KENTUCKY · 2024 · $61,429 — PROJECT SUMMARY Radiation therapy (RT) is widely used to treat localized prostate cancer (PCa). However, cancer cells often develop resistance to RT through unknown mechanisms, resulting in cancer recurrence. To improve RT, there is a dire need to uncover cellular events that cause cells to become r…
Rebecca Liang Kow · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · 2024 · $623,631 — Background: Alzheimer’s disease and other neurodegenerative diseases with accumulation of pathological tau protein, termed tauopathies, are increasing in prevalence and burden to the US population. However, there are still no therapies to cure or reverse tauopathies. Despite strong evidence that pat…
Jennifer Zellers · WASHINGTON UNIVERSITY · 2024 · $126,164 — PROJECT SUMMARY. Candidate: Dr. Zellers is a physical therapist (Doctor of Physical Therapy, Columbia University) with a PhD in Biomechanics and Movement Science (University of Delaware). She is Assistant Professor in Physical Therapy and Orthopaedic Surgery at Washington University School of Medici…
Besim Ogretmen · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2024 · $384,227 — SUMMARY Non-small cell lung cancer (NSCLC) remains the deadliest cancer, and novel therapeutic strategies are needed to improve treatment outcomes of patients with this disease. FTY720 (Fingolimod/Gilenya, Novartis) is a sphingosine analog drug approved for the treatment of refractory multiple scler…
Alexander Ploss · PRINCETON UNIVERSITY · 2024 · $30,051 — Project summary Chronic hepatitis B virus (HBV) infection results in 887,000 deaths annually. The central challenge in curing HBV is eradication of the stable covalently closed circular DNA (cccDNA) form of the viral genome, which depends on elusive host factors for its generation. Using a yeast ext…
Sergey Ryzhov · MAINEHEALTH · 2024 · $581,578 — Our new preliminary data indicate that ErbB3 signaling is essential for the integration of early inflammatory response with adaptive immunosuppression, thus preventing the activation of cardiac lymphocytes and protecting the heart against secondary immune cell-mediated tissue damage. We found that E…
William Hall · MEDICAL COLLEGE OF WISCONSIN · 2024 · $589,425 — PROJECT SUMMARY Radiotherapy is a cornerstone of treatment for prostate cancer, but radiation-related genitourinary (GU) and gastrointestinal (GI) toxicities can negatively impact quality of life among survivors. Radiotherapy can damage the bladder and rectum leading to gross bleeding, inflammation…
Richard KP Benninger · UNIVERSITY OF COLORADO DENVER · 2024 · $658,293 — PROJECT SUMMARY Type 1 diabetes (T1D) results from the destruction of insulin producing β-cells upon immune infiltration and inflammation of the islets of Langerhans in the pancreas. Prior to T1D onset there is an asymptomatic phase of many years which presents a window for therapeutic intervention.…
Matthew Blake Greenblatt · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $547,424 — Project Summary Vertebrae and long bones display marked differences across a range of clinical and basic properties, such as their basic architecture, responsiveness to PTH, their rate of seeding with solid tumor metastases, or the types of developmental and degenerative diseases present. The etiolo…
Ngan F. Huang · PALO ALTO VETERANS INSTIT FOR RESEARCH · 2024 · $556,684 — ABSTRACT: Lymphedema affects approximately 200 million patients globally, and it is characterized by the accumulation of lymph fluid in soft tissues due to obstructions in the lymphatic system. In Western countries, it most commonly occurs as a direct outcome of the cancer treatment itself, most fre…
Bruna Corradetti · BAYLOR COLLEGE OF MEDICINE · 2024 · $562,740 — ABSTRACT Neural tube defects (NTDs), including spina bifida (SB), have a devastating impact on the health and development of infants and children, with economic, social, and physical demands or hardships placed on caregivers. SB affects approximately 2,500 live births per year in the United States, …
Anne E Carlson · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $441,505 — Zinc is the most abundant trace metal in the body, and the highest zinc concentrations are found in semen. Human semen is enriched with 1-3 mM zinc, a 100-fold higher concentration than the zinc contents of other parts of the body. Moreover, low seminal zinc has been correlated with male infertility…
Denise M Monack · STANFORD UNIVERSITY · 2024 · $761,850 — Project Summary Typhoidal Salmonella serovars, including Salmonella enterica serovars Typhi (STy) and Paratyphi A (SPTyA), are the culprits behind devastating human-exclusive infections known as enteric fever, causing immense global morbidity and mortality. These pathogenic microbes adeptly outmaneu…