Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Nicholas Jendzjowsky · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · 2024 · $332,000 — Project Summary Asthma and asthmatic symptoms continue to persist and are a growing health burden demonstrating the need to understand how the main asthmatic effector molecule, immunoglobulin (Ig) E (IgE), is produced. Asthmatic pathology occurs by IgE being produced in response to what are typicall…
Noa Ofen · UNIVERSITY OF TEXAS DALLAS · 2024 · $605,545 — PROJECT SUMMARY/ABSTRACT The human ability to retrieve information from past experiences is essential for everyday living, shows robust improvement across childhood, and is impaired in many psychiatric and neurological disorders. Yet we know little about the neurophysiological mechanisms subserving …
Arjun Vijay Masurkar · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $2,044,038 — PROJECT SUMMARY/ABSTRACT Anxiety is a highly prevalent symptom in the early stages of Alzheimer disease (AD), with correlation to AD biomarkers and association with faster decline. As such, understanding the mechanism of anxiety in AD is critical to understanding its impact on outcomes and to develo…
Chao Zhao · UNIVERSITY OF ALABAMA IN TUSCALOOSA · 2024 · $364,336 — PROJECT SUMMARY Local anesthesia is a clinical option for the treatment of post-operative pain that may typically persist for 5-7 days and chronic pain phenotype that lasts longer than 12 weeks. Conventional amino-amide and amino-ester local anesthetics are effective, but the duration of a typical n…
Joanna E Burdette · UNIVERSITY OF ILLINOIS AT CHICAGO · 2024 · $622,570 — Ovarian cancer is the most lethal cancer of the female reproductive system, with over 21,000 new ovarian cancer diagnoses and 14,000 deaths annually in the US. The total lifetime number of ovulations is a key risk factor for developing ovarian cancer. Factors that repress ovulation reduce the risk o…
Patricia G. Buzelli · DUKE UNIVERSITY · 2024 · $48,974 — ABSTRACT Latinx children in the United States (US) are more than 50% more likely to die of their cancer diagnosis in comparison to non-Latinx White children due to systemic inequities which arise from adverse social determinants of health (SDOH). Latinx families in the US face several adverse SDOH i…
Jean Kyou Lim · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $84,500 — PROJECT SUMMARY: CCR5 is a chemokine receptor that holds significant importance in public health due to the following factors: 1) CCR5 is the primary co-receptor for HIV infection; 2) approximately 1% of individuals with European ancestry worldwide possess a natural deficiency in CCR5; 3) an FDA-app…
Victoria Celine Rosado · HARVARD MEDICAL SCHOOL · 2024 · $43,456 — Project Summary / Abstract This application proposes to define how B cell receptor binding site (BCRbs) copy number at the plasma membrane surface is an actively regulated parameter that is developmentally tuned to optimize antigen recognition and support affinity-driven antibody selection with B ce…
Laura Korthauer · RHODE ISLAND HOSPITAL · 2024 · $75,600 — PROJECT ABSTRACT There is a strong public health need to detect Alzheimer’s disease (AD) in its earliest stages and predict who is most vulnerable to clinical progression. The goal of this K23 proposal is to provide the candidate with the experience, knowledge, and technical expertise to independent…
Kylie Jacobs · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2024 · $76,756 — PROJECT SUMMARY Amino acids are an intrinsic part of protein biosynthesis, nucleotide production, and provide sources of carbon and nitrogen for the cell. The cell keeps amino acid (AA) levels balanced by increasing AA transporters on the cell surface, catabolizing AAs to form essential metabolites,…
Lucy Luo · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $52,897 — PROJECT SUMMARY: Chronic lung allograft dysfunction (CLAD) is the primary driver of morbidity and mortality in lung transplant recipients. Currently there is a need to identify clinical and molecular biomarkers of CLAD, where the latter has the potential to inform targetable pathways for interventio…
Graham Scott Erwin · BAYLOR COLLEGE OF MEDICINE · 2024 · $249,000 — Expansion of a single repetitive DNA sequence, termed a tandem repeat (TR), causes more than 30 rare but devastating diseases. Despite their importance to monogenic disease, the frequency and function of repeat expansions are unknown in complex human diseases. A failure to catalog and understand the…
Khadija Shafiq · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $48,974 — PROJECT SUMMARY Macrocyclic peptides are effective scaffolds for cancer drug discovery because they can combine the metabolic stability and target specificity of biologics with oral bioavailability and membrane permeability of small molecules. The bicyclic octapeptide moroidin is a promising lead st…
Sara Marie Gannon · DUKE UNIVERSITY · 2024 · $41,901 — PROJECT SUMMARY A fundamental feature of perception is the ability to recognize objects or object features despite changes in presentation, such as size, position, or context. Elucidating the mechanisms by which cortical populations and circuits build representations that are invariant to these mani…
Maxwell T Frankfurter · UNIVERSITY OF PENNSYLVANIA · 2024 · $53,974 — Project Summary The placenta is a transient, vascular organ necessary for in utero gas, nutrient, waste exchange in the majority of mammals. Placental dysfunction may lead to hypertensive disorders of pregnancy, fetal growth restriction, or intrauterine fetal demise in humans. In mice and humans, co…
Lauren Elizabeth Parker · DUKE UNIVERSITY · 2024 · $53,974 — Abstract Heart failure is a leading cause of death worldwide and there is a critical, unmet need for non-surgical therapies. A key barrier to developing curative therapy is that the human heart, unlike that of zebrafish, axolotls, and some neonatal mammals, lacks the ability to recover after acute o…
Steven W Barger · UNIV OF ARKANSAS FOR MED SCIS · 2024 · $49,447 — SUMMARY Aging is the most powerful risk factor for Alzheimer’s disease (AD), and it contributes to the odds of type-2 diabetes mellitus (T2D) as well. Aging is also associated with a decline in the brain’s use of glucose, its most important fuel. Astrocytes play a key role in shuttling glucose from …
Meghan Bridgid Moran · JOHNS HOPKINS UNIVERSITY · 2024 · $2,490,060 — PROJECT SUMMARY Effective communication strategies are urgently needed to convey the relative risks of tobacco products accurately among adults who currently use combustible tobacco while minimizing such appeal among youth populations. There is a significant gap in research on the impacts of communi…
Riley Jordan Felicicchia · SAN DIEGO STATE UNIVERSITY · 2024 · $39,125 — Project Summary/Abstract Prenatal alcohol exposure (PAE) can cause a wide range of neurocognitive, behavioral, and functional impairments that persist throughout the lifespan. The collective impairments of PAE are known as fetal alcohol spectrum disorders (FASD). FASD is an umbrella term which encom…
Alexis Marie Johnson · UNIVERSITY OF VIRGINIA · 2024 · $38,001 — PROJECT ABSTRACT/SUMMARY: Tauopathies are a broad, prevalent, and lethal class of neurodegenerative disorders that affect up to 7 million Americans. There is a tremendous need for improved therapeutic strategies to treat the conditions that fall under this category, namely Alzheimer's disease (AD) a…