Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
SARAH Finocchario KESSLER · UNIVERSITY OF KANSAS MEDICAL CENTER · 2024 · $149,420 — Abstract Despite progress in providing comprehensive prevention of mother-to-child transmission of HIV (PMTCT) services, significant gaps in the timely uptake and provision of guideline-adherent services and maternal retention in care remain. Such gaps create missed opportunities for preventing moth…
Seth Rakoff-Nahoum · BOSTON CHILDREN'S HOSPITAL · 2024 · $663,173 — SUMMARY. From initially cataloging the microbiome, we can now causally link specific strains and metabolites of the microbiome with protective and pathogenic roles in a broad range of human disease. We are now faced with the challenge of shaping beneficial microbiomes, such as at the strain-level, a…
Ruslan Rafikov · INDIANA UNIVERSITY INDIANAPOLIS · 2024 · $742,328 — Hemolysis is one of the critical pathogenic mechanisms of pulmonary hypertension (PH), predisposing individuals with hemolytic conditions to PH. Notably, 10-30% of sickle cell disease patients and up to 80% of thalassemia patients develop PH, starkly contrasting to a mere 0.001% prevalence in the ge…
BRIAN O BACHMANN · VANDERBILT UNIVERSITY · 2024 · $661,374 — PROJECT SUMMARY Natural product therapeutics remain critically important in the treatment of cancer, with most patients diagnosed with cancer receiving natural product-based chemotherapy, such as microtubule disrupting agents and DNA intercalators. Select chemotherapeutic small molecules, the majori…
Pranav Soman · SYRACUSE UNIVERSITY · 2024 · $322,408 — Summary Osteocytes are the most numerous cell in bone tissue, which act as mechanosensors and coordinate adaptive bone remodeling. Current model systems have been unable to unify the mechanisms by which osteocytes to sense mechanical stimuli, transmit signals across an extensive 3D network, and how …
Daniel Lacorazza · BAYLOR COLLEGE OF MEDICINE · 2024 · $426,306 — Project Summary Chronic myeloid leukemia (CML) is an aggressive hematological malignancy caused by the oncoprotein BCRABL1. Although tyrosine kinase inhibitors (TKIs) can help CML patients achieve molecular remission, they cannot be fully cured because the leukemic stem cells (LSCs) are still presen…
Brady J Maher · LIEBER INSTITUTE, INC. · 2024 · $908,174 — PROJECT SUMMARY: Schizophrenia (SCZ) is a complex polygenic disorder, encompassing a spectrum of positive and negative clinical symptoms and cognitive deficits that vary considerably between individuals. Unfortunately, progress in understanding the etiology and pathophysiology is hindered by the lac…
Paul J Brindley · GEORGE WASHINGTON UNIVERSITY · 2024 · $382,600 — Project Summary Liver fluke infection with Opisthorchis viverrini remains problematic in East Asia and is endemic in Thailand and Laos, where ~10 million people are infected. The public health implications of this situation are substantial since there is no stronger link between a human malignancy a…
Aryeh Warmflash · RICE UNIVERSITY · 2024 · $329,834 — Project Summary During embryonic development, extracellular proteins, known as morphogens, play a key role in conveying positional information and establishing cell fates. While theoretical descriptions have posited plausible models for how morphogens might shape embryonic development, until recentl…
Gloria Choi · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2024 · $473,814 — ABSTRACT Sickness behaviors represent a range of behavioral changes that manifest in response to infection or inflammation. These changes include reduced physical activity, diminished social interaction, and altered feeding behavior. It is suggested that these behavioral shifts are integral to the …
Sara Malone · WASHINGTON UNIVERSITY · 2024 · $398,207 — PROJECT SUMMARY/ABSTRACT Children with cancer in low-resource settings face a survival rate of only 20%. Clinical deterioration, defined as the worsening of patient status that requires clinical teams to recognize and respond in a coordinated fashion, remain a major cause of childhood cancer mortali…
Zuoming Sun · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · 2024 · $753,164 — Retinoid-related orphan receptor gamma t (RORyt) is a transcription factor that regulates the differentiation of Th17 cells in the peripheral immune system and the development of thymocytes in the central immune system. As pathogenic Th17 cells are responsible for tissue damages associated with many…
Michael D Sheets · UNIVERSITY OF WISCONSIN-MADISON · 2024 · $575,095 — Abstract: Over the course of an animal’s lifetime, cell-fate decisions are continually being made that allow for normal development and growth as well as the health of the adult organism. Cell- fate decisions require precisely controlled temporal and spatial expression of particular proteins. In ear…
Samithamby Jeyaseelan · LOUISIANA STATE UNIV A&M COL BATON ROUGE · 2024 · $715,216 — SUMMARY Pneumonia-derived sepsis remains a persistent and pervasive public health problem. Pneumonia and sepsis are the major causes of Acute Respiratory Distress Syndrome (ARDS). No clinical studies other than the ARDSnet ventilator trial provided better outcomes for ALI/ARDS. Therefore, an improve…
Romulo Hurtado · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $577,420 — Abstract Impaired urinary outflow that causes damage to the urinary tract and kidney is a major cause of kidney disease, which affects 15% of the population and costs $100B annually. For instance, hydronephrosis, a pressure mediated dilation and damage of the renal tissues, is the leading cause of p…
Deblina Sarkar · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2024 · $641,779 — Cardiovascular disease is the leading cause of morbidity and mortality worldwide and is responsible for 20% of deaths in the United States alone. Among both disabling and fatal events, cardiac arrhythmias play a central role. In this context, electrophysiological studies of cardiac models of arrhyth…
Hannah M Fisher · DUKE UNIVERSITY · 2024 · $173,997 — Patients with life-threatening hematologic cancer experience insomnia and fatigue, distress, and pain symptoms that worsen insomnia during and following hospitalization for high-dose chemotherapy. Despite an urgent need, there are limited symptom management protocols that comprehensively target the …
Isabel Bleimeister · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $48,974 — Project Summary/Abstract Pain is a debilitating condition that severely impacts quality of life. Despite a growing need for new treatments, an incomplete understanding of the neural circuitry underlying pain has limited the development of novel pain therapeutics. Spinal projection neurons in the sup…
Lachelle Dawn Weeks · DANA-FARBER CANCER INST · 2024 · $165,080 — Project Summary Clonal hematopoiesis (CH) is the pre-malignant expansion of a population of blood cells derived from a single hematopoietic stem cell and is often caused by somatic mutations in leukemia driver genes. CH has been associated with significant clinical outcomes including hematologic can…
Jinming Gao · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $984,000 — Abstract Host defense responses by the mammalian immune system can be very potent but require exquisite spatio-temporal coordination. This coordination is essential to match the immune activity to the specific threat, to monitor and regulate the immune response, minimize damage to normal tissues, a…