Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Rasika M Harshey · UNIVERSITY OF TEXAS AT AUSTIN · 2024 · $560,773 — Virus-host interactions and microbial ecology This proposal encompasses two very different aspects of microbiology, both at cellular and group levels. (1) Probing E. coli genome organization and chromosome dynamics using phage Mu transposition as our tool. Mu transposition is unique not only in its …
Kelly P. Cosgrove · YALE UNIVERSITY · 2024 · $320,498 — The goal of the Translational Alcohol Research Program (TARP) is to facilitate the ability of emerging post-doctoral researchers to bridge the gap in the application of knowledge gained from basic to clinical and social behavioral science research in alcohol use disorders (AUD) and alcohol- related …
Ronald Kent June · MONTANA STATE UNIVERSITY - BOZEMAN · 2024 · $333,738 — All cells are subject to and respond to mechanical forces like compression. However the molecular mechanisms linking the mechanics to biological responses are not fully understood. The cells of our model system, the chondrocytes of cartilage, undergo compression in vivo, and these cells can transduc…
CUN-YU WANG · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $389,587 — The long-term objectives of this application are to understand how super-enhancers (SEs) control the invasive growth and metastasis of head and neck squamous cell carcinoma (HNSCC) and to develop novel therapeutics for HNSCC. HNSCC is highly invasive and resistant to cancer therapy and frequently me…
STEVEN A WEINMAN · UNIVERSITY OF KANSAS MEDICAL CENTER · 2024 · $602,586 — PROJECT SUMMARY Alcohol-associated liver disease (ALD) is a major world-wide health problem that accounts for approximately 40,000 deaths per year in the US. A major cause of death in ALD is the onset of an acute liver failure event called alcohol-associated hepatitis (AH). The mechanisms that cause…
SANFORD D. MARKOWITZ · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $39,393 — Project Summary. Prostaglandin E2 (PGE2) regulates tissue growth and repair in multiple organs. A conserved mechanism of synthesis and degradation modulates PGE2 levels in response to trauma, inflammation and disease. In particular, the enzyme 15-prostaglandin dehydrogenase (15-PGDH) is the main PGE…
Jason C. Wester · OHIO STATE UNIVERSITY · 2024 · $368,747 — PROJECT SUMMARY/ABSTRACT During brain development, neurons must properly differentiate into distinct subtypes to assemble healthy circuits. Thus, disruption of this process can impact neural architecture and wiring, and contribute to disorders such as autism, schizophrenia, and epilepsy. The hippoca…
JUDITH B GRINSPAN · UNIVERSITY OF PENNSYLVANIA · 2024 · $870,237 — Despite effective viral control by Antiretroviral therapy (ART), HIV associated neurocognitive disorder (HAND)persists in 30-50% of people with HIV (PWH). The pathology of HAND includes white matter (WM) changes such as decreased myelin sheath thickness, myelin lesions, and abnormal myelin protein e…
James William Checco · UNIVERSITY OF NEBRASKA LINCOLN · 2024 · $367,118 — PROJECT SUMMARY/ABSTRACT Targeting neuropeptide and peptide hormone signaling is a promising strategy to treat a wide range of human diseases, including neurodegenerative diseases, diabetes, osteoporosis, and cancer. A rigorous molecular-level understanding of how specific peptide molecules signal …
Alan Joseph Emanuel · EMORY UNIVERSITY · 2024 · $241,530 — Career Plan and Environment of Career Development: Dr. Emanuel is a joint postdoctoral fellow in the laboratories of Drs. David Ginty and Chris Harvey who is dedicated to a career as an academic researcher. Drs. Emanuel, Ginty, and Harvey have developed a 12-point career development plan that will e…
Frederic Tremaine Billings · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $432,500 — Project Summary/Abstract More than 20% of patients undergoing major surgery experience acute kidney, brain, and heart injury, and these perioperative complications lead to persistent organ dysfunction, long-term morbidity, and death. My research program is investigating and manipulating mechanisms …
Courtney Filippi · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $245,363 — PROJECT SUMMARY/ABSTRACT Behavioral inhibition (BI), a temperament characterized by fear of novelty, is the best behavioral marker of which children are at risk for anxiety. However, the neurodevelopmental mechanisms that underly the pathway from BI to anxiety remain elusive. Extensive evidence lin…
MOLLY F PRZEWORSKI · COLUMBIA UNIV NEW YORK MORNINGSIDE · 2024 · $148,553 — PROJECT SUMMARY Mutation and meiotic recombination are the sources of all genetic variation, the fuel of evolution, and the ultimate cause of heritable diseases and of many cancers. Consequently, their rates and properties are of fundamental interest, as well as key parameters in almost any populati…
Jerreed Dean Ivanich · UNIVERSITY OF COLORADO DENVER · 2024 · $619,362 — PROJECT SUMMARY American Indian (AI) youth demonstrate early substance use initiation and subsequently high substance misuse rates. One factor contributing to this is the relative lack of prevention strategies that leverage contextual and cultural strengths to optimize effectiveness and sustainabili…
Daphne Christina Avgousti · FRED HUTCHINSON CANCER CENTER · 2024 · $484,000 — PROJECT SUMMARY The eukaryotic genome is compacted in a basic repeating structure called chromatin, the anomalous regulation of which is characteristic of many diseases. In recent years, the technologies to study chromatin have leapt forward, allowing us to investigate chromosome interactions in thr…
Norma Frizzell · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · 2024 · $361,325 — ABSTRACT Mitochondrial diseases are respiratory chain disorders in which the mitochondria are no longer operating efficiently to produce ATP, usually due to a problem with one or more components of the oxidative phosphorylation machinery. Mitochondrial diseases manifesting as encephalopathies occur …
Anne E Carlson · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $477,370 — PROJECT SUMMARY TMEM16A is a calcium-activated chloride channel that is required for numerous physiologic processes, including regulation of neuronal and cardiac excitability, uterine contractility, regulation of electrolyte balance, and sensory transduction. Their importance is supported by the emb…
Kimberly F Doheny · JOHNS HOPKINS UNIVERSITY · 2024 · $604,295 — PROJECT SUMMARY The Johns Hopkins Predoctoral Training Program in Human Genetics (HG) has long been a nationally preeminent training environment for human genetic research. It has grown steadily since its inception (1980) in parallel to the explosive growth of genetics and genomics, and their applic…
Karen J Guillemin · UNIVERSITY OF OREGON · 2024 · $416,855 — SUMMARY/ABSTRACT This application requests funding to support eight predoctoral students in the University of Oregon’s Genetics Training Program (GTP). The students will train with one of 27 faculty mentors whose expertise collectively span the subdisciplines of molecular, developmental, and evoluti…
DAVID Tobin FELSON · BOSTON UNIVERSITY MEDICAL CAMPUS · 2024 · $10,060,442 — OVERALL ABSTRACT The Multicenter Osteoarthritis (MOST) Study has been a major source of new knowledge about the course of OA and factors that affect it, having published over 180 articles ranging from studies of pain and pain sensitization, to investigations of biomechanics, to inquiries into struct…