Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
HUA HUANG · NATIONAL JEWISH HEALTH · 2024 · $251,972 — PROJECT SUMMARY: Interleukin-13 (IL-13) is a key effector cytokine in causing allergic inflammation and in immunity against certain parasitic infections. The Il13 gene, like many cytokine and chemokine genes, is transcribed at low levels in resting effector cells and is dramatically upregulated in r…
Mandar Deepak Muzumdar · YALE UNIVERSITY · 2024 · $62,848 — PROJECT SUMMARY/ABSTRACT Despite significant advances in cancer care, pancreatic ductal adenocarcinoma (PDAC) remains the third leading cause of cancer death in the United States with a 5-year survival rate of ~10%. Obesity and high fat diet (HFD) consumption increase PDAC risk in human cohorts and …
Jie Jiang · EMORY UNIVERSITY · 2024 · $75,699 — PROJECT SUMMARY/ABSTRACT Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease caused by the loss of upper and lower motor neurons, leading to progressive muscle weakness and paralysis. Many altered molecular and cellular pathways have been implicated in disease pathogenesis…
Cory Dungan · BAYLOR UNIVERSITY · 2024 · $215,600 — Project Summary. Skeletal muscle mass and function are key determinants of an individual’s healthspan and are tightly correlated with both physical and metabolic health. In cancer survivors, the loss of muscle mass that occurs following cancer, termed cancer cachexia, is a major contributor to morta…
Andrea Velasquez · UNIVERSITY OF COLORADO DENVER · 2024 · $156,000 — Project Title Long-term effects of universal health insurance in developing countries: Evidence from Mexico Project Summary/Abstract (30 lines of text) The implementation of government programs to increase access to health insurance has rapidly increased in developing countries in the last three dec…
Caleb Andrew Lareau · SLOAN-KETTERING INST CAN RESEARCH · 2024 · $1,061,833 — PROJECT SUMMARY At the turn of the millennium, the cost of sequencing one megabase of DNA exceeded 10 million dollars. Today, decoding that same megabase costs less than a penny. This dramatic reduction in the cost of sequencing has catalyzed a genomics revolution and resulted in petabases (million…
Scott R Floyd · DUKE UNIVERSITY · 2024 · $413,971 — ABSTRACT: Radiation therapy is a necessary component of current treatment for many brain tumors. Radiation therapy leverages a therapeutic ratio in which tumor cells suffer radiation damage and die, while normal brain cells repair radiation damage and are less negatively affected. Improvements in th…
MUHAMMAD FAHEEM AMITH · UNIVERSITY OF TEXAS MED BR GALVESTON · 2024 · $223,697 — Project Abstract The incidence of type 2 diabetes mellitus (T2DM) is staggeringly high in the United States, and it is expected to exponentially increase in the next few decades. Regulating health behavior that leads to T2DM is a key factor that can slow the down prevalence of T2DM and decrease any …
Kathiresan Selvam · WASHINGTON STATE UNIVERSITY · 2024 · $244,750 — ABSTRACT Transcription coupled-nucleotide excision repair (TC-NER) plays a critical role in the maintenance of genome stability by removing DNA lesions that would otherwise block RNA polymerase II (Pol II) transcription. The importance of TC-NER to human health is highlighted in Cockayne syndrome (C…
Benjamin P. Weaver · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $451,000 — Project Summary Compromised tissue integrity is a major cause of debility during aging. Emerging findings suggest critical functions of lysosomes promoting tissue integrity. Our unpublished findings indicate key roles for C. elegans PMK-1, a conserved p38 MAPK member, in promoting lysosome formation…
Ketan Shrestha · UNIVERSITY OF KENTUCKY · 2024 · $154,000 — TITLE: Role of Long non-coding RNAs in the Ovulatory Process. ABSTRACT Women’s reproductive health plays a pivotal role in regulating overall well-being. Unfortunately, about 12% of reproductive-age women experience infertility. One of the most common causes of infertility is anovulation or oligo-o…
Laura Marie Sinko · TEMPLE UNIV OF THE COMMONWEALTH · 2024 · $250,709 — Project Summary Research has documented that gender-based violence (GBV; e.g. intimate partner violence, sexual assault, child abuse, hate-motivated violence) disproportionately impacts sexual and gender minority (SGM) populations, with unaddressed victimization experiences representing a key driver…
Lori L O'Brien · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $421,067 — Abstract In utero exposures to insults such as pregestational diabetes can have significant repercussions for proper growth and development. Exposure to the diabetic milieu can lead to diabetic embryopathy, a disruption in normal cellular programs during critical stages of development which leads t…
Yan-Ting Chen · SLOAN-KETTERING INST CAN RESEARCH · 2024 · $50,474 — PROJECT SUMMARY/ ABSTRACT Immune checkpoint blockade (ICB), aimed at reinvigorating immune cells such as T-cells, has exhibited clinical success in a subset of patients yet fails to be applicable to many tumor subtypes. These unresponsive subtypes upregulate gene signatures associated with amino aci…
Viral Oza · UNIVERSITY OF KENTUCKY · 2024 · $35,602 — PROJECT SUMMARY Diffuse midline gliomas with H3K27M alteration (DMG-H3K27M) are the leading cause of pediatric brain tumor-associated deaths. All DMG-H3K27M becomes resistant to radiation, the standard of care, and most children succumb to their disease within two years of diagnosis. New treatment …
Francesca Demichelis · CEDARS-SINAI MEDICAL CENTER · 2024 · $649,486 — ABSTRACT - The focus of this proposal is on lethal, metastatic prostate cancer (PC). The aim of this study is to develop an innovative, minimally invasive, liquid biopsy assay that can be used to identify molecular subtypes of lethal prostate cancer PC in patients with a biologically aggressive dise…
Kayvan R Keshari · SLOAN-KETTERING INST CAN RESEARCH · 2024 · $35,552 — PROJECT SUMMARY/ABSTRACT (unchanged from initial application) Acute myeloid leukemia (AML) is a genetically complex and heterogeneous set of diseases characterized by a diverse set of mutations. Although many patients initially respond to treatment, many end up relapsing. Over the last decade, an ap…
Ream Al-Hasani · WASHINGTON UNIVERSITY · 2024 · $497,550 — Abstract The overall goal of this research is to better understand how endogenous opioids control the analgesic properties of the central noradrenergic system. Endogenous opioid systems provide powerful inhibition of locus coeruleus noradrenergic neurons and acute activation of mu opioid receptors i…
SHU CHIEN · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $840,873 — Project Summary Shear stresses resulting from distinct blood flow patterns impact endothelial cell (EC) functions. ECs under atheroprone flow exhibit increased proliferation, inflammation, and glycolysis, compared to those under atheroprotective flow. Our recent studies have uncovered a novel role o…
Dylan A. McCreedy · TEXAS A&M UNIVERSITY · 2024 · $46,078 — Project Summary/Abstract Inflammation plays a critical role in secondary tissue damage after spinal cord injury (SCI), however, there is no widely accepted therapeutic for mitigating destructive inflammatory events in the injured spinal cord. L-selectin is an adhesion and signaling receptor on immun…