Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Carl Nist-Lund · HARVARD MEDICAL SCHOOL · 2024 · $36,919 — Abstract: Novel inner ear organoid models for studying hair cells in normal development and in the deaf- blindness disease Usher Syndrome Type 1F The fundamental human sense of balance, which comprises both movement through the world and one’s body position in space, begins with specialized biologic…
TONY R MERRIMAN · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2024 · $317,476 — Gout is the most common inflammatory arthritis, but beyond the well described role of the NLRP3 inflammasome, the molecular genetic causes of gout flares is least well known among the arthropathies. Published and preliminary results from our group have implicated genes associated with inflammation i…
Rachel E. Lew · OHIO STATE UNIVERSITY · 2024 · $37,594 — TITLE Biochemical properties and implications of NRAS mutant-specific BRAF interactions in melanoma ABSTRACT Extracellular growth factors promote cellular proliferation, motility, and survival through a complex network of signal transduction pathways. Thus, mutations in these pathways can cause inap…
Humberto Monsivais · PURDUE UNIVERSITY · 2024 · $27,407 — Abstract: The welding industry in the US exposes over 600,000 workers to toxic welding fumes, including the neurotoxic metal manganese (Mn), which can cause manganism, a condition with psychological, cognitive, and motor deficits similar to Parkinson's disease. While effects of inhalation exposure t…
Kanako Matsumura · UNIVERSITY OF TEXAS AT AUSTIN · 2024 · $45,771 — PROJECT ABSTRACT 40% of patients who are diagnosed with cocaine use disorder are considered to have a severe cocaine use disorder meeting six or more criteria from the DSM-5. The lack of effective medication for cocaine use disorder demonstrates an urgent need to better understand the effect of coca…
Jennifer L Garrison · BUCK INSTITUTE FOR RESEARCH ON AGING · 2024 · $49,000 — PROJECT SUMMARY We are requesting funds to support the Reproductive Aging Conference annually for 3 years, 2023 - 2025. The 2023 meeting will be held at the Omni Rancho Las Palmas Resort (Palm Springs, California, USA) on May 2 - 5, 2023. This will be the second meeting following the Inaugural confe…
Apollo Stacy · CLEVELAND CLINIC LERNER COM-CWRU · 2024 · $249,000 — Project Summary/Abstract Research: Periodontitis (gum disease) is one of the most common inflammatory diseases worldwide, affecting nearly 50% of adults (65 million people) in the US alone. Untreated, it can destroy the tissues that support the teeth, eventually resulting in tooth loss. The cause o…
Michal Toborek · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2024 · $471,362 — ABSTRACT HIV-1-infected individuals are at a higher risk for non-AIDS related co-morbidities, including cerebrovascular and neurological diseases. These pathologies may be driven, at least in part, by low levels of viral replication that persist in HIV-infected brains, which can lead to immune activ…
Elliot Todd Berkman · UNIVERSITY OF OREGON · 2024 · $562,286 — 7. Project Summary/Abstract Lung cancer is the leading major cause of preventable death in the United States, and cigarette smoking is a contributor to lung cancer in 80%–90% of cases. Though adult cigarette smoking rates have declined substantially during the past 50 years, they remain as high as 3…
BENEDICT C ALBENSI · NOVA SOUTHEASTERN UNIVERSITY · 2024 · $154,000 — ABSTRACT Metabolic disorders (i.e. obesity, prediabetes or type 2 diabetes), often resulting from poor diet, is a significant risk factor for Alzheimer’s disease (AD). Several common neurodegenerative mechanisms in these two conditions have been identified, including oxidative stress, mitochondrial …
Lee Erik Korshoj · UNIVERSITY OF NEBRASKA MEDICAL CENTER · 2024 · $22,724 — PROJECT SUMMARY A craniotomy allows neurosurgeons to access the brain for procedures that include tumor resection, localization and resection of epileptogenic foci, and aneurysm clipping via the removal and intraoperative replacement of a skull fragment (bone flap). Infection following craniotomy oc…
Edward Burgard · DIGNIFY THERAPEUTICS, LLC · 2024 · $1,473,895 — ABSTRACT Spinal cord injury, multiple sclerosis, Parkinson’s disease, spina bifida, and stroke, as well as complications due to aging and diabetes, can produce a loss of voluntary control over bowel and bladder function resulting in both fecal and urinary incontinence as well as retention in the sam…
Andrew S Mendiola · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $241,530 — PROJECT SUMMARY / ABSTRACT Oxidative stress is a central part of innate immune-induced neurodegeneration in neurological disorders including multiple sclerosis (MS). However, the molecular mechanisms regulating oxidative stress gene circuits to promote neurotoxic immune responses remain poorly chara…
Matthias Stangl · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · 2024 · $241,421 — PROJECT SUMMARY/ABSTRACT Spatial navigation is a fundamental human behavior, and deficits in navigational functions are among the hallmark symptoms of severe neurological disorders such as Alzheimer’s disease. Understanding how the human brain processes and encodes spatial information is thus of cri…
SMITA S PATEL · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · 2024 · $828,047 — Project Summary The overarching goal of our research is to understand the mechanisms of helicases and polymerases in processes such as viral RNA recognition, DNA transcription, and replication. The unifying approach is the quantitative characterization of the enzymatic reactions using rigorous bioch…
Barna Dudok · BAYLOR COLLEGE OF MEDICINE · 2024 · $241,531 — Epilepsy affects 50 million people worldwide. In 40% of patients with temporal lobe epilepsy (TLE), antiepileptic drugs fail to prevent seizures, increasing the risk of injury, cognitive decline, and death. The impairment of inhibition by GABAergic interneurons (IN) is a key pathomechanism of epilep…
Susan D. Michaelis · JOHNS HOPKINS UNIVERSITY · 2024 · $591,558 — PROJECT SUMMARY This project aims to define the role of farnesylated prelamin A in premature and physiological aging. Genetic mutations leading to defective processing of prelamin A, the precursor for the nuclear scaffold protein lamin A, result in persistence of its farnesyl modification and cause …
Maryam Naghibolhosseini · MICHIGAN STATE UNIVERSITY · 2024 · $189,391 — Project Summary/Abstract This proposal aims to develop Bayesian subject-specific computational models of voice production in vocally normal individuals and patients with structural voice disorders. Voice production is a complex biophysical process, consisting of vocal fold biomechanics and sub-glot…
JASON S DEBLEY · UNIVERSITY OF WASHINGTON · 2024 · $1,615,395 — Summary Lower respiratory tract viral infections serve as the dominant trigger for the onset and progression of asthma. Although asthma management has shifted towards targeting airway inflammation at all levels of the disease, primarily with inhaled corticosteroids (ICS) and biologic therapies targe…
Brian A Coffman · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $737,239 — Schizophrenia (Sz) is a debilitating major mental illness with life-long disability that disproportionately burdens the healthcare system and society. Despite decades of research, the underlying mechanisms of pathophysiology in Sz are unknown. Attempts for determining brain abnormalities in Sz have …